Reticuloendothelial System Phagocytic Function in Obstructive Jaundice and its Modification by a Muramyl Dipeptide Analogue

1987 ◽  
Vol 19 (1) ◽  
pp. 16-22 ◽  
Author(s):  
J.A. Pain ◽  
D.St.J. Collier ◽  
A. Ritson
Keyword(s):  
Obstructive Jaundice ◽  
Muramyl Dipeptide ◽  
Reticuloendothelial System ◽  
Phagocytic Function

The three different phases of reticuloendothelial system phagocytic function in rats with liver injury

1988 ◽  
Vol 45 (3) ◽  
pp. 314-319 ◽  
Author(s):  
Shigeki Arii ◽  
Kazunobu Monden ◽  
Shigeyuki Itai ◽  
Tetsu Sasaoki ◽  
Masafumi Shibagaki ◽  
...  
Keyword(s):  
Liver Injury ◽  
Reticuloendothelial System ◽  
Phagocytic Function

Immunoadjuvants enhance the febrile responses of rats to endogenous pyrogen

1989 ◽  
Vol 67 (5) ◽  
pp. 1734-1739 ◽  
Author(s):  
J. T. Stitt ◽  
S. G. Shimada
Keyword(s):  
Dose Response ◽  
Muramyl Dipeptide ◽  
Reticuloendothelial System ◽  
Response Threshold ◽  
Phagocytic Index ◽  
Sprague Dawley ◽  
Endogenous Pyrogen ◽  
Response Curves ◽  
Maximum Increase ◽  
Fever Response

The febrile responses of male Sprague-Dawley rats to a semipurified endogenous pyrogen produced from human monocytes were characterized by establishing fever dose-response curves. The animals were then injected intravenously with a number of substances that possessed the common properties of stimulating the phagocytic activity of the cells of the reticuloendothelial system and of acting as immunoadjuvants. The substances used were zymosan, lipopolysaccharide endotoxin, and muramyl dipeptide. Three days after any of these immunoadjuvants were injected, the fever sensitivity of the rats was remeasured. In each case, the slope of the fever dose-response curve tripled, and in some instances the response threshold for fever response was reduced by factors of three to eight. Furthermore, the maximum increase in body temperature produced by the endogenous pyrogen was more than doubled after immunoadjuvant treatment. By contrast latex beads, which are also phagocytized by the cells of the reticuloendothelial system but do not subsequently increase their phagocytic index nor do they enhance immune responses, had no effect on the fever sensitivity of rats in response to endogenous pyrogen. In the light of these findings, it is suggested that the febrile responses of rats to endogenous pyrogen are mediated in some manner by cells that possess some of the properties of reticuloendothelial cells. The location of these putative cells must be close to the circulation, because the immunoadjuvants used in this study were, for the most part, large molecular weight molecules that could not cross the blood-brain barrier easily.

Reticuloendothelial system blockade-induced humoral factor depletion and susceptibility to hemorrhagic shock

1978 ◽  
Vol 56 (6) ◽  
pp. 1055-1057 ◽  
Author(s):  
Daniel J. Loegering ◽  
Marlowe J. Schneidkraut
Keyword(s):  
Hemorrhagic Shock ◽  
Host Defense ◽  
Lipid Emulsion ◽  
Reticuloendothelial System ◽  
Humoral Factor ◽  
Phagocytic Index ◽  
Phagocytic Function ◽  
Opsonic Activity ◽  
Circulating Levels ◽  
Increased Susceptibility

This study was carried out to determine if reticuloendothelial system (RES) Mockade-induced depletion of circulating alpha-2-glycoprotein opsonic activity resulted in increased susceptibility to hemorrhagic shock. RES blockade induced by the injection of gelatinized lipid emulsion was associated with a 45.9% decrease in phagocytic index and a 85.7% decrease in plasma alpha-2-glycoprotein opsonic activity. Animals subjected to RES blockade 30 min prior to hemorrhagic shock showed a decrease in time to decompensation and a decrease in maximum shed volume. These results are consistent with the concept that circulating levels of this opsonic protein are important in modulating RES phagocytic function and in host defense to shock.

scholarly journals Reticuloendothelial System Phagocytic Function in Patients with Hodgkin's Disease*

1967 ◽  
Vol 46 (5) ◽  
pp. 855-862 ◽  
Author(s):  
John N. Sheagren ◽  
Jerome B. Block ◽  
Sheldon M. Wolff
Keyword(s):  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Reticuloendothelial System ◽  
Phagocytic Function
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