Assignment1 of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization

2000 ◽  
Vol 88 (3-4) ◽  
pp. 328-329 ◽  
Author(s):  
D.J Haile
Keyword(s):  
In Situ Hybridization ◽  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 1 ◽  
Mouse Chromosome 1

scholarly journals Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.

1990 ◽  
Vol 172 (1) ◽  
pp. 263-272 ◽  
Author(s):  
M L Watson ◽  
S F Kingsmore ◽  
G I Johnston ◽  
M H Siegelman ◽  
M M Le Beau ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Leukocyte Adhesion ◽  
Evolutionary Relationship ◽  
Coagulation Factor ◽  
Chromosome 1 ◽  
Range Restriction ◽  
Human Chromosome 1 ◽  
Human And Mouse ◽  
Mouse Chromosome 1

A structurally and functionally related group of genes, lymph node homing receptor (LHR), granule membrane protein 140 (GMP-140), and endothelial leukocyte adhesion molecule 1 (ELAM-1) are shown to constitute a gene cluster on mouse and human chromosome 1. In situ hybridization mapped GMP-140 to human chromosome 1 bands 21-24 consistent with chromosomal localization of LHR. Gene linkage analysis in the mouse indicated that these genes and serum coagulation factor V (FV) all map to a region of distal mouse chromosome 1 that is syntenic with human chromosome 1, with no crossovers identified between these four genes in 428 meiotic events. Moreover, long range restriction site mapping demonstrated that these genes map to within 300 kb in both the human and mouse genomes. These data suggest that LHR, ELAM-1, and GMP-140 comprise an adhesion protein family, the selectins, that arose by multiple gene duplication events before divergence of mouse and human. Furthermore, the location of these genes on mouse and human chromosome 1 is consistent with a close evolutionary relationship to the complement receptor-related genes, which also are positioned on the same chromosomes in both species and with which these genes share a region of sequence homology. These data characterize the organization of a genomic region that may be critical for intercellular communication within the immune system.

Comparative Physical and Transcript Maps of ∼1 Mb around loop-tail, a Gene for Severe Neural Tube Defects on Distal Mouse Chromosome 1 and Human Chromosome 1q22–q23

Genomics ◽  
2001 ◽  
Vol 72 (2) ◽  
pp. 180-192 ◽  
Author(s):  
Kit Doudney ◽  
Jennifer N. Murdoch ◽  
Caroline Paternotte ◽  
Louise Bentley ◽  
Simon Gregory ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chromosome 1 ◽  
Distal Mouse Chromosome ◽  
Distal Mouse ◽  
Mouse Chromosome 1

A High-Resolution Genetic, Physical, and Comparative Gene Map of the Doublefoot (Dbf) Region of Mouse Chromosome 1 and the Region of Conserved Synteny on Human Chromosome 2q35

Genomics ◽  
2001 ◽  
Vol 78 (3) ◽  
pp. 197-205 ◽  
Author(s):  
Christopher Hayes ◽  
Andreas Rump ◽  
Matthew R. Cadman ◽  
Mark Harrison ◽  
Edward P. Evans ◽  
...  
Keyword(s):  
High Resolution ◽  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 1 ◽  
Conserved Synteny ◽  
Gene Map ◽  
Mouse Chromosome 1
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