Significance of Cancer Involvement at the Ureteral Margin Detected on Routine Frozen Section Analysis during Radical Cystectomy

2006 ◽  
Vol 77 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Sang Eun Lee ◽  
Seok-Soo Byun ◽  
Sung Kyu Hong ◽  
In Ho Chang ◽  
Yong June Kim ◽  
...  
Keyword(s):  
Radical Cystectomy ◽  
Frozen Section ◽  
Frozen Section Analysis ◽  
Section Analysis

scholarly journals Can frozen-section analysis of ureteric margins at the time of radical cystectomy predict upper tract recurrence?

2020 ◽  
Vol 18 (3) ◽  
pp. 155-162
Author(s):  
Karim Soliman ◽  
Diaa-Eldin Taha ◽  
Omar M. Aboumarzouk ◽  
Islam Osama Koraiem ◽  
Ahmed A. Shokeir
Keyword(s):  
Radical Cystectomy ◽  
Frozen Section ◽  
Upper Tract ◽  
Frozen Section Analysis ◽  
Section Analysis

scholarly journals Utility of Routine Intraoperative Ureteral Frozen Section Analysis at Radical Cystectomy: Outcomes from a Regional Australian Center

2018 ◽  
Vol 12 (2) ◽  
pp. 70-73 ◽  
Author(s):  
Joanne Tang ◽  
Weranja Ranasinghe ◽  
Janice Cheng ◽  
Sabiena Van Es ◽  
Mike Monsour ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Cox Regression ◽  
Frozen Section ◽  
Fold Increase ◽  
Tumor Stage ◽  
Clinical Staging ◽  
Cox Regression Analysis ◽  
Frozen Section Analysis ◽  
Section Analysis

Introduction: The objective of this study was to look at the usefulness and cost effectiveness of intraoperative frozen section analysis (FSA) of the ureters at the time of radical cystectomy. Methods: Pathology notes of patients undergoing radical cystectomy for primary bladder cancer between the years 2000-2015 at our institution were reviewed. Results: A total of 196 ureteric specimens from 98 patients were reviewed. Of the 98 patients, 9% (n = 9) had positive ureteric margins, of which all were ≥ T2, with 44% (4 of 9) being T = 4. In all cases of positive FSA, preoperative clinical staging was ≥ T2. In cases where cancer staging was upgraded post-cystectomy, there were no cases of positive FSA. After adjusting for tumor stage in ≥ T2a, using Cox regression analysis, positive frozen section was associated with a 4.2 fold increase in overall mortality (95%CI 1.3-13.8; p = 0.02). Cost associated with FSA was AU$1,351.90 to obtain 1 positive result. Conclusion: Patients with positive ureteric FSA are at higher risk of mortality post cystectomy, despite excision to negative tissue. However, FSA of the distal ureters at cystectomy were unlikely to be positive unless the bladder cancer stage was ≥ T2. Hence, routine ureteric FSA may not be necessary in patients undergoing cystectomy for non-muscle invasive bladder tumors.

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