Effects of Octreotide on Liver Metastasis and Intrametastatic Lipid Peroxidation in Experimental Pancreatic Cancer

Oncology ◽  
2001 ◽  
Vol 60 (3) ◽  
pp. 282-288 ◽  
Author(s):  
F.A. Wenger ◽  
M. Kilian ◽  
C.A. Jacobi ◽  
I. Mautsch ◽  
F.J. Peter ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lipid Peroxidation ◽  
Liver Metastasis ◽  
Experimental Pancreatic Cancer

Influence of Octreotide on Liver Metastasis and Hepatic Lipid Peroxidation in BOP-Induced Pancreatic Cancer in Syrian Hamsters

Pancreas ◽  
2001 ◽  
Vol 23 (3) ◽  
pp. 266-272 ◽  
Author(s):  
F. A. Wenger ◽  
M. Kilian ◽  
I. Mautsch ◽  
C. A. Jacobi ◽  
A. Steiert ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lipid Peroxidation ◽  
Liver Metastasis ◽  
Syrian Hamsters ◽  
Hepatic Lipid ◽  
Hepatic Lipid Peroxidation

Impact of taurolidin and octreotide on liver metastasis and lipid peroxidation after laparoscopy in chemical induced ductal pancreatic cancer

2005 ◽  
Vol 23 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Maik Kilian ◽  
Jan Ilga Gregor ◽  
Ina Heukamp ◽  
Chris Braumann ◽  
Hans Guski ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lipid Peroxidation ◽  
Liver Metastasis ◽  
Ductal Pancreatic Cancer

Effects of celebrex and zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in syrian hamsters

2001 ◽  
Vol 37 ◽  
pp. S110
Author(s):  
F.A. Wenger ◽  
M. Kilian ◽  
I. Schimke ◽  
H. Guski ◽  
C.A. Jacobi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Syrian Hamsters

TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer

2021 ◽  
Vol 218 (11) ◽  
Author(s):  
Chris D. Hermann ◽  
Benjamin Schoeps ◽  
Celina Eckfeld ◽  
Enkhtsetseg Munkhbaatar ◽  
Lukas Kniep ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Mouse Models ◽  
Pancreatic Tumors ◽  
Primary Tumors ◽  
Increased Risk ◽  
Metastasis Development ◽  
Male Specific ◽  
Sex Disparity ◽  
Timp1 Expression

Sex disparity in cancer is so far inadequately considered, and components of its basis are rather unknown. We reveal that male versus female pancreatic cancer (PC) patients and mice show shortened survival, more frequent liver metastasis, and elevated hepatic metastasis-promoting gene expression. Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic tumors. Male-specific up-regulation of systemic TIMP1 was demonstrated in PC mouse models and patients. Using TIMP1-competent and TIMP1-deficient PC mouse models, we established a causal role of TIMP1 in determining shortened survival and increased liver metastasis in males. Observing TIMP1 expression as a risk parameter in males led to identification of a subpopulation exhibiting increased TIMP1 levels (T1HI males) in both primary tumors and blood. T1HI males showed increased risk for liver metastasis development not only in PC but also in colorectal cancer and melanoma. This study reveals a lifestyle-independent sex disparity in liver metastasis and may open new avenues toward precision medicine.

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