Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

2007 ◽  
Vol 106 (4) ◽  
pp. e122-e128 ◽  
Author(s):  
Deepa Sankaran ◽  
Neda Bankovic-Calic ◽  
Leah Cahill ◽  
Claudia Yu-Chen Peng ◽  
Malcolm R Ogborn ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Dietary Intervention ◽  
Polycystic Kidney ◽  
Flax Oil

scholarly journals Lack of Benefit of Early Intervention with Dietary Flax and Fish Oil and Soy Protein in Orthologous Rodent Models of Human Hereditary Polycystic Kidney Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155790 ◽  
Author(s):  
Tamio Yamaguchi ◽  
Jessay G. Devassy ◽  
Md Monirujjaman ◽  
Melissa Gabbs ◽  
Harold M. Aukema
Keyword(s):  
Early Intervention ◽  
Kidney Disease ◽  
Fish Oil ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Rodent Models ◽  
Polycystic Kidney

scholarly journals Dietary Soy Protein Effects on Inherited Polycystic Kidney Disease Are Influenced by Gender and Protein Level

1999 ◽  
Vol 10 (2) ◽  
pp. 300-308
Author(s):  
HAROLD M. AUKEMA ◽  
IHSAN HOUSINI ◽  
JEAN M. RAWLING
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Dietary Protein ◽  
Protein Source ◽  
Polycystic Kidney ◽  
Kidney Size ◽  
Low Protein ◽  
Protein Reduction ◽  
Protein Diets

Abstract. The effects of dietary soy protein compared to casein were examined in male and female CD1-pcy/pcy (pcy) mice with polycystic kidney disease. Animals 10 wk of age were fed purified diets containing either soy protein isolate or casein given at a level of 17.4 or 6% protein. After 13 wk on the diets, body weights and serum concentrations of albumin and protein indicated that protein nutrition was adequate on all diets. Overall, animals fed soy protein versus casein had 28% lower (P = 0.0037) relative kidney weights (g/100 g body wt), 37% lower (P = 0.0089) cyst scores (% cyst area × relative kidney weight), and 25% less (P = 0.0144) kidney water (g). Dietary protein reduction resulted in 30% lower (P = 0.0010) relative kidney weights, 25% lower (P = 0.0327) cyst scores, and 35% less (P = 0.0001) kidney water. Analysis of interactions between main effects revealed that the effects of soy protein on kidney size were significant only in females, and that effects of soy protein on cyst score were significant only in animals on the low protein diets. In addition, differences in kidney weights and cyst score due to protein reduction were significant in animals fed soy protein, but not in those fed casein as the protein source. These results show that both dietary protein source and level significantly affect polycystic kidney disease in pcy animals, with the effects of dietary soy protein being most pronounced in female animals fed the low protein diets and the effects of protein reduction being most pronounced in animals fed soy protein-based diets.

Dietary flax oil reduces renal injury, oxidized LDL content, and tissue n−6/n−3 FA ratio in experimental polycystic kidney disease

Lipids ◽  
2002 ◽  
Vol 37 (11) ◽  
pp. 1059-1065 ◽  
Author(s):  
Malcolm R. Ogborn ◽  
Evan Nitschmann ◽  
Neda Bankovic-Calic ◽  
Hope A. Weiler ◽  
Harold Aukema
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Renal Injury ◽  
Oxidized Ldl ◽  
Polycystic Kidney ◽  
Flax Oil

Dietary Soy Protein Selectively Reduces Renal Prostanoids and Cyclooxygenases in Polycystic Kidney Disease

2009 ◽  
Vol 234 (7) ◽  
pp. 737-743 ◽  
Author(s):  
Claudia Yu-Chen Peng ◽  
Deepa Sankaran ◽  
Malcolm R. Ogborn ◽  
Harold M. Aukema
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Polycystic Kidney

scholarly journals Modification of polycystic kidney disease and fatty acid status by soy protein diet

2000 ◽  
Vol 57 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Malcolm R. Ogborn ◽  
Evan Nitschmann ◽  
Hope A. Weiler ◽  
Neda Bankovic-Calic
Keyword(s):  
Fatty Acid ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Protein Diet ◽  
Fatty Acid Status ◽  
Polycystic Kidney ◽  
Acid Status
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