Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization

1997 ◽  
Vol 79 (1-2) ◽  
pp. 143-144 ◽  
Author(s):  
J. Aurich-Costa ◽  
S. Cadel ◽  
C. Gouzy ◽  
T. Foulon ◽  
D. Chérif ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Human Chromosome ◽  
Chromosome 1 ◽  
Human Chromosome 1

scholarly journals Partial trisomy of the long arm of human chromosome 1 as demonstrated by in situ hybridization with 5S ribosomal RNA

1977 ◽  
Vol 36 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Dale M. Steffensen ◽  
Ernest H. Y. Chu ◽  
David P. Speert ◽  
Patrick M. Wall ◽  
Karen Meilinger ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Human Chromosome ◽  
Ribosomal Rna ◽  
Partial Trisomy ◽  
Chromosome 1 ◽  
5S Ribosomal Rna ◽  
Human Chromosome 1

scholarly journals Human U1 small nuclear RNA pseudogenes do not map to the site of the U1 genes in 1p36 but are clustered in 1q12-q22.

1985 ◽  
Vol 5 (9) ◽  
pp. 2172-2180 ◽  
Author(s):  
V Lindgren ◽  
L B Bernstein ◽  
A M Weiner ◽  
U Francke
Keyword(s):  
In Situ Hybridization ◽  
Class I ◽  
Chromosome 1 ◽  
Small Nuclear Rna ◽  
Coding Region ◽  
Cell Biol ◽  
Gene Copies ◽  
Nuclear Rna ◽  
Human Chromosome 1

Human U1 small nuclear RNA is encoded by approximately 30 gene copies. All of the U1 genes share several kilobases of essentially perfect flanking homology both upstream and downstream from the U1 coding region, but remarkably, for many U1 genes excellent flanking homology extends at least 24 kilobases upstream and 20 kilobases downstream. Class I U1 RNA pseudogenes are abundant in the human genome. These pseudogenes contain a complete but imperfect U1 coding region and possess extensive flanking homology to the true U1 genes. We mapped four class I pseudogenes by in situ hybridization to the long arm of chromosome 1, bands q12-q22, a region distinct from the site on the distal short arm of chromosome 1 to which the U1 genes have been previously mapped (Lund et al., Mol. Cell. Biol. 3:2211-2220, 1983; Naylor et al., Somat. Cell Mol. Genet. 10:307-313, 1984). We confirmed our in situ hybridization results by genomic blotting experiments with somatic cell hybrid lines with translocation products of human chromosome 1. These experiments provide further evidence that class I U1 pseudogenes and the true U1 genes are not interspersed. The results, along with those published elsewhere (Bernstein et al., Mol. Cell. Biol. 5:2159-2171, 1985), suggest that gene amplification may be responsible for the sequence homogeneity of the human U1 gene family.

Human U1 small nuclear RNA pseudogenes do not map to the site of the U1 genes in 1p36 but are clustered in 1q12-q22

1985 ◽  
Vol 5 (9) ◽  
pp. 2172-2180 ◽  
Author(s):  
V Lindgren ◽  
L B Bernstein ◽  
A M Weiner ◽  
U Francke
Keyword(s):  
In Situ Hybridization ◽  
Class I ◽  
Chromosome 1 ◽  
Small Nuclear Rna ◽  
Coding Region ◽  
Cell Biol ◽  
Gene Copies ◽  
Nuclear Rna ◽  
Human Chromosome 1

Human U1 small nuclear RNA is encoded by approximately 30 gene copies. All of the U1 genes share several kilobases of essentially perfect flanking homology both upstream and downstream from the U1 coding region, but remarkably, for many U1 genes excellent flanking homology extends at least 24 kilobases upstream and 20 kilobases downstream. Class I U1 RNA pseudogenes are abundant in the human genome. These pseudogenes contain a complete but imperfect U1 coding region and possess extensive flanking homology to the true U1 genes. We mapped four class I pseudogenes by in situ hybridization to the long arm of chromosome 1, bands q12-q22, a region distinct from the site on the distal short arm of chromosome 1 to which the U1 genes have been previously mapped (Lund et al., Mol. Cell. Biol. 3:2211-2220, 1983; Naylor et al., Somat. Cell Mol. Genet. 10:307-313, 1984). We confirmed our in situ hybridization results by genomic blotting experiments with somatic cell hybrid lines with translocation products of human chromosome 1. These experiments provide further evidence that class I U1 pseudogenes and the true U1 genes are not interspersed. The results, along with those published elsewhere (Bernstein et al., Mol. Cell. Biol. 5:2159-2171, 1985), suggest that gene amplification may be responsible for the sequence homogeneity of the human U1 gene family.

scholarly journals The gene encoding decay-accelerating factor (DAF) is located in the complement-regulatory locus on the long arm of chromosome 1.

1987 ◽  
Vol 165 (6) ◽  
pp. 1731-1736 ◽  
Author(s):  
D M Lublin ◽  
R S Lemons ◽  
M M Le Beau ◽  
V M Holers ◽  
M L Tykocinski ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Regulatory Gene ◽  
Factor H ◽  
Host Cells ◽  
Chromosome 1 ◽  
Complement Receptor ◽  
Gene Encoding ◽  
Complement Receptor 1 ◽  
Human Chromosome 1

Delay-accelerating factor (DAF) protects host cells from complement-mediated damage by regulating the activation of C3 convertases on host cell surfaces. Using a panel of hamster-human somatic cell hybrids, the DAF gene was mapped to human chromosome 1. In situ hybridization studies using human metaphase cells further localized the gene to bands 1q31-41, with the largest cluster of grains at 1q32. This establishes the close linkage of the DAF gene to genes for four other proteins (C3b/C4b receptor or complement receptor 1, C3d receptor or complement receptor 2, factor H, and C4-binding protein) that share 60-amino-acid homologous repeats as well as complement-regulatory or -receptor activity, thereby enlarging the complement-regulatory gene family on the long arm of human chromosome 1.

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