Frozen Section Analysis of Ureteral Margins in Patients Undergoing Radical Cystectomy for Bladder Cancer: Differential Impact of Carcinoma in situ in the Bladder on Reliability and Impact on Tumour Recurrence in the Upper Urinary Tract

2014 ◽  
Vol 92 (1) ◽  
pp. 50-54 ◽  
Author(s):  
Andreas Loeser ◽  
Tiemo Katzenberger ◽  
Daniel C. Vergho ◽  
Arkadius Kocot ◽  
Maximilian Burger ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Tract ◽  
Radical Cystectomy ◽  
Carcinoma In Situ ◽  
Frozen Section ◽  
Upper Urinary Tract ◽  
Differential Impact ◽  
Frozen Section Analysis ◽  
Section Analysis

scholarly journals Utility of Routine Intraoperative Ureteral Frozen Section Analysis at Radical Cystectomy: Outcomes from a Regional Australian Center

2018 ◽  
Vol 12 (2) ◽  
pp. 70-73 ◽  
Author(s):  
Joanne Tang ◽  
Weranja Ranasinghe ◽  
Janice Cheng ◽  
Sabiena Van Es ◽  
Mike Monsour ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Cox Regression ◽  
Frozen Section ◽  
Fold Increase ◽  
Tumor Stage ◽  
Clinical Staging ◽  
Cox Regression Analysis ◽  
Frozen Section Analysis ◽  
Section Analysis

Introduction: The objective of this study was to look at the usefulness and cost effectiveness of intraoperative frozen section analysis (FSA) of the ureters at the time of radical cystectomy. Methods: Pathology notes of patients undergoing radical cystectomy for primary bladder cancer between the years 2000-2015 at our institution were reviewed. Results: A total of 196 ureteric specimens from 98 patients were reviewed. Of the 98 patients, 9% (n = 9) had positive ureteric margins, of which all were ≥ T2, with 44% (4 of 9) being T = 4. In all cases of positive FSA, preoperative clinical staging was ≥ T2. In cases where cancer staging was upgraded post-cystectomy, there were no cases of positive FSA. After adjusting for tumor stage in ≥ T2a, using Cox regression analysis, positive frozen section was associated with a 4.2 fold increase in overall mortality (95%CI 1.3-13.8; p = 0.02). Cost associated with FSA was AU$1,351.90 to obtain 1 positive result. Conclusion: Patients with positive ureteric FSA are at higher risk of mortality post cystectomy, despite excision to negative tissue. However, FSA of the distal ureters at cystectomy were unlikely to be positive unless the bladder cancer stage was ≥ T2. Hence, routine ureteric FSA may not be necessary in patients undergoing cystectomy for non-muscle invasive bladder tumors.

scholarly journals The Efficacy of Intraoperative Frozen Section Analysis during Breast-Conserving Surgery for Patients with Ductal Carcinoma in Situ

2016 ◽  
Vol 10 ◽  
pp. BCBCR.S40868 ◽  
Author(s):  
Mi Jin Kim ◽  
Cheol Seung Kim ◽  
Young Sam Park ◽  
Eun Hye Choi ◽  
Kyu Dam Han
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Frozen Section ◽  
Breast Conserving Surgery ◽  
Resection Margins ◽  
Intraoperative Frozen Section ◽  
Frozen Section Analysis ◽  
Section Analysis

Introduction Recently, the incidence of ductal carcinoma in situ (DCIS), a noninvasive breast malignancy, has increased. This has resulted in an increase in the incidence of breast-conserving surgery (BCS). Numerous studies have suggested that intraoperative frozen section analysis (IFSA) could reduce the rate of additional excisions required to obtain adequate resection margins. However, DCIS is a known risk factor for positive margin status during BCS. Furthermore, some authors have concluded that IFSA may not be reliable for the detection of DCIS. Aim The aim of this study was to evaluate the safety and efficacy of IFSA in patients with DCIS. Methods The operative and pathological reports of patients with DCIS, who underwent BCS at our institute between 2006 and 2015, were retrospectively reviewed. The results of IFSA and the pathological findings of final reanalyzed frozen tissue specimens were analyzed. Results In total, 25 patients were included in our analysis. None of the patients required additional operations. The correct diagnosis rate for IFSA was 89.6%, with a sensitivity and specificity of 60.0% and 95.8%, respectively. Conclusion IFSA could be beneficial for determining safety resection margins in patients with DCIS.

406: Upper Urinary Tract Recurrence Following Radical Cystectomy for Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 135-135
Author(s):  
Junya Furukawa ◽  
Hideaki Miyake ◽  
Kazushi Tanaka ◽  
Atsushi Takenaka ◽  
Isao Hara ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Tract ◽  
Radical Cystectomy ◽  
Upper Urinary Tract

Clinical outcome of bacillus Calmette-Guerin perfusion therapy for carcinoma in situ of the upper urinary tract

2002 ◽  
Vol 9 (12) ◽  
pp. 677-680 ◽  
Author(s):  
HIDEAKI MIYAKE ◽  
HIROSHI ETO ◽  
SHOJI HARA ◽  
HIROSHI OKADA ◽  
SADAO KAMIDONO ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Clinical Outcome ◽  
Carcinoma In Situ ◽  
Upper Urinary Tract ◽  
Bacillus Calmette Guerin
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