Calcium Mass Balance and Behavior of Intact Immunoreactive Parathyroid Hormone in Acetate-Free Biofiltration: Acute and One-Year Evaluation

1994 ◽  
Vol 12 (2) ◽  
pp. 85-94 ◽  
Author(s):  
A. de Vincenzi ◽  
R. Bellazzi ◽  
M. Santagostino ◽  
D. Romanini ◽  
M. Nai ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Mass Balance ◽  
One Year ◽  
And Behavior ◽  
Immunoreactive Parathyroid Hormone

PARATHYROID HORMONE SECRETION IN DISORDERS OF CALCIUM METABOLISM STUDIED BY MEANS OF EDTA

1974 ◽  
Vol 75 (2) ◽  
pp. 286-296 ◽  
Author(s):  
J. H. Lockefeer ◽  
W. H. L. Hackeng ◽  
J. C. Birkenhäger
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Calcium Metabolism ◽  
Hormone Secretion ◽  
Parathyroid Tissue ◽  
Small Mass ◽  
Idiopathic Hypercalciuria ◽  
List Type ◽  
Immunoreactive Parathyroid Hormone ◽  
Pth Level

ABSTRACT In 22 of 28 cases of primary hyperparathyroidism (PHP) the rise in the serum immunoreactive parathyroid hormone (IRPTH or PTH) level observed in response to lowering of the serum calcium by EDTA, exceeded that obtained in 8 control subjects. In 5 of these 22 patients who were studied again after parathyroidectomy the supranormal response was abolished. Fifteen of these 22 hyper-responsive PHP patients had basal IRPTH levels not exceeding the highest level in the controls and that of other groups of patients investigated (idiopathic hypercalciuria, non-parathyroid hypercalcaemia, operated PHP). Fourteen of the 22 hyper-reactive patients with PHP did not show hypocalcaemia during the infusion of EDTA. The extent of the release of PTH elicited by EDTA in cases of PHP does not as yet allow a prediction of the amount of pathological parathyroid tissue present, although all the PHP patients showing a normal release of PTH had a relatively small mass of parathyroid tissue (up to about 1 g) subsequently removed. In 9 cases of nephrolithiasis (8 of whom had idiopathic hypercalciuria) and in 7 cases of non-parathyroid hypercalcaemia, a normal PTH release was found.

ENDOCRINE EFFECTS OF LITHIUM:

1978 ◽  
Vol 88 (3) ◽  
pp. 528-534 ◽  
Author(s):  
C. Christiansen ◽  
P. C. Baastrup ◽  
P. Lindgreen ◽  
I. Transbøl
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Serum Calcium ◽  
Lithium Treatment ◽  
Serum Magnesium ◽  
Endocrine Effects ◽  
Manic Depressive ◽  
Depressive Patients ◽  
Immunoreactive Parathyroid Hormone

ABSTRACT Ninety-six manic-depressive patients were studied during long-term lithium treatment. Highly significant elevations were observed respecting the levels of serum immunoreactive parathyroid hormone (P < 0.001) as well as the protein-corrected levels of serum calcium (P < 0.001) and serum magnesium (P <0.001), thus indicating a state of 'primary' hyperparathyroidism. The patients as a group had normophosphataemia and normophosphatasia supporting the impression of a rather mild state of biochemical hyperparathyroidism.

Regulation of parathyroid hormone secretion by plasma calcium in aging rats

1991 ◽  
Vol 260 (2) ◽  
pp. E220-E225 ◽  
Author(s):  
J. Fox
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Secretion ◽  
Fold Increase ◽  
Male Rats ◽  
Aged Rats ◽  
Adult Rats ◽  
Dihydroxyvitamin D3 ◽  
Set Point ◽  
Skeletal Resistance ◽  
Immunoreactive Parathyroid Hormone

Plasma immunoreactive parathyroid hormone (irPTH) levels increase with aging. This study determined 1) whether NH2-terminal irPTH secretory responses to induced hypocalcemia differ between adult (6-mo-old) and aged (24- to 26-mo-old) male rats and 2) whether a higher set point for irPTH release by Ca is responsible for the elevated irPTH levels with aging. Basal irPTH levels were 68% higher and 1,25-dihydroxyvitamin D3 levels were 44% lower in aged rats. An acutely induced, constant hypocalcemic stimulus [0.32 mM decrement in ionized Ca (Ca2+) for 2 h] was developed in catheterized conscious adult and aged rats by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) infusion using the Ca clamp technique. The initial irPTH secretory response to acute hypocalcemia (5-10 min) was reduced in aged rats (1.9- vs. 3.1-fold increase), suggesting reduced hormone stores. However, higher sustained irPTH levels (30 min to 2 h) were maintained in aged rats, indicating increased irPTH synthesis and release. The EGTA infusion rate necessary to maintain constant hypocalcemia was less in aged rats, suggesting skeletal resistance to PTH. Slow EGTA and Ca infusions were used to determine irPTH secretion at plasma Ca2+ levels from 0.7 to 1.5 mM. In aged rats, irPTH levels were higher at all Ca2+ concentrations, but the set point for irPTH release by Ca2+ was the same as in adult rats. Thus the elevated irPTH secretion in aged rats is not caused by a change in the set point for irPTH release but does result in decreased irPTH stores.

Pregnancy decreases immunoreactive parathyroid hormone level in rats with chronic renal failure

1999 ◽  
Vol 96 (4) ◽  
pp. 427-430 ◽  
Author(s):  
M. BLUM ◽  
Y. WEISMAN ◽  
S. TURGEMAN ◽  
S. CABILI ◽  
Y. WOLLMAN ◽  
...  
Keyword(s):  
Renal Failure ◽  
Parathyroid Hormone ◽  
Chronic Renal Failure ◽  
Virgin Female ◽  
Normal Pregnancy ◽  
High Serum ◽  
Female Rats ◽  
Pregnant Rats ◽  
Serum Ipth ◽  
Immunoreactive Parathyroid Hormone

Normal pregnancy is associated with an increase in serum parathyroid hormone and 1,25-dihydroxyvitamin D3 (calcitriol). The effect of pregnancy on these hormones in chronic renal failure (CRF) is unknown. The present work was undertaken to study the changes of serum immunoreactive parathyroid hormone (iPTH) and calcitriol in pregnant rats with CRF. The following experimental groups were studied: CRF1 (5/6 nephrectomized virgin female rats), CRF2 (5/6 nephrectomized pregnant rats at day 20–21 of pregnancy), CRF3 (5/6 nephrectomized rats 2 weeks after delivery) and their respective sham-operated control groups: N1, N2 and N3. The 5/6 nephrectomy (CRF1) resulted in renal failure with very high serum iPTH (100±18 pg/ml) and low calcitriol levels (10.6±4.3 pg/ml) compared with normal rats [N1: 14±2.5 pg/ml (P< 0.001) and 18.2±4.2 pg/ml (P< 0.01) respectively]. The pregnancy in CRF rats (CRF2) resulted in normalization of serum iPTH levels (18.2±5.41 pg/ml), which was associated with a parallel increase in serum calcitriol (29.4±8.0 pg/ml) similar to that in pregnancy of normal rats (N2). Two weeks after delivery the CRF rats (CRF3) once again had high serum iPTH (87±17 pg/ml) and low calcitriol levels (9.3±1.2 pg/ml), similar to those observed in non-pregnant uraemic rats (CRF1). It is concluded that pregnancy decreases serum iPTH in 5/6 nephrectomized CRF rats most probably by the increased level of calcitriol synthesized by the feto-placental unit.

scholarly journals Consequences of the experimental removal of Sabella spallanzanii (Gmelin, 1791) from the fouling assemblage of a Mediterranean harbour

2019 ◽  
Vol 20 (3) ◽  
pp. 476 ◽  
Author(s):  
CATALDO PIERRI ◽  
PAOLO COLANGELO ◽  
MICHELA DEL PASQUA ◽  
CATERINA LONGO ◽  
ADRIANA GIANGRANDE
Keyword(s):  
Empty Space ◽  
Fouling Communities ◽  
Ecological Processes ◽  
Sessile Invertebrates ◽  
One Year ◽  
Fouling Assemblages ◽  
And Behavior ◽  
Reduced Water ◽  
Sampling Times ◽  
Relevant Component

Filter feeding invertebrates are a relevant component of fouling assemblages with a pivotal role in ecological processes, since they improve water quality, enhance habitat heterogeneity and transfer organic matter from the water column to the benthos. They modulate the availability of resources to other species, with effects on the density and behavior of the surrounding macrofauna. The fanworm Sabella spallanzanii, one of the largest and most abundant Mediterranean filter feeders, provides a shelter for predation and a secondary substrate for algae and settlement for sessile invertebrates. We tested its role in driving the structure of fouling assemblages, through a removal experiment.The experiment was one-year-long, with four sampling times. The effect of the removal on the fouling community was marginal in terms of species richness and evenness, while the biomass showed important differences, with a constant increase over time with higher values in the samples containing S. spallanzanii. At the end of observations, the biomass reached the value of 3917 g DW m-2 in controls and 2073 g DW m-2 in treatments. The empty space left by fanworms was not used by other species with similar biomasses. It is possible that the functioning of fouling communities may, in the event of loss of species, fluctuate in terms of biomass mobilization to different compartments, either towards the pelagic compartment or to the detritus chain. In systems with reduced water turnover, this by-pass can have important consequences in terms of stability and ecological balance.

The Arterio-Venous Difference for Immunoreactive Parathyroid Hormone and the Production of Adenosine 3′,5′-Monophosphate by Isolated Perfused Bone: Studies with Analogs of Parathyroid Hormone*

Endocrinology ◽  
1981 ◽  
Vol 109 (3) ◽  
pp. 956-959 ◽  
Author(s):  
KEVIN J. MARTIN ◽  
EZEQUIEL BELLORIN-FONT ◽  
JEFFREY FREITAG ◽  
MICHAEL ROSENBLATT ◽  
EDUARDO SLATOPOLSKY
Keyword(s):  
Parathyroid Hormone ◽  
Immunoreactive Parathyroid Hormone

P4. Plasma immunoreactive parathyroid hormone (PTH) concentration in the detection of osteomalacia (OM) in asian out-patients

Bone ◽  
1988 ◽  
Vol 9 (4) ◽  
pp. 261-261
Author(s):  
JA Nisbet ◽  
AM Flanagan ◽  
L Ang ◽  
KW Golston ◽  
TJ Chambers ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Immunoreactive Parathyroid Hormone

Factors Influencing Time to Decrease in Intraoperative Parathyroid Hormone (ioPTH) Levels in Patients Undergoing Focused Parathyroidectomy (FP)

2018 ◽  
Vol 84 (6) ◽  
pp. 772-775 ◽  
Author(s):  
Neal Bhutiani ◽  
Beunca Graffree ◽  
Robert C.G. Martin ◽  
Amy R. Quillo
Keyword(s):  
Parathyroid Hormone ◽  
Normal Range ◽  
Factors Affecting ◽  
Time Period ◽  
Lower Baseline ◽  
Focused Parathyroidectomy ◽  
Potential Factors ◽  
One Year ◽  
Intraoperative Parathyroid Hormone ◽  
Cure Rates

The aim of this study was to evaluate potential factors affecting the time period in which a 50 per cent parathyroid hormone (PTH) drop is observed. Eight-seven patients undergoing focused parathyroidectomy between 2011 and 2015, whose PTH values dropped to within normal range, were grouped according to whether they required > or ≤15 minutes after gland excision to achieve a 50 per cent PTH. Groups were compared according to preoperative PTH, calcium, age, glomer-ular filtration rate, and adenoma weight. Lower preoperative and preincision PTH levels were associated with requiring >15 minutes to achieve a >50 per cent drop in ioPTH. Time to >50 per cent ioPTH drop did not affect cure rates at one year, though a >15 minutes requirement was associated with higher serum calcium levels (P = 0.015). Lower baseline PTH and preincision PTH levels are significantly associated with a >15 minutes postexcision time to achieve a >50 per cent drop in ioPTH. Future analyses are warranted to determine whether a longer postexcision time threshold before proceeding with four-gland exploration is warranted in patients with primary hyperparathyroidism and mildly elevated preoperative PTH.

Management of Completion and Total Thyroidectomy Patients Based on 1-Hour Postoperative Parathyroid Hormone

2016 ◽  
Vol 82 (10) ◽  
pp. 881-884
Author(s):  
Joshua Park ◽  
Ethan Frank ◽  
Alfred Simental ◽  
Sara Yang ◽  
Christopher Vuong ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Total Thyroidectomy ◽  
Early Discharge ◽  
Vitamin D Supplementation ◽  
Initial Management ◽  
Management Protocol ◽  
Symptomatic Hypocalcemia ◽  
Risk Patients ◽  
One Year

After thyroid surgery, protocols based on postoperative parathyroid hormone (PTH) levels may prevent symptoms of hypocalcemia, while avoiding unnecessary prophylactic calcium and/or vitamin D supplementation. We examined the value of an initial management protocol based solely on a single PTH level measured one hour after completion or total thyroidectomy to prevent symptomatic hypocalcemia by conducting a retrospective review of 697 consecutive patients treated from July 2003 to April 2015. The proportion of patients who developed symptomatic hypocalcemia was similar between those treated before (n = 155) and after (n = 542) implementation of this 1-hour PTH protocol (16.8% vs 15.9%; P = 0.786). Those in the 1-hour PTH groups had lower overnight observation rates (97.4% vs 53.7%; P < 0.001) and length of stay (1.98 ± 2.61 vs 0.89 ± 1.87 days; P < 0.001), and required less calcium (3.9% vs 0.8%; P = 0.015) and vitamin D (2.6% vs 0%; P = 0.002) supplementation one year after surgery. Less than 1 per cent of patients discharged on the day of surgery in accordance with the 1-hour PTH guidelines returned to the emergency room for symptomatic hypocalcemia; none experienced significant morbidity. This protocol facilitates early discharge of low-risk patients and results in a similar or improved postoperative course compared with traditional overnight observation.

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