Acylated Ghrelin Secretion Is Acutely Suppressed by Oral Glucose Load or Insulin-Induced Hypoglycemia Independently of Basal Growth Hormone Secretion in Humans

2006 ◽  
Vol 67 (5) ◽  
pp. 211-219 ◽  
Author(s):  
Sang Wan Kim ◽  
Kyung Won Kim ◽  
Chan Soo Shin ◽  
Do Joon Park ◽  
Kyong Soo Park ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Oral Glucose ◽  
Acylated Ghrelin ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Ghrelin Secretion

Growth hormone nadir during oral glucose load depends on waist circumference, gender and age: normative data in 231 healthy subjects

2011 ◽  
Vol 74 (2) ◽  
pp. 234-240 ◽  
Author(s):  
Annamaria Colao ◽  
Rosario Pivonello ◽  
Renata S. Auriemma ◽  
Ludovica F. S. Grasso ◽  
Mariano Galdiero ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Waist Circumference ◽  
Healthy Subjects ◽  
Normative Data ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Gender And Age

Human Growth Hormone Secretion after Exercise and Oral Glucose Administration in Patients with Short Stature

1972 ◽  
Vol 34 (6) ◽  
pp. 1055-1058 ◽  
Author(s):  
YOSHIAKI OKADA ◽  
TORU HIKITA ◽  
KAZUYUKI ISHITOBI ◽  
MASAYOSHI WADA ◽  
YASUNOBU SANTO ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Human Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Human Growth ◽  
Oral Glucose ◽  
Glucose Administration

Plasma ghrelin response to an oral glucose load in growth hormone-deficient adults treated with growth hormone

2007 ◽  
Vol 119 (3-4) ◽  
pp. 99-103 ◽  
Author(s):  
Peter Pusztai ◽  
Judit Toke ◽  
Aniko Somogyi ◽  
Eva Ruzicska ◽  
Beatrix Sarman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

Effects of glucose load and/or arginine on insulin and growth hormone secretion in hyperprolactinemia and obesity

1996 ◽  
Vol 135 (2) ◽  
pp. 205-210 ◽  
Author(s):  
Mauro Maccario ◽  
Silvia Grottoli ◽  
Paola Razzore ◽  
Massimo Procopio ◽  
Salvatore Endrio Oleandri ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Growth Hormone ◽  
Insulin Secretion ◽  
Body Mass ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Insulin Response ◽  
Glucose Load ◽  
Gh Secretion ◽  
Glucose Levels

Maccario M, Grottoli S, Razzore P, Procopio M, Oleandri SE, Ciccarelli E, Camanni F, Ghigo E. Effects of glucose load and/or arginine on insulin and growth hormone secretion in hyperprolactinemia and obesity. Eur J Endocrinol 1996;135:205–10. ISSN 0804–4643 In hyperprolactinemic patients an exaggerated glucose-induced insulin secretion has been reported, but these results have not been confirmed by other researchers. On the other hand, there are few data concerning somatotrope secretion in this condition. In order to clarify these points, in seven normal weight hyperprolactinemic female patients (HP: age 18–46 years, body mass index = 21.8 ± 0.6 kg/m2, basal prolactin = 91.7 ± 16.5 μg/l) we studied the effects of glucose load (100 g orally) and/or arginine (0.5 g/kg infused over 30 min on insulin glucose and growth hormone (GH) levels. These results were compared with those obtained in seven patients with simple obesity (OB: age 23–48 years, body mass index = 38.3 ± 2.6 kg/m2) in whom exaggerated insulin and low GH secretion are well known. Seven normal women (NS: age 26–32 years, body mass index = 20.6 ± 1.9 kg/m2) were studied as controls. The insulin response to glucose in HP (area under curve = 11460.8 ± 1407.5 mU·min·1−1) was not significantly different from NS (7743.7 ±882.9 mU·min·1−1) and OB (14 504.8 ± 1659.9 mU·min·1−1). The arginine-induced insulin release in HP and OB was similar (4219.4 ± 631.7 and 4107.3 ± 643.2 mU·min·1−1. respectively), both being higher (p < 0.02) than in NS (2178.1 ± 290.9 mU·min·1−1). Glucose and arginine had an additive effect on insulin release in HP and NS (19 769.1 ± 3249.6 and 10996.6 ± 1201.0 mU·min·1−1, respectively) and a synergistic effect in OB (28117.3± 5224.7 mU·min·1−1). In HP the insulin response to the combined administration of glucose and arginine was not significantly different from the one in OB, and both were higher (p < 0.05) than in NS. The increase in glucose levels after glucose administered on its own or combined with arginine was higher (p < 0.02) and longer lasting in OB than in NS and HP. After arginine in OB, the glucose levels did not show the late decrease under baseline values observed in HP and NS. Glucose inhibited GH secretion both in HP and NS (p < 0.05), while arginine stimulated it in all groups, although the GH response in HP and NS was higher (p < 0.03) than in OB. The arginine-induced GH secretion was inhibited by glucose in HP and NS but not in OB. These results demonstrate that both in hyperprolactinemic patients and in obesity there is a clear increase in insulin secretion. The insulin hyperresponsiveness in hyperprolactinemia is more clearly demonstrated by combined stimulation with glucose and arginine. In spite of similar insulin hypersecretion in hyperprolactinemic and obese patients, GH secretion is reduced only in the latter; with these data the hypothesis that somatotrope insufficiency in obesity is due to hyperinsulinism is unlikely. Ezio Ghigo, Divisione di Endocrinologia, Ospedale Molinette, C.so Dogliotti 14, 10126 Torino, Italy

scholarly journals Growth hormone response to oral glucose load in untreated diabetic children.

1971 ◽  
Vol 46 (245) ◽  
pp. 117-119 ◽  
Author(s):  
C G Theodoridis ◽  
G W Chance ◽  
B T Rudd ◽  
G A Brown
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Response ◽  
Oral Glucose ◽  
Hormone Response ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Diabetic Children
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