scholarly journals The Effect of Growth Hormone on the Response of Total and Acylated Ghrelin to a Standardized Oral Glucose Load and Insulin Resistance in Children with Prader-Willi Syndrome

2007 ◽  
Vol 92 (3) ◽  
pp. 834-840 ◽  
Author(s):  
Berthold P. Hauffa ◽  
Katja Haase ◽  
Ina M. Range ◽  
Nicole Unger ◽  
Klaus Mann ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Growth Hormone ◽  
Oral Glucose ◽  
Prader Willi Syndrome ◽  
Acylated Ghrelin ◽  
Oral Glucose Load ◽  
Glucose Load

Growth hormone nadir during oral glucose load depends on waist circumference, gender and age: normative data in 231 healthy subjects

2011 ◽  
Vol 74 (2) ◽  
pp. 234-240 ◽  
Author(s):  
Annamaria Colao ◽  
Rosario Pivonello ◽  
Renata S. Auriemma ◽  
Ludovica F. S. Grasso ◽  
Mariano Galdiero ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Waist Circumference ◽  
Healthy Subjects ◽  
Normative Data ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Gender And Age

Plasma ghrelin response to an oral glucose load in growth hormone-deficient adults treated with growth hormone

2007 ◽  
Vol 119 (3-4) ◽  
pp. 99-103 ◽  
Author(s):  
Peter Pusztai ◽  
Judit Toke ◽  
Aniko Somogyi ◽  
Eva Ruzicska ◽  
Beatrix Sarman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

scholarly journals Growth hormone response to oral glucose load in untreated diabetic children.

1971 ◽  
Vol 46 (245) ◽  
pp. 117-119 ◽  
Author(s):  
C G Theodoridis ◽  
G W Chance ◽  
B T Rudd ◽  
G A Brown
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Response ◽  
Oral Glucose ◽  
Hormone Response ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Diabetic Children

scholarly journals Effect of insulin resistance on whole blood mRNA and microRNA expression affecting bone turnover

2019 ◽  
Vol 181 (5) ◽  
pp. 525-537 ◽  
Author(s):  
Urszula Razny ◽  
Anna Polus ◽  
Joanna Goralska ◽  
Anna Zdzienicka ◽  
Anna Gruca ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Whole Blood ◽  
Wnt Signalling ◽  
Control Group ◽  
Oral Glucose ◽  
Sensitivity Index ◽  
Bone Homeostasis ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Obese Subjects

Objective To evaluate the effect of insulin resistance in obesity on the expression in whole blood of mRNA and miRNA affecting bone homeostasis as well as to estimate the influence of oral glucose load (OGTT) on serum osteocalcin concentration in obese individuals with and without insulin resistance. Design Cross-sectional study. Methods Carboxylated (cOC), undercarboxylated (ucOC) and total osteocalcin were measured by ELISA in the serum of obese subjects with insulin resistance (n = 41) and obese subjects without insulin resistance (n = 41) (control group) during OGTT. Analysis of gene expression (microarray) and miRNAs (real-time PCR) was performed in venous blood (representating samples) collected before OGTT from obese with insulin resistance and controls. Results Obese subjects with insulin resistance (higher HOMA-IR and lower oral glucose insulin sensitivity index) presented significantly increased expression of WNT signalling inhibitors (DKK1, DKK2, SOST, SFRP1) and downregulation of the key factor in WNT signalling – β catenin participating in osteoblasts differentiation. Expression of miRNA involved in osteoblastogenesis was also inhibited (miR-29b, miR-181a, miR-210, miR-324-3p). During OGTT, contrary to the control group, subjects with insulin resistance presented suppression of cOC and total OC decrease after 1 and 2 h of oral glucose load. Conclusions Obese subjects with insulin resistance may have defects in osteoblastogenesis that was demonstrated via key signalling molecules mRNA downregulation, and increased expression of WNT antagonists as well as inhibition of expression of miRNA participating in the regulation of osteoblast differentiation. Disturbed osteoblastogenesis in insulin-resistant subjects results in the suppression of blood carboxylated and total osteocalcin decrease during OGTT.

Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance

1999 ◽  
Vol 77 (10) ◽  
pp. 749-754 ◽  
Author(s):  
C V Anuradha ◽  
S D Balakrishnan
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Renal Function ◽  
Glucose Tolerance ◽  
Plasma Levels ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Blood Pressure Elevation ◽  
Glucose Levels

Fructose feeding induces moderate increases in blood pressure levels in normal rats, which is associated with hyperinsulinemia, insulin resistance, and impaired glucose tolerance. Increased vascular resistance, sodium retention, and sympathetic overactivity have been proposed to contribute to the blood pressure elevation in this model. Taurine, a sulphur-containing amino acid, has been reported to have antihypertensive and sympatholytic actions. In the present study, the effects of taurine on blood pressure, plasma levels of glucose and insulin, glucose tolerance, and renal function were studied in fructose-fed rats. Fructose-fed rats had higher blood pressure and elevated plasma levels of insulin and glucose. The plasma glucose levels were higher in fructose-fed rats than in controls at 15, 30, and 60 min after the oral glucose load. Treatment with 2% taurine in drinking water prevented the blood pressure elevation and attenuated the hyperinsulinemia in fructose-fed rats. The exaggerated glucose levels in response to the oral glucose load was also prevented by taurine administration. Thus, taurine supplementation could be beneficial in circumventing metabolic alterations in insulin resistance.Key words: fructose feeding, hypertension, hyperinsulinemia, renal function, taurine.

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