scholarly journals Elevated Plasma Homocysteine Level in Vascular Dementia Reflects the Vascular Disease Process

2013 ◽  
Vol 3 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Karin Nilsson ◽  
Lars Gustafson ◽  
Björn Hultberg
Keyword(s):  
Vascular Dementia ◽  
Vascular Disease ◽  
Homocysteine Level ◽  
Disease Process ◽  
Plasma Homocysteine ◽  
Elevated Plasma ◽  
Plasma Homocysteine Level

scholarly journals Elevated Plasma Homocysteine Level in Patients With Parkinson Disease

2004 ◽  
Vol 61 (6) ◽  
pp. 865 ◽  
Author(s):  
Padraig E. O'Suilleabhain ◽  
Victor Sung ◽  
Carlos Hernandez ◽  
Laura Lacritz ◽  
Richard B. Dewey Jr ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Elevated Plasma ◽  
Plasma Homocysteine Level

Elevated plasma homocysteine level is associated with ischemic stroke in Chinese hypertensive patients

2014 ◽  
Vol 25 (6) ◽  
pp. 538-544 ◽  
Author(s):  
Chang-yi Wang ◽  
Zhong-wei Chen ◽  
Tao Zhang ◽  
Jun Liu ◽  
Si-han Chen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Elevated Plasma ◽  
Plasma Homocysteine Level ◽  
Hypertensive Patients

scholarly journals Methylation demand: a key determinant of homocysteine metabolism.

2004 ◽  
Vol 51 (2) ◽  
pp. 405-413 ◽  
Author(s):  
John T Brosnan ◽  
Rene L Jacobs ◽  
Lori M Stead ◽  
Margaret E Brosnan
Keyword(s):  
Pyridoxal Phosphate ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Methionine Synthase ◽  
Elevated Plasma ◽  
Plasma Homocysteine Level ◽  
Vitamin Status ◽  
The Many ◽  
B Vitamin ◽  
Quantitative Importance

Elevated plasma homocysteine is a risk factor for cardiovascular disease and Alzheimer's disease. To understand the factors that determine the plasma homocysteine level it is necessary to appreciate the processes that produce homocysteine and those that remove it. Homocysteine is produced as a result of methylation reactions. Of the many methyltransferases, two are, normally, of the greatest quantitative importance. These are guanidinoacetate methyltransferase (that produces creatine) and phosphatidylethanolamine N-methyltransferase (that produces phosphatidylcholine). In addition, methylation of DOPA in patients with Parkinson's disease leads to increased homocysteine production. Homocysteine is removed either by its irreversible conversion to cysteine (transsulfuration) or by remethylation to methionine. There are two separate remethylation reactions, catalyzed by betaine:homocysteine methyltransferase and methionine synthase, respectively. The reactions that remove homocysteine are very sensitive to B vitamin status as both the transsulfuration enzymes contain pyridoxal phosphate, while methionine synthase contains cobalamin and receives its methyl group from the folic acid one-carbon pool. There are also important genetic influences on homocysteine metabolism.

Elevated plasma homocysteine level in slow coronary flow

2005 ◽  
Vol 101 (1) ◽  
pp. 143-145 ◽  
Author(s):  
Irfan Barutcu ◽  
Alpay Turan Sezgin ◽  
Nurzen Sezgin ◽  
Hakan Gullu ◽  
Ali Metin Esen ◽  
...  
Keyword(s):  
Coronary Flow ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Elevated Plasma ◽  
Plasma Homocysteine Level ◽  
Slow Coronary Flow

scholarly journals Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents

2009 ◽  
Vol 12 (1) ◽  
pp. 52-53
Author(s):  
Zh V Shutskaya ◽  
E B Bashnina ◽  
O V Mochkin ◽  
T A Dubinina ◽  
T Yu Tryasova
Keyword(s):  
Risk Factor ◽  
Hba1c Level ◽  
Independent Risk Factor ◽  
Homocysteine Level ◽  
Study Groups ◽  
Plasma Homocysteine ◽  
Elevated Plasma ◽  
Control Groups ◽  
Plasma Homocysteine Level ◽  
And Control

Aim. To consider homocysteinemia in children and adolescents with diabetes mellitus (DM1) as an independent risk factor of diabetic nephro- and retinopathy (DN and DR). Materials and methods. Twenty nine adolescents (19 girls and 10 boys) with DM1 were examined. DN and DR were diagnosed in conformity with medical aid standards for DM1patients. Plasma homocysteine level was measured by IEA. Results. Plasma homocysteine level in DN patients was higher (6.4?1.6, n=10) than in DR group (5.3?1.7, n=9) and controls (5.6?1.8, n=10). Patients of all study groups werecomparable in terms of age, DM duration, and HbA1c level. Conclusion. Plasma homocysteine level in DN patients was higher than in DR and control groups. It gives reason to consider this parameter as an independent risk factor alongwith some others in pathogenesis of diabetic microangiopathies (in the first place, nephropathy). Adolescents with DM1 and elevated plasma homocysteine level need additionalcorrection by specific medicines.

Sign in / Sign up

Export Citation Format

Share Document