The Hemodynamically Significant Ductus Arteriosus in Critically Ill Full-Term Neonates

Neonatology ◽  
2006 ◽  
Vol 91 (4) ◽  
pp. 260-265 ◽  
Author(s):  
Linh G. Ly ◽  
Judith Hawes ◽  
Hilary E. Whyte ◽  
Lilian S. Teixeira ◽  
Patrick J. McNamara
Keyword(s):  
Critically Ill ◽  
Ductus Arteriosus ◽  
Full Term ◽  
Term Neonates

scholarly journals Time to spontaneous ductus arteriosus closure in full-term neonates

Open Heart ◽  
2016 ◽  
Vol 3 (1) ◽  
pp. e000413 ◽  
Author(s):  
Hiroyuki Nagasawa ◽  
Chikuma Hamada ◽  
Masashi Wakabayashi ◽  
Yuki Nakagawa ◽  
Satoshi Nomura ◽  
...  
Keyword(s):  
Ductus Arteriosus ◽  
Full Term ◽  
Term Neonates

Blood pressure in non-critically ill preterm and full-term neonates

2007 ◽  
Vol 22 (2) ◽  
pp. 249-257 ◽  
Author(s):  
Bijana Pejovic ◽  
Amira Peco-Antic ◽  
Jelena Marinkovic-Eric
Keyword(s):  
Blood Pressure ◽  
Critically Ill ◽  
Full Term ◽  
Term Neonates

scholarly journals High-Dose Oral Ibuprofen in Treatment of Patent Ductus Arteriosus in Full-Term Neonates

2015 ◽  
Vol 25 (4) ◽  
Author(s):  
Shahnaz Pourarian ◽  
Mehrdad Rezaie ◽  
Hamid Amoozgar ◽  
Ali-Mohammad Shakiba ◽  
Mohammad-Reza Edraki ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Full Term ◽  
High Dose ◽  
Term Neonates ◽  
Dose Oral ◽  
Oral Ibuprofen ◽  
Patent Ductus

scholarly journals The Effects of Oral Ibuprofen on Medicinal Closure of Patent Ductus Arteriosus in Full-Term Neonates in the Second Postnatal Week

2016 ◽  
Vol 26 (4) ◽  
Author(s):  
Mohammad Reza Alipour ◽  
Mansooreh Mozaffari Shamsi ◽  
Seyedeh Mahdieh Namayandeh ◽  
Zohreh Pezeshkpour ◽  
Fatemeh Rezaeipour ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Full Term ◽  
Term Neonates ◽  
Oral Ibuprofen ◽  
Patent Ductus

Assessment of serum levels of vitamin B12 in full term neonates with indirect hyperbilirubinemia

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Gamal Mohamed ◽  
Reem Abdel-Salam ◽  
Rabie Mortada
Keyword(s):  
Vitamin B12 ◽  
Serum Levels ◽  
Full Term ◽  
Term Neonates

Cord Blood Alkaline Phosphatase as a predictor of Neonatal Jaundice in full term neonates

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Samah Esmail ◽  
Ali Abdo ◽  
Sherief Elgebaly ◽  
Marwa Mostafa
Keyword(s):  
Alkaline Phosphatase ◽  
Cord Blood ◽  
Neonatal Jaundice ◽  
Full Term ◽  
Term Neonates

scholarly journals Sufentanil Disposition and Pharmacokinetic Model-Based Dosage Regimen for Sufentanil in Ventilated Full-Term Neonates

Pharmacology ◽  
2021 ◽  
pp. 1-6
Author(s):  
Pavla Pokorná ◽  
Martin Šíma ◽  
Birgit Koch ◽  
Dick Tibboel ◽  
Ondřej Slanař
Keyword(s):  
Linear Regression ◽  
Dosage Regimen ◽  
Regression Models ◽  
Drug Disposition ◽  
Prospective Trial ◽  
Full Term ◽  
Pharmacokinetic Parameters ◽  
Therapeutic Drug ◽  
Linear Regression Models ◽  
Term Neonates

<b><i>Introduction:</i></b> Sufentanil is a potent synthetic opioid used for analgesia in neonates; however, data concerning drug disposition of sufentanil and dosage regimen are sparse in this population. Therefore, the aim of the study was to explore sufentanil disposition and to propose optimal loading and maintenance doses of sufentanil in ventilated full-term neonates. <b><i>Methods:</i></b> Individual sufentanil pharmacokinetic parameters were calculated based on therapeutic drug monitoring data using a 2-compartmental model. Linear regression models were used to explore the covariates. <b><i>Results:</i></b> The median (IQR) central volume of distribution (Vd<sub>c</sub>) and clearance (CL) for sufentanil were 4.7 (4.1–5.4) L/kg and 0.651 (0.433–0.751) L/h/kg, respectively. Linear regression models showed relationship between Vd<sub>c</sub> (L) and GA (<i>r</i><sup>2</sup> = 0.3436; <i>p</i> = 0.0452) as well as BW (<i>r</i><sup>2</sup> = 0.4019; <i>p</i> = 0.0268). Median optimal sufentanil LD and MD were 2.13 (95% CI: 1.78–2.48) μg/kg and 0.29 (95% CI: 0.22–0.37) μg/kg/h, respectively. Median daily COMFORT-B (IQR) scores ranged from 6 to 23 while no significant relationship between pharmacokinetic parameters and COMFORT-B scores was found. <b><i>Discussion/Conclusion:</i></b> Body weight and gestational age were found as weak covariates for sufentanil distribution, and the dosage regimen was developed for a prospective trial.

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