Alternate cadmium exposure differentially affects the content of gamma-aminobutyric acid (GABA) and taurine within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats

2001 ◽  
Vol 75 (3) ◽  
pp. 127-133 ◽  
Author(s):  
Esquifino A. ◽  
Seara R. ◽  
Fernández-Rey E. ◽  
Lafuente A.
Keyword(s):  
Prefrontal Cortex ◽  
Median Eminence ◽  
Cadmium Exposure ◽  
Aminobutyric Acid ◽  
Male Rats ◽  
Gamma Aminobutyric Acid

Gamma-Aminobutyric Acid and Dysregulation of TSH Secretion in Uremic Male Rats

Nephron ◽  
1987 ◽  
Vol 46 (3) ◽  
pp. 301-304 ◽  
Author(s):  
Alan N. Elias ◽  
Nosratola D. Vaziri ◽  
M.R. Pandian ◽  
Krish Iyer ◽  
Mohammad A. Ansari
Keyword(s):  
Aminobutyric Acid ◽  
Male Rats ◽  
Gamma Aminobutyric Acid ◽  
Tsh Secretion

EFFECT OF VARIOUS PUTATIVE NEUROTRANSMITTERS ON THE SECRETION OF CORTICOTROPHIN-RELEASING HORMONE FROM THE RAT HYPOTHALAMUS IN VITRO – A MODEL OF THE NEUROTRANSMITTERS INVOLVED

1976 ◽  
Vol 69 (1) ◽  
pp. 1-10 ◽  
Author(s):  
M. T. JONES ◽  
E. W. HILLHOUSE ◽  
JANET BURDEN
Keyword(s):  
Median Eminence ◽  
Incubation Medium ◽  
Direct Action ◽  
Aminobutyric Acid ◽  
Male Rats ◽  
Releasing Hormone ◽  
Inhibitory Neurotransmitters ◽  
Basal Release ◽  
Dose Dependent

SUMMARY The effect of incubating the hypothalamus of adult male rats with various neurotransmitters upon the release of corticotrophin-releasing hormone (CRH) was studied. The CRH activity in the incubation medium was assayed in 48 h median eminence-lesioned rats and the corticosteroidogenesis of excised adrenals in vitro was used as the end-point. 5-Hydroxytryptamine (100 pg/ml–10 ng/ml) caused a dose-dependent release of CRH which was antagonized by methysergide (30–100 ng/ml). The response to 5-hydroxytryptamine was also inhibited by hexamethonium and atropine which indicated that it was acting through a cholinergic interneurone. Melatonin (10 ng) did not alter the basal release of CRH but inhibited the action of both 5-hydroxytryptamine (10 ng) and acetylcholine (3 pg). Thus it appears that both 5-hydroxytryptamine and melatonin play a role in the control of CRH release. Noradrenaline blocked the release of CRH induced by both acetylcholine and 5-hydroxytryptamine and presumably this inhibition was caused by direct action on the CRH neurone. γ-Aminobutyric acid (GABA) also inhibited the release of CRH and may also be involved in the regulation of CRH secretion. The inhibitory neurotransmitters, noradrenaline, GABA and melatonin, act via independent receptor mechanisms. A model based on the above data is presented.

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