Chromosome polymorphism involving heterochromatic blocks in Chinese hamster chromosome 9

1984 ◽  
Vol 38 (4) ◽  
pp. 257-264 ◽  
Author(s):  
F.A. Ray ◽  
M.F. Bartholdi ◽  
P.M. Kraemer ◽  
L.S. Cram
Keyword(s):  
Chinese Hamster ◽  
Chromosome 9 ◽  
Chromosome Polymorphism ◽  
Chinese Hamster Chromosome

GNAI3, GNAT2, AMPD2, GSTM are clustered in 120 kb of Chinese hamster Chromosome 1q

1996 ◽  
Vol 7 (6) ◽  
pp. 429-432 ◽  
Author(s):  
B. Baron ◽  
M. A. Fernandez ◽  
S. Carignon ◽  
F. Toledo ◽  
G. Buttin ◽  
...  
Keyword(s):  
Chinese Hamster ◽  
Chromosome 1Q ◽  
Chinese Hamster Chromosome

Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5

1982 ◽  
Vol 2 (10) ◽  
pp. 1220-1228
Author(s):  
S Dana ◽  
J J Wasmuth
Keyword(s):  
Human Chromosome ◽  
Mammalian Species ◽  
Chinese Hamster ◽  
Trna Synthetase ◽  
Gene Organization ◽  
Deletion Mapping ◽  
Chromosome 2 ◽  
Chromosome 5 ◽  
Human Chromosome 5 ◽  
Chinese Hamster Chromosome

Chinese hamster-human interspecific hybrid cells, which contain human chromosome 5 and express four genes linked on that chromosome, were subjected to selective conditions requiring them to retain one of the four linked genes, leuS (encoding leucyl-tRNA synthetase), but lose another, either emtB (encoding ribosomal protein S14) or chr. Cytogenetic and biochemical analyses of spontaneous segregants isolated by using these unique selective pressures have enabled us to determine the order and regional location of the leuS, hexB, emtB, and chr genes on human chromosome 5. These segregants arise primarily by terminal deletions of various portions of the long arm of chromosome 5. Our results indicate that the order of at least three of these genes is the same on human chromosome 5 and Chinese hamster chromosome 2. Thus, there appears to be extensive homology between Chinese hamster chromosome 2 and human chromosome 5, which represents an extreme example of the conservation of gene organization between very divergent mammalian species. In addition, these hybrids and selective conditions provide a very simple and quantitative means to assess the potency of various agents suspected of inducing gross chromosomal damage.

scholarly journals c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia.

1983 ◽  
Vol 158 (1) ◽  
pp. 9-15 ◽  
Author(s):  
J Groffen ◽  
N Heisterkamp ◽  
J R Stephenson ◽  
A G van Kessel ◽  
A de Klein ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Chinese Hamster ◽  
Chromosome 9 ◽  
Chromosome 22 ◽  
Chronic Myelocytic Leukemia ◽  
Somatic Cell Hybrids ◽  
Chinese Hamster Cells ◽  
Cell Hybrids ◽  
Myelocytic Leukemia

By analysis of a series of somatic cell hybrids derived by fusion of either mouse or Chinese hamster cells with leukocytes from different chronic myelocytic leukemia (CML) patients or from normal donors, we have localized the human oncogene, c-sis, on the q11 to qter segment of chromosome 22 and demonstrated its translocation from chromosome 22 to chromosome 9 (q34) in CML.

scholarly journals Chromosome Polymorphism and Human Pathology: About 27 Cases of Chromosome 9 Inversion in the Beninese Population

2021 ◽  
Vol 11 (03) ◽  
pp. 23-31
Author(s):  
Simon Azonbakin ◽  
Alfred Ouedraogo ◽  
Alexis Ouedraogo ◽  
Daniel Sewadouno ◽  
Arnaud Agbanlinsou ◽  
...  
Keyword(s):  
Chromosome 9 ◽  
Chromosome Polymorphism ◽  
Human Pathology

Assignment of genes encoding metallothioneins I and II to Chinese hamster chromosome 3: evidence for the role of chromosome rearrangement in gene amplification

1984 ◽  
Vol 4 (12) ◽  
pp. 2932-2936
Author(s):  
R L Stallings ◽  
A C Munk ◽  
J L Longmire ◽  
C E Hildebrand ◽  
B D Crawford
Keyword(s):  
Cell Lines ◽  
Chromosome Rearrangement ◽  
Cdna Probe ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Chromosome 3 ◽  
Chromosome 3P ◽  
Genes Encoding ◽  
Cytogenetic Analyses ◽  
Chinese Hamster Chromosome

Cadmium resistant (Cdr) variants with coordinately amplified metallothionein I and II (MTI and MTII) genes have been derived from both Chinese hamster ovary and near-euploid Chinese hamster cell lines. Cytogenetic analyses of Cdr variants consistently revealed breakage and rearrangement involving chromosome 3p. In situ hybridization with a Chinese hamster MT-encoding cDNA probe localized amplified MT gene sequences near the translocation breakpoint involving chromosome 3p. These observations suggested that both functionally related, isometallothionein loci are linked on Chinese hamster chromosome 3. Southern blot analyses of DNAs isolated from a panel of Chinese hamster X mouse somatic cell hybrids which segregate hamster chromosomes confirmed that both MTI and MTII are located on chromosome 3. We speculate that rearrangement of chromosome 3p could be causally involved with the amplification of MT genes in Cdr hamster cell lines.

scholarly journals Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5.

1982 ◽  
Vol 2 (10) ◽  
pp. 1220-1228 ◽  
Author(s):  
S Dana ◽  
J J Wasmuth
Keyword(s):  
Human Chromosome ◽  
Mammalian Species ◽  
Chinese Hamster ◽  
Trna Synthetase ◽  
Gene Organization ◽  
Deletion Mapping ◽  
Chromosome 2 ◽  
Chromosome 5 ◽  
Human Chromosome 5 ◽  
Chinese Hamster Chromosome

Chinese hamster-human interspecific hybrid cells, which contain human chromosome 5 and express four genes linked on that chromosome, were subjected to selective conditions requiring them to retain one of the four linked genes, leuS (encoding leucyl-tRNA synthetase), but lose another, either emtB (encoding ribosomal protein S14) or chr. Cytogenetic and biochemical analyses of spontaneous segregants isolated by using these unique selective pressures have enabled us to determine the order and regional location of the leuS, hexB, emtB, and chr genes on human chromosome 5. These segregants arise primarily by terminal deletions of various portions of the long arm of chromosome 5. Our results indicate that the order of at least three of these genes is the same on human chromosome 5 and Chinese hamster chromosome 2. Thus, there appears to be extensive homology between Chinese hamster chromosome 2 and human chromosome 5, which represents an extreme example of the conservation of gene organization between very divergent mammalian species. In addition, these hybrids and selective conditions provide a very simple and quantitative means to assess the potency of various agents suspected of inducing gross chromosomal damage.

Sign in / Sign up

Export Citation Format

Share Document