Effects of Adrenalectomy and Hypertonic Saline on Neuropeptide Y Content in the Posterior Pituitary of the Rat

1993 ◽  
Vol 57 (3) ◽  
pp. 416-421 ◽  
Author(s):  
David S. Jessop ◽  
Philip J. Larsen ◽  
Jens D. Mikkelsen ◽  
Stafford L. Lightman ◽  
Hardial S. Chowdrey
Keyword(s):  
Neuropeptide Y ◽  
Hypertonic Saline ◽  
Posterior Pituitary

The effect of hypertonic saline administration or stalk transection on histamine and histamine N-methyltransferase in the rat posterior pituitary

1986 ◽  
Vol 18 (5-6) ◽  
pp. 494-498 ◽  
Author(s):  
Kenneth M. Verburg ◽  
Ronald R. Bowsher ◽  
Robert L. Zerbe ◽  
David P. Henry
Keyword(s):  
Hypertonic Saline ◽  
Posterior Pituitary ◽  
Saline Administration

Effect of inhibition of nitric oxide synthesis on vasopressin secretion in conscious rabbits

1994 ◽  
Vol 266 (2) ◽  
pp. H822-H828 ◽  
Author(s):  
M. Goyer ◽  
H. Bui ◽  
L. Chou ◽  
J. Evans ◽  
L. C. Keil ◽  
...  
Keyword(s):  
Hypertonic Saline ◽  
Plasma Osmolality ◽  
Plasma Renin ◽  
Saline Infusion ◽  
Posterior Pituitary ◽  
Paraventricular Nuclei ◽  
Plasma Vasopressin ◽  
Vasopressin Secretion ◽  
Posterior Pituitary Gland ◽  
Hypertonic Saline Infusion

NO synthase is present in magnocellular neurons of supraoptic and paraventricular nuclei as well as in the posterior pituitary gland and may participate in control of vasopressin secretion. To test this possibility, experiments were performed in conscious, chronically prepared rabbits to determine the effect of NO synthesis inhibition with NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) on basal vasopressin secretion and vasopressin responses to increased plasma osmolality (hypertonic saline infusion; P osm) and decreased blood pressure (nitroprusside infusion). L-NAME infusion (0.5 mg.kg-1 x min-1 i.v.) increased mean arterial pressure [MAP; 82.6 +/- 3.4 to 93.0 +/- 3.0 mmHg (P < 0.02)], decreased heart rate [HR; 242 +/- 12 to 209 +/- 9 beats/min (P < 0.02)], decreased plasma renin activity [PRA; 3.1 +/- 0.6 to 2.0 +/- 0.6 ng.ml-.2 h-1 (P < 0.001)], and increased plasma vasopressin concentration [P AVP; 2.2 +/- 0.3 to 4.5 +/- 1.0 pg/ml (P < 0.05)]. P(osm) did not change. Hypertonic saline infusion did not change MAP or HR but decreased PRA [4.3 +/- 0.8 to 0.9 +/- 0.2 ng.ml-1 x 2 h-1 (P < 0.01)], increased P(osm) [284 +/- 1 to 305 +/- 2 mosmol/kg H2O (P < 0.001)], and increased PAVP [2.8 +/- 0.3 to 12.7 +/- 2.7 pg/ml (P < 0.01)].(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Posterior pituitary function in Sheehan’s syndrome

2007 ◽  
Vol 156 (5) ◽  
pp. 563-567 ◽  
Author(s):  
Hulusi Atmaca ◽  
Fatih Tanriverdi ◽  
Cumali Gokce ◽  
Kursad Unluhizarci ◽  
Fahrettin Kelestimur
Keyword(s):  
Diabetes Insipidus ◽  
Hypertonic Saline ◽  
Saline Infusion ◽  
Pituitary Function ◽  
Control Group ◽  
Posterior Pituitary ◽  
Infusion Test ◽  
Sheehan’S Syndrome ◽  
Sheehan's Syndrome ◽  
Hypertonic Saline Infusion

Objective: We studied posterior pituitary function in 27 patients with Sheehan’s syndrome and 14 controls. Design: All patients were investigated by water deprivation test and 26 of them by 5% hypertonic saline infusion test. None of the patients had symptoms of diabetes insipidus and all patients were on adequate glucocorticoid and thyroid hormone replacement therapy before testing. Results: According to dehydration test, 8 (29.6%) patients had partial diabetes insipidus (PDI group) and 19 (70.3%) had normal response (non-DI group). During the 5% hypertonic saline infusion test, the maximal plasma osmolality was higher in PDI (305 ± 4.3) and non-DI (308 ± 1.7) groups when compared with controls (298 ± 1.7 mOsm/kg; P < 0.005), but the maximal urine osmolality was lower in PDI group (565 ± 37) than in non-DI (708 ± 45) and control (683 ± 17 mOsm/kg) groups (P < 0.05). The osmotic threshold for thirst perception was higher in PDI (296 ± 4.3) and non-DI (298 ± 1.4) groups when compared with control group (287 ± 1.5 mOsm/kg) (P < 0.005). Basal plasma osmolalities were also higher in PDI (294 ± 1.0) and non-DI (297 ± 1.1) groups than in controls (288 ± 1.2 mOsm/kg; P < 0.001). Conclusions: Our findings demonstrated that patients with Sheehan’s syndrome have an impairment of neurohypophyseal function. The thirst center may be affected by ischemic damage and the osmotic threshold for the onset of thirst in patients with Sheehan’s syndrome is increased.

scholarly journals Hypertonic saline test for the investigation of posterior pituitary function

1998 ◽  
Vol 79 (5) ◽  
pp. 431-434 ◽  
Author(s):  
A. Mohn ◽  
C. L Acerini ◽  
T. D Cheetham ◽  
S. L Lightman ◽  
D. B Dunger
Keyword(s):  
Hypertonic Saline ◽  
Pituitary Function ◽  
Posterior Pituitary ◽  
Saline Test

Physiological and hypertonic saline solutions impair ciliary activity in vitro

2000 ◽  
Vol 25 (4) ◽  
pp. 331-332
Author(s):  
W.M. Boek ◽  
N. Keles ◽  
K. Graamans ◽  
E.H. Huizing
Keyword(s):  
Hypertonic Saline ◽  
Ciliary Activity ◽  
Saline Solutions
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