microcell fusion
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2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Masaharu Hiratsuka ◽  
Kana Ueda ◽  
Narumi Uno ◽  
Katsuhiro Uno ◽  
Sayaka Fukuhara ◽  
...  

2003 ◽  
pp. 173-196
Author(s):  
Henriette Gourdeau ◽  
Marsha D. Speevak ◽  
Lucie Jetté ◽  
Mario Chevrette
Keyword(s):  

1997 ◽  
Vol 232 (1) ◽  
pp. 90-96 ◽  
Author(s):  
Heiwa Kanamori ◽  
Jeffrey N. Siegel

1996 ◽  
Vol 16 (9) ◽  
pp. 5048-5057 ◽  
Author(s):  
T A Fiddler ◽  
L Smith ◽  
S J Tapscott ◽  
M J Thayer

One obvious phenotype of tumor cells is the lack of terminal differentiation. We previously classified rhabdomyosarcoma cell lines as having either a recessive or a dominant nondifferentiating phenotype. To study the genetic basis of the dominant nondifferentiating phenotype, we utilized microcell fusion to transfer chromosomes from rhabdomyosarcoma cells into C2C12 myoblasts. Transfer of a derivative chromosome 14 inhibits differentiation. The derivative chromosome 14 contains a DNA amplification. MDM2 is amplified and overexpressed in these nondifferentiating hybrids and in the parental rhabdomyosarcoma. Forced expression of MDM2 inhibits MyoD-dependent transcription. Expression of antisense MDM2 restores MyoD-dependent transcriptional activity. We conclude that amplification and overexpression of MDM2 inhibit MyoD function, resulting in a dominant nondifferentiating phenotype.


1995 ◽  
Vol 6 (2) ◽  
pp. 152-153 ◽  
Author(s):  
K. Islam ◽  
M. Q. Islam ◽  
G. Levan

Author(s):  
Ann McNeill Killary ◽  
R.E.K. Fournier
Keyword(s):  

Genomics ◽  
1990 ◽  
Vol 6 (2) ◽  
pp. 358-366 ◽  
Author(s):  
Dorothy Warburton ◽  
Steven Gersen ◽  
Ming-Tsung Yu ◽  
Cynthia Jackson ◽  
Barbara Handelin ◽  
...  

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