Quantitative autoradiographic localization of neuropeptide Y (NPY) binding sites in rat posterior pituitary lobe

1988 ◽  
Vol 8 (3) ◽  
pp. 333-338 ◽  
Author(s):  
Juan M. Saavedra ◽  
Ricardo Cruciani
1934 ◽  
Vol 30 (6) ◽  
pp. 634-634
Author(s):  
P. Badul

The posterior lobe of the pituitary gland in a bull is free of prolan, while in a human it contains prolan. Only here it can be found in that part of the posterior pituitary lobe adjacent to the anterior lobe. In the bull, too, this part of the pituitary gland is completely free of prolan content. Histological examination shows that in humans, this part of the posterior lobe is crossed by bands of cells from the anterior lobe, which consist exclusively of basophilic cells.


1993 ◽  
Vol 57 (3) ◽  
pp. 416-421 ◽  
Author(s):  
David S. Jessop ◽  
Philip J. Larsen ◽  
Jens D. Mikkelsen ◽  
Stafford L. Lightman ◽  
Hardial S. Chowdrey

Author(s):  
R. Quirion ◽  
J.C. Martel ◽  
Y. Robitaille ◽  
P. Etienne ◽  
P. Wood ◽  
...  

Abstract:Multiple neurotransmitter systems are affected in senile dementia of the Alzheimer's type (SDAT). Among them, acetylcholine has been most studied. It is now well accepted that the activity of the enzyme, choline acetyltransferase (ChAT) is much decreased in various brain regions including the frontal and temporal cortices, hippocampus and nucleus basalis of Meynert (nbm) in SDAT. Cortical M2-muscarinic and nicotinic cholinergic receptors are also decreased but only in a certain proportion (30-40%) of SDAT patients. For other systems, it appears that cortical serotonin (5-HT)-type 2 receptor binding sites are decreased in SDAT. This diminution in 5-HT2 receptors correlates well with the decreased levels of somatostatin-like immunoreactive materials found in the cortex of SDAT patients. Cortical somatostatin receptor binding sites are decreased in about one third of SDAT patients. Finally, neuropeptide Y and neuropeptide Y receptor binding sites are distributed in areas enriched in cholinergic cell bodies and nerve fiber terminals and it would be of interest to determine possible involvement of this peptide in SDAT. Thus, it appears that multi-drug clinical trials should be considered for the treatment of SDAT.


1957 ◽  
Vol 15 (4) ◽  
pp. 366-373 ◽  
Author(s):  
T. R. BRADLEY ◽  
G. M. MITCHELL

SUMMARY Slices cut from mammary glands of rats and mice during gestation and lactation were incubated in vitro in the presence of pig posterior pituitary lobe extracts rich in melanophore-dispersing ('B') activity. Slices taken in early lactation but not during gestation or late lactation showed increased net gas evolution compared with control slices. Similar tissue from rabbits and guinea-pigs did not give rise to this effect, nor did slices of other tissues taken from lactating rats. The increased net gas evolution was not observed in the absence of glucose from the incubation medium. Treatment of the 'B' extract with NaOH or hypophysectomy of the rats prior to use decreased the response.


1988 ◽  
Vol 48 (2) ◽  
pp. 207-210 ◽  
Author(s):  
Tichomir Torda ◽  
Ricardo A. Cruciani ◽  
Juan M. Saavedra

1987 ◽  
Vol 43 ◽  
pp. 127
Author(s):  
Tatsunobu Okubo ◽  
Yoshihide Ishida ◽  
Yasufumi Kataoka ◽  
Kazuto Shigematsu ◽  
Masami Niwa ◽  
...  

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