Effects of Interrupting Intravenous Saline Infusion on Sodium Excretion in the Dog

1978 ◽  
Vol 1 (1) ◽  
pp. 11-18
Author(s):  
V.M. Buckalew, jr ◽  
T.G. Adkins
Keyword(s):  
Sodium Excretion ◽  
Saline Infusion ◽  
Intravenous Saline

scholarly journals Dr Thomas Latta: the father of intravenous infusion therapy

2009 ◽  
Vol 10 (1_suppl) ◽  
pp. S3-S6 ◽  
Author(s):  
Neil MacGillivray
Keyword(s):  
Twentieth Century ◽  
Intravenous Infusion ◽  
Medical Profession ◽  
Saline Infusion ◽  
Infusion Therapy ◽  
Cholera Epidemic ◽  
New Therapy ◽  
Intravenous Saline

The paper reviews the work of Dr Thomas Latta who during the cholera epidemic of 1831—32 pioneered the use of intravenous saline infusion in the treatment of cholera. The reaction of the medical profession to this new therapy is described and the reasons for the profession’s failure to acknowledge the importance of this advance is analysed. The reasons why the name of Thomas Latta and his contribution did not survive his death in 1833 are discussed and the contributions of twentieth century scholars in remembering his work are highlighted.

scholarly journals Pulmonary gas exchange following rapid intravenous saline infusion

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
G. Kim Prisk ◽  
I. Mark Olfert ◽  
Tatsuya J Arai ◽  
Richard M Hinds ◽  
Kun Lun Huang ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Pulmonary Gas Exchange ◽  
Saline Infusion ◽  
Intravenous Saline

Indication of Treatment For Children And Adolescents With Postural Tachycardia Syndrome By Intravenous Saline Infusion

2022 ◽  
Author(s):  
Yoshitoki Yanagimoto ◽  
Yuko Ishizaki ◽  
Yoko Nakai ◽  
Miki Minami ◽  
Rinako Tamai ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Comparison Group ◽  
Intervention Group ◽  
Saline Infusion ◽  
Postural Tachycardia Syndrome ◽  
Postural Tachycardia ◽  
Before And After ◽  
Intravenous Saline ◽  
The Mean ◽  
Standing Test

Abstract Background: Intravenous saline infusion is considered effective for the treatment of postural tachycardia syndrome (POTS) in adults. However, few studies have assessed the efficacy of intravenous saline infusion for POTS in children and adolescents. Aim: This study aimed to evaluate the efficacy of intravenous saline infusion in children and adolescents with POTS.Methods: A total of 107 children with POTS (median age: 13 years, range: 10–15 years) were enrolled. Eighty-eight children were in the intravenous saline infusion group and 19 children were in the comparison group. Blood pressure (BP) and pulse rate (PR) were recorded before and after standing. A standing test was performed early in the morning for 2 consecutive days. A volume of 1.5 L of saline was administered intravenously to each participant in the intervention group for a mean duration of 17 hours between the two standing tests.Results: The mean change in PR was significantly lower in the intervention group than in the comparison group during the second test (36.9 vs. 52.8 beats/minute, p<0.001). Additionally, the mean change in PR was significantly lower in the second test than in the first test (44.7 beats/minute) in the intervention group (p<0.001). However, the mean change in systolic BP was not different before and after intravenous saline infusion between the two groups or between the two tests in each group.Conclusion: Intravenous saline infusion reduces the increased PR on standing in children with POTS. Intravenous saline infusion improves tachycardia in children with POTS when standing.

Renal blood flow, sodium excretion, and concentrating ability during saline infusion

1966 ◽  
Vol 211 (5) ◽  
pp. 1181-1186 ◽  
Author(s):  
A Shuster ◽  
EA Alexander ◽  
RC Lalone ◽  
NG Levinsky
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Sodium Excretion ◽  
Saline Infusion

SODIUM EXCRETION IN THE ADRENALECTOMIZED RAT AFTER INTRAVENOUS SALINE INFUSION

1960 ◽  
Vol 20 (2) ◽  
pp. 112-122 ◽  
Author(s):  
C. J. EDMONDS
Keyword(s):  
Sodium Excretion ◽  
Tubular Reabsorption ◽  
Similar Extent ◽  
Sodium Potassium ◽  
Water Load ◽  
Initial Rise ◽  
Intravenous Saline ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular ◽  
Adrenalectomized Rats

SUMMARY The excretion of sodium, potassium and water, and the changes of glomerular filtration rate (g.f.r.) in response to intravenous infusions of hypertonic saline have been studied in normal and adrenalectomized rats. The increase in sodium excretion in response to infusion was considerably depressed after adrenalectomy. It was not restored to normal by cortisone or cortisol administration, although the adrenalectomized rats treated with these steroids were able to excrete water after a water load as rapidly as normal rats. Potassium excretion was increased to a similar extent by the infusions in both normal and adrenalectomized rats. g.f.r. rose in both groups during the infusion but the rise was depressed by adrenalectomy. In both normal and adrenalectomized rats treated with cortisone, g.f.r. remained elevated throughout the infusion, but the initial rise was less rapid in the latter than in the normal animals. In adrenalectomized rats maintained on 1% saline only, the rise of g.f.r. was not sustained and by the 4th hr of infusion had fallen to the pre-infusion level. When i.v. cortisol was given immediately before the infusion, the initial rise of g.f.r. was restored to normal. Comparison of the changes of g.f.r. with those of sodium excretion suggested that impairment of sodium excretion during the infusions was due, in part at least, to a change in renal tubular reabsorption of sodium following adrenalectomy.

Comparison of the Effects on Urinary Sodium Excretion of Indomethacin and of Carbidopa in normal Volunteers given an Intravenous Saline Infusion

1997 ◽  
Vol 92 (4) ◽  
pp. 409-414
Author(s):  
G. S. Stokes ◽  
J. C. Monaghan ◽  
D. N. Pillai
Keyword(s):  
Volume Expansion ◽  
Randomized Study ◽  
Plasma Concentrations ◽  
Urinary Sodium Excretion ◽  
Saline Infusion ◽  
Normal Volunteers ◽  
Intravenous Saline ◽  
Urinary Dopamine ◽  
Natriuretic Effect ◽  
Renal Tubular

1. Dopamine and prostaglandins are putative endogenous natriuretic hormones. The role of each in facilitating natriuresis induced by intravenous saline infusion was examined in normal volunteers in relation to administration of carbidopa, a dopadecarboxylase inhibitor, and indomethacin, an inhibitor of prostaglandin synthetase. 2. In a placebo-controlled, randomized study, 13 subjects received carbidopa (100 mg) and 12 received indomethacin (50 mg). Proximal and distal renal tubular Na+ reabsorption were determined using exogenous lithium clearance. 3. On the control day, 2 litres of 0.9% saline (308 mmol Na+) given intravenously in 3 h, resulted in volume expansion and natriuresis. Carbidopa reduced the urinary dopamine/noradrenaline ratio but showed no anti-natriuretic effect and no effect on fractional Na+ reabsorption. Indomethacin diminished natriuresis and increased distal fractional Na+ reabsorption in proportion to the anti-natriuretic effect. 4. The changes in plasma concentrations of albumin, aldosterone, atrial natriuretic peptide and renin activity associated with volume expansion were not modified by either carbidopa or indomethacin. Urinary prostaglandin E2 excretion was decreased transiently by indomethacin and was unaffected by carbidopa. 5. This study suggests that prostaglandins may modulate urinary Na+ excretion during saline-induced natriuresis through inhibition of distal tubular Na+ reabsorption. No role for free dopamine as a modulator of renal Na+ handling could be assigned on the basis of the findings with carbidopa.

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