Plasma Homocysteine Is Elevated in Elderly Patients with Memory Complaints and Vascular Disease

2007 ◽  
Vol 23 (5) ◽  
pp. 321-326 ◽  
Author(s):  
Karin Nilsson ◽  
Lars Gustafson ◽  
Björn Hultberg
Keyword(s):  
Elderly Patients ◽  
Vascular Disease ◽  
Plasma Homocysteine ◽  
Memory Complaints ◽  
With Memory

Plasma homocysteine—a marker of vascular disease in elderly patients with mental illness

2010 ◽  
Vol 43 (13-14) ◽  
pp. 1056-1059 ◽  
Author(s):  
Karin Nilsson ◽  
Lars Gustafson ◽  
Björn Hultberg
Keyword(s):  
Mental Illness ◽  
Elderly Patients ◽  
Vascular Disease ◽  
Plasma Homocysteine

Role of Inflammatory Markers in Elderly Type 2 Diabetic Patients with Mild Cognitive Impairment

2019 ◽  
Vol 15 (3) ◽  
pp. 247-253 ◽  
Author(s):  
Salwa S. Hosny ◽  
Ahmed M. Bahaaeldin ◽  
Mohamed S. Khater ◽  
Meram M. Bekhet ◽  
Hayam A. Hebah ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Elderly Patients ◽  
Vascular Disease ◽  
Plasma Glucose ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Hs Crp ◽  
And Control

<P>Background: Type 2 diabetes (T2DM) is a risk factor for Alzheimer’s disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. </P><P> Objectives: To determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI). Methods: Our study was conducted on 90 elderly subjects (aged 60 years old or more). They were divided into Group І, 30 patients with T2DM and mild cognitive impairment, group ІІ, 30 patients with T2DM without cognitive impairment and group III, 30 healthy subjects as a control group. They were subjected to history taking, full clinical examination, anthropometric measurement, the Addenbrooke’s Cognitive Examination III (ACE---III 2012), Fasting plasma glucose, 2 hours plasma glucose, HbA1c, lipid profile, protein/creatinine ratio, serum sVCAM-1 and hs-CRP. Results: Serum levels of sVCAM-1 in diabetic elderly patients with MCI were significantly higher (946.7 ± 162.01 ng/ml) than diabetic elderly patients without cognitive impairment (479.06 ± 65.27 ng/ml) and control (263.7 ± 72.05 ng/ml) with (P=0.002). Serum levels of Hs-CRP in diabetic elderly patients with MCI were significantly higher than as diabetic elderly patients without cognitive impairment and control with (P=0.005). Conclusion: Elderly diabetic patients with mild cognitive impairment have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation than other groups.</P>

Amyloid-PET Positive Patient with bvFTD: Wrong Diagnosis, False Positive Scan, or Co-pathology?

2021 ◽  
pp. 10.1212/CPJ.0000000000001049
Author(s):  
Tobias Langheinrich ◽  
Christopher Kobylecki ◽  
Matthew Jones ◽  
Jennifer C Thompson ◽  
Julie S Snowden ◽  
...  
Keyword(s):  
Preventive Treatment ◽  
Amyloid Pet ◽  
Set Shifting ◽  
Memory Clinic ◽  
Memory Complaints ◽  
Positive Scan ◽  
Wrong Diagnosis ◽  
Ε4 Allele ◽  
Cortical Regions ◽  
With Memory

A 65-year-old man was referred to a local memory clinic with memory complaints but clinical assessment found no abnormalities. When he presented two years later to our clinic social disinhibition, reduced empathy, poor judgment and hoarding had become obvious. He showed no insight. He had ischemic heart disease and was on preventive treatment. His mother died aged 97 suffering from dementia. Neurological examination was normal. During neuropsychological examination he exhibited verbal and behavioral disinhibition, inattention, emotional blunting and unconcern. He had prominent difficulties in abstraction, set shifting and sequencing with significant impact on memory tests (table1). A clinical diagnosis of behavioral variant FTD (bvFTD) was made. MRI (figure A) showed right more than left-sided temporal atrophy, bilateral frontal and milder parietal atrophy. Fluorodeoxyglucose (FDG)-PET (figure B) demonstrated fronto-temporal hypometabolism. Metabolism in the posterior cingulate was normal. He was homozygous for the APOE ε4 allele and negative for the C9orf72 expansion and mutations in MAPT, GRN, PSEN1, and APP. [18F]-Florbetapir PET (figure C) revealed increased tracer binding in all cortical regions corresponding to a centiloid value of 74%.

Effects of virtual reality exergame on psychophysiological and postural disorders in elderly patients

2021 ◽  
Author(s):  
AE Khizhnikova ◽  
AS Klochkov ◽  
AA Fuks ◽  
AM Kotov-Smolenskiy ◽  
NA Suponeva ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Elderly Patients ◽  
Vascular Disease ◽  
Balance Control ◽  
Balance Training ◽  
Medical Problem ◽  
Rehabilitation Program ◽  
Advanced Age ◽  
Balance Impairment ◽  
Underlying Causes

Balance impairment at advanced age is a serious medical problem that often has significant implications and affects the quality of the patient’s life. Among the underlying causes are overall slowness of motor response and vestibular syndrome. Virtual reality exergames, including reaction and balance training, hold promise for managing balance dysfunction. The aim of this study was to investigate the effects of a combination rehabilitation program containing elements of virtual reality exergame on the postural and psychophysiological parameters of elderly patients with small vascular disease The study was conducted in 24 patients with small vascular disease (median age: 66 years). All patients underwent a virtual reality rehabilitation program. Psychophysiological, postural and clinical evaluations were performed at baseline and after the program was completed. Balance function measured on the Berg scale improved significantly and was 53 [52; 55] after the training program vs 50 [45; 54] at baseline (p < 0.05). The strategy of balance control also changed: the Romberg ratio was 266 [199.5; 478.5] before rehabilitation and 221 [149.25; 404] after the program was completed (p < 0.05). The most pronounced changes in the measured psychophysiological parameters occurred in the simple audiomotor reaction, which improved from 210 [174.25; 245.5] at baseline to 180.5 [170.5; 208] after rehabilitation (p < 0.05). Thus, the combination balance and reaction virtual reality training is an effective rehabilitation method for advanced-age patients with balance impairment.

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