Distinct effects of dietary flax compared to fish oil, soy protein compared to casein, and sex on the renal oxylipin profile in models of polycystic kidney disease

2017 ◽  
Vol 123 ◽  
pp. 1-13 ◽  
Author(s):  
Jessay G. Devassy ◽  
Tamio Yamaguchi ◽  
Md Monirujjaman ◽  
Melissa Gabbs ◽  
Amir Ravandi ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Fish Oil ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Polycystic Kidney

scholarly journals Lack of Benefit of Early Intervention with Dietary Flax and Fish Oil and Soy Protein in Orthologous Rodent Models of Human Hereditary Polycystic Kidney Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155790 ◽  
Author(s):  
Tamio Yamaguchi ◽  
Jessay G. Devassy ◽  
Md Monirujjaman ◽  
Melissa Gabbs ◽  
Harold M. Aukema
Keyword(s):  
Early Intervention ◽  
Kidney Disease ◽  
Fish Oil ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Rodent Models ◽  
Polycystic Kidney

scholarly journals Dietary Soy Protein Effects on Inherited Polycystic Kidney Disease Are Influenced by Gender and Protein Level

1999 ◽  
Vol 10 (2) ◽  
pp. 300-308
Author(s):  
HAROLD M. AUKEMA ◽  
IHSAN HOUSINI ◽  
JEAN M. RAWLING
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Dietary Protein ◽  
Protein Source ◽  
Polycystic Kidney ◽  
Kidney Size ◽  
Low Protein ◽  
Protein Reduction ◽  
Protein Diets

Abstract. The effects of dietary soy protein compared to casein were examined in male and female CD1-pcy/pcy (pcy) mice with polycystic kidney disease. Animals 10 wk of age were fed purified diets containing either soy protein isolate or casein given at a level of 17.4 or 6% protein. After 13 wk on the diets, body weights and serum concentrations of albumin and protein indicated that protein nutrition was adequate on all diets. Overall, animals fed soy protein versus casein had 28% lower (P = 0.0037) relative kidney weights (g/100 g body wt), 37% lower (P = 0.0089) cyst scores (% cyst area × relative kidney weight), and 25% less (P = 0.0144) kidney water (g). Dietary protein reduction resulted in 30% lower (P = 0.0010) relative kidney weights, 25% lower (P = 0.0327) cyst scores, and 35% less (P = 0.0001) kidney water. Analysis of interactions between main effects revealed that the effects of soy protein on kidney size were significant only in females, and that effects of soy protein on cyst score were significant only in animals on the low protein diets. In addition, differences in kidney weights and cyst score due to protein reduction were significant in animals fed soy protein, but not in those fed casein as the protein source. These results show that both dietary protein source and level significantly affect polycystic kidney disease in pcy animals, with the effects of dietary soy protein being most pronounced in female animals fed the low protein diets and the effects of protein reduction being most pronounced in animals fed soy protein-based diets.

Dietary Soy Protein Selectively Reduces Renal Prostanoids and Cyclooxygenases in Polycystic Kidney Disease

2009 ◽  
Vol 234 (7) ◽  
pp. 737-743 ◽  
Author(s):  
Claudia Yu-Chen Peng ◽  
Deepa Sankaran ◽  
Malcolm R. Ogborn ◽  
Harold M. Aukema
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Polycystic Kidney

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

2007 ◽  
Vol 106 (4) ◽  
pp. e122-e128 ◽  
Author(s):  
Deepa Sankaran ◽  
Neda Bankovic-Calic ◽  
Leah Cahill ◽  
Claudia Yu-Chen Peng ◽  
Malcolm R Ogborn ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Dietary Intervention ◽  
Polycystic Kidney ◽  
Flax Oil

Effects of dietary fish oil on survival and renal fatty acid composition in murine polycystic kidney disease

1992 ◽  
Vol 12 (11) ◽  
pp. 1383-1392 ◽  
Author(s):  
H.M. Aukema ◽  
T Yamaguchi ◽  
H Takahashi ◽  
D.J. Philbrick ◽  
B.J. Holub
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Kidney Disease ◽  
Fish Oil ◽  
Polycystic Kidney Disease ◽  
Acid Composition ◽  
Polycystic Kidney ◽  
Dietary Fish

scholarly journals Modification of polycystic kidney disease and fatty acid status by soy protein diet

2000 ◽  
Vol 57 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Malcolm R. Ogborn ◽  
Evan Nitschmann ◽  
Hope A. Weiler ◽  
Neda Bankovic-Calic
Keyword(s):  
Fatty Acid ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Soy Protein ◽  
Protein Diet ◽  
Fatty Acid Status ◽  
Polycystic Kidney ◽  
Acid Status

Soy protein modification of rat polycystic kidney disease

1998 ◽  
Vol 274 (3) ◽  
pp. F541-F549 ◽  
Author(s):  
Malcolm R. Ogborn ◽  
Neda Bankovic-Calic ◽  
Christen Shoesmith ◽  
Richard Buist ◽  
James Peeling
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rat Model ◽  
Soy Protein ◽  
Proton Nuclear Magnetic Resonance ◽  
Renal Tubular Cell ◽  
Ammonium Excretion ◽  
Polycystic Kidney ◽  
Nmr Studies ◽  
H Nmr

We undertook a study to determine whether soy protein feeding would ameliorate renal injury in the Han:SPRD- cy rat model of polycystic kidney disease (PKD). Male offspring of Han:SPRD- cy heterozygotes received isocaloric diets based on 20% casein or 20% heat-treated soy protein at weaning ad libitum for 8 wk. Soy-fed animals demonstrated lower serum creatinine (66 vs. 125 μmol/l; P = 0.002), lower urinary ammonium excretion (0.080 vs. 0.173 mmol/kg; P= 0.01), reduced renal cysts (0.98 vs. 4.92 ml/kg body wt, P < 0.0001), renal fibrosis (0.79 vs. 1.4 ml/kg; P = 0.016), macrophage infiltration, renal tubular cell proliferation, and apoptosis. Proton nuclear magnetic resonance (1H-NMR) studies of urine demonstrated that soy diet was associated with increased losses of citric acid cycle organic anions.1H-NMR of perchloric acid-extracted tissue found that levels of succinate were not depleted in soy-fed animals, despite increased urinary losses. Soy-fed animals had marked elevation of tissue betaine ( P < 0.001), with reduced taurine and cholines, compared with casein-fed animals ( P < 0.001). Soy feeding dramatically reduces both tubular and interstitial pathology in the Han:SPRD- cy rat model of PKD, through mechanisms that remain to be determined.

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