Profiles of in vivo Gamma-Aminobutyric Acid Release in the Medial Preoptic Area of Intact and Castrated Male Rats

2002 ◽  
Vol 76 (5) ◽  
pp. 290-296 ◽  
Author(s):  
T Tin-Tin-Win-Shwe ◽  
Dai Mitsushima ◽  
Fukuko Kimura
Keyword(s):  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Aminobutyric Acid ◽  
Male Rats ◽  
Gamma Aminobutyric Acid ◽  
Acid Release

Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats

1998 ◽  
Vol 274 (1) ◽  
pp. R243-R247 ◽  
Author(s):  
Yoshikazu Sato ◽  
Hiroki Horita ◽  
Toshie Kurohata ◽  
Hideki Adachi ◽  
Taiji Tsukamoto
Keyword(s):  
Nitric Oxide ◽  
Preoptic Area ◽  
Copulatory Behavior ◽  
Medial Preoptic Area ◽  
In Vivo Microdialysis ◽  
Male Rats ◽  
Nitric Oxide Level ◽  
Synthase Inhibitor ◽  
Male Copulatory Behavior

We investigated the influence of the extracellular nitric oxide (NO) level on male copulatory behavior. We confirmed the changes of nitrite ([Formula: see text]) and nitrate ([Formula: see text]) in the medial preoptic area (MPOA) by administration of the NO precursorl-arginine (l-Arg, 10 mM) or the NO synthase inhibitor N G-monomethyl-l-arginine (l-NMMA, 10 mM) via a dialysis probe. [Formula: see text] and[Formula: see text] were measured simultaneously by an in vivo microdialysis method coupled with the Griess reaction.l-Arg induced significant elevations of extracellular [Formula: see text]and [Formula: see text].l-NMMA significantly reduced[Formula: see text] and[Formula: see text] levels. We observed male copulatory behavior during infusion ofl-Arg orl-NMMA. The mount rate of male rats significantly increased during infusion ofl-Arg in the MPOA. Administration of l-NMMA reduced the mount rate. These findings suggested that the elevation of extracellular NO in the MPOA facilitates male copulatory behavior of rats, whereas the decrease of NO reduces their copulatory behavior.

Pyridoxine and GABA as antagonists to drug-induced convulsions in monkeys

1965 ◽  
Vol 20 (6) ◽  
pp. 1337-1340 ◽  
Author(s):  
Lenore M. Kopeloff ◽  
Joseph G. Chusid
Keyword(s):  
Macaca Mulatta ◽  
Vitamin B6 ◽  
Aminobutyric Acid ◽  
Experimental Epilepsy ◽  
Protective Effects ◽  
Gamma Aminobutyric Acid ◽  
Drug Induced

The antagonistic properties of pyridoxine and gamma aminobutyric acid (GABA) toward convulsant drugs were evaluated by determining their in vivo protective effects when administered parenterally prior to challenge. In a group of 28 monkeys composed of 19 chronic epileptics and 9 controls, pyridoxine and GABA provided variable grades of protection against the convulsant actions of methoxypyridoxine, semicarbazide, and to a lesser degree, pentamethylenetetrazol (Metrazol) and 3,3-methylethylglutarimide (Megimide). Neither pyridoxine nor GABA protected epileptic, brain-operated nonepileptic, or normal monkeys from the convulsant actions of parenteral picrotoxin. No evidence therefore was found in these experiments to support the suggestion that GABA (or pyridoxine) and picrotoxin are antagonistic to each other. experimental epilepsy in Macaca mulatta; gamma aminobutyric acid and vitamin B6 as anticonvulsants Submitted on February 15, 1965

Gamma-Aminobutyric Acid and Dysregulation of TSH Secretion in Uremic Male Rats

Nephron ◽  
1987 ◽  
Vol 46 (3) ◽  
pp. 301-304 ◽  
Author(s):  
Alan N. Elias ◽  
Nosratola D. Vaziri ◽  
M.R. Pandian ◽  
Krish Iyer ◽  
Mohammad A. Ansari
Keyword(s):  
Aminobutyric Acid ◽  
Male Rats ◽  
Gamma Aminobutyric Acid ◽  
Tsh Secretion
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