Immunohistochemical Study on the Endocrine Pancreas of Cattle with Special Reference to Coexistence of Serotonin and Glucagon or Bovine Pancreatic Polypeptide

1988 ◽  
Vol 131 (3) ◽  
pp. 235-240 ◽  
Author(s):  
Seigo Nakajima ◽  
Nobuo Kitamura ◽  
Junzo Yamada ◽  
Tadayuki Yamashita ◽  
Tohru Watanabe
Keyword(s):  
Special Reference ◽  
Pancreatic Polypeptide ◽  
Endocrine Pancreas ◽  
Immunohistochemical Study ◽  
Bovine Pancreatic Polypeptide

Effects of somatostatin and pancreatic polypeptide on exocrine and endocrine pancreas in the rats

1988 ◽  
Vol 23 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Wontae Lee ◽  
Kazunori Miyazaki ◽  
Akihiro Funakoshi
Keyword(s):  
Pancreatic Polypeptide ◽  
Endocrine Pancreas

A Suboesophageal Ganglion Cell Innervates Heart and Retrocerebral Glandular Complex in the Locust

1991 ◽  
Vol 156 (1) ◽  
pp. 567-582
Author(s):  
PETER BRÄUNIG
Keyword(s):  
Pancreatic Polypeptide ◽  
Nerve Cord ◽  
Sagittal Plane ◽  
Locusta Migratoria ◽  
Neurosecretory Cells ◽  
Double Labelling ◽  
Suboesophageal Ganglion ◽  
Migratory Locust ◽  
Bovine Pancreatic Polypeptide ◽  
Thoracic And Abdominal

The suboesophageal ganglion of the migratory locust Locusta migratoria contains a pair of large neurosecretory cells located posteriorly, close to the sagittal plane. By means of double labelling, it is shown that the cells are immunoreactive to bovine pancreatic polypeptide. Using a combination of electrophysiological, neuroanatomical and immunocytochemical methods, it is shown that the neurones project into the corpora cardiaca with ascending anterior axons and into the lateral cardiac nerve cords with posterior axons that descend into the thoracic and abdominal nerve cord.

Bovine pancreatic polypeptide as an antagonist of muscarinic cholinergic receptors

1987 ◽  
Vol 252 (3) ◽  
pp. G384-G391
Author(s):  
G. Z. Pan ◽  
L. Lu ◽  
J. M. Qian ◽  
B. G. Xue
Keyword(s):  
Pancreatic Polypeptide ◽  
Pancreatic Enzyme ◽  
Cholinergic Receptors ◽  
Enzyme Secretion ◽  
Amylase Secretion ◽  
Enzyme Release ◽  
Muscarinic Cholinergic Receptors ◽  
Bovine Pancreatic Polypeptide ◽  
Pancreatic Enzyme Secretion ◽  
Muscarinic Cholinergic

In dispersed acini from rat pancreas, it was found that bovine pancreatic polypeptide (BPP) and its C-fragment hexapeptide amide (PP-6), at concentrations of 0.1 and 30 microM, respectively, could significantly inhibit amylase secretion stimulated by carbachol (P less than 0.01 or 0.05, respectively), and this inhibition by BPP was dose dependent. 45Ca outflux induced by carbachol was also inhibited by BPP or PP-6, but they had no effect on cholecystokinin octapeptide- (CCK-8) or A23187-stimulated 45Ca outflux. BPP was also capable of displacing the specific binding of [3H]quinuclidinyl benzilate to its receptors, and it possessed a higher affinity (ki 35 nM) than carbachol (Ki 1.8 microM) in binding with M-receptors. It is concluded from this study that BPP acts as an antagonist of muscarinic cholinergic receptors in rat pancreatic acini. In addition, BPP inhibited the potentiation of amylase secretion caused by the combination of carbachol plus secretin or vasoactive intestinal peptide. This may be a possible explanation of the inhibitory effect of BPP on secretin-induced pancreatic enzyme secretion shown in vivo, since pancreatic enzyme secretion stimulated by secretin under experimental conditions may be the result of potentiation of enzyme release produced by the peptide in combination with a cholinergic stimulant.

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