scholarly journals The Effects of Oral Ibuprofen on Medicinal Closure of Patent Ductus Arteriosus in Full-Term Neonates in the Second Postnatal Week

2016 ◽  
Vol 26 (4) ◽  
Author(s):  
Mohammad Reza Alipour ◽  
Mansooreh Mozaffari Shamsi ◽  
Seyedeh Mahdieh Namayandeh ◽  
Zohreh Pezeshkpour ◽  
Fatemeh Rezaeipour ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Full Term ◽  
Term Neonates ◽  
Oral Ibuprofen ◽  
Patent Ductus

scholarly journals High-Dose Oral Ibuprofen in Treatment of Patent Ductus Arteriosus in Full-Term Neonates

2015 ◽  
Vol 25 (4) ◽  
Author(s):  
Shahnaz Pourarian ◽  
Mehrdad Rezaie ◽  
Hamid Amoozgar ◽  
Ali-Mohammad Shakiba ◽  
Mohammad-Reza Edraki ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Full Term ◽  
High Dose ◽  
Term Neonates ◽  
Dose Oral ◽  
Oral Ibuprofen ◽  
Patent Ductus

Effectiveness of Dual Medication Therapy (Oral Acetaminophen and Oral Ibuprofen) for the Management of Patent Ductus Arteriosus in Extremely Premature Infants: A Feasibility Trial

2021 ◽  
Author(s):  
Sanket D. Shah ◽  
Kartikeya Makker ◽  
Padma Nandula ◽  
Carmen Smotherman ◽  
Andrea Kropf ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Left Pulmonary Artery ◽  
Mean Difference ◽  
Feasibility Trial ◽  
P Value ◽  
Concomitant Treatment ◽  
Medication Therapy ◽  
Oral Ibuprofen ◽  
Patent Ductus

Objective The study aimed to evaluate the efficacy of dual medication therapy (DMT) with oral acetaminophen and oral ibuprofen for the closure of a hemodynamically significant patent ductus arteriosus (hsPDA). Study Design In a prospective case–control cohort study (July 2017–May 2019), infants <29 weeks' gestational age and birth weight <1,000 g at ≤14 postnatal days with hsPDA and ratio of the smallest ductal diameter to the ostium of the left pulmonary artery diameter >0.5 were eligible. Infants received 10 mg/kg oral ibuprofen followed by two additional doses of 5 mg/kg at 24 and 48 hours after the initial ibuprofen dose and concomitant treatment with 15 mg/kg oral acetaminophen every 6 hours for 3 days (12 doses). Success of PDA treatment was defined as a small or absent PDA as ascertained by echocardiographic measurements. The p-values of comparisons were adjusted for multiple comparisons to preserve an error rate of 5%. Results Overall, 20 infants received oral DMT and 11 infants received intravenous single medication therapy (SMT) with ibuprofen. The rates of successful PDA treatment following the first treatment in DMT and SMT groups were not statistically different (11/20 [55%] vs. 4/11 [36%], p = 0.46). However, DMT significantly decreased PDA size (mean difference = 0.54 mm, 95% confidence interval [CI]: 0.21–0.96, adjusted p-value = 0.0002) and PDA/LPA ratio (mean difference = 0.27, 95% CI: 0.10–0.47, adjusted p-value = 0.0004). We observed no evidence of hematologic, hepatic, or renal impairment. Conclusion DMT achieved a greater degree of PDA closure than SMT and did not result in abnormalities in hepatic and renal profile. Key Points

Patent ductus arteriosus in micropreemies and full-term infants: The relative merits of surgical ligation versus indomethacin treatment

2003 ◽  
Vol 38 (3) ◽  
pp. 492-496 ◽  
Author(s):  
Danny C. Little ◽  
Theodore C. Pratt ◽  
Shannon E. Blalock ◽  
Donald R. Krauss ◽  
Donald R. Cooney ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Full Term ◽  
Term Infants ◽  
Surgical Ligation ◽  
Patent Ductus ◽  
Indomethacin Treatment
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