A case of pancreatic panniculitis （pancreatic cancer with liver metastasis） complicated by polyarthritis with erythema and nodules as initial manifestations

2020 ◽  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Pancreatic Panniculitis

Effects of celebrex and zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in syrian hamsters

2001 ◽  
Vol 37 ◽  
pp. S110
Author(s):  
F.A. Wenger ◽  
M. Kilian ◽  
I. Schimke ◽  
H. Guski ◽  
C.A. Jacobi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Syrian Hamsters

TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer

2021 ◽  
Vol 218 (11) ◽  
Author(s):  
Chris D. Hermann ◽  
Benjamin Schoeps ◽  
Celina Eckfeld ◽  
Enkhtsetseg Munkhbaatar ◽  
Lukas Kniep ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Mouse Models ◽  
Pancreatic Tumors ◽  
Primary Tumors ◽  
Increased Risk ◽  
Metastasis Development ◽  
Male Specific ◽  
Sex Disparity ◽  
Timp1 Expression

Sex disparity in cancer is so far inadequately considered, and components of its basis are rather unknown. We reveal that male versus female pancreatic cancer (PC) patients and mice show shortened survival, more frequent liver metastasis, and elevated hepatic metastasis-promoting gene expression. Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic tumors. Male-specific up-regulation of systemic TIMP1 was demonstrated in PC mouse models and patients. Using TIMP1-competent and TIMP1-deficient PC mouse models, we established a causal role of TIMP1 in determining shortened survival and increased liver metastasis in males. Observing TIMP1 expression as a risk parameter in males led to identification of a subpopulation exhibiting increased TIMP1 levels (T1HI males) in both primary tumors and blood. T1HI males showed increased risk for liver metastasis development not only in PC but also in colorectal cancer and melanoma. This study reveals a lifestyle-independent sex disparity in liver metastasis and may open new avenues toward precision medicine.

scholarly journals LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer: Erratum

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10171-10172
Author(s):  
Biao Zheng ◽  
Jianhua Qu ◽  
Kenoki Ohuchida ◽  
Haimin Feng ◽  
Stephen Jun Fei Chong ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
High Liver

Survival benefit of KRN7000 immune therapy in combination with TNP470 in hamster liver metastasis model of pancreatic cancer

2003 ◽  
Author(s):  
Gaku Matsumoto ◽  
Shigenori Nagai ◽  
Mariko Muta ◽  
Koji Tsuruta ◽  
Atsutake Okamoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Survival Benefit ◽  
Immune Therapy ◽  
Metastasis Model

A Phase I/Ib trial of Ad-REIC in liver cancer: study protocol

2019 ◽  
Vol 15 (31) ◽  
pp. 3547-3554 ◽  
Author(s):  
Astushi Oyama ◽  
Hidenori Shiraha ◽  
Daisuke Uchida ◽  
Masaya Iwamuro ◽  
Hironari Kato ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Phase I ◽  
Liver Tumor ◽  
Objective Response ◽  
University Hospital ◽  
Open Label ◽  
Safety And Efficacy ◽  
Immortalized Cells ◽  
Dose Limiting Toxicity

This study will assess the safety and efficacy of the administration of adenoviral vector expressing the human-reduced expression in immortalized cells (Ad-REIC) to a liver tumor in patients with hepatocellular carcinoma (HCC) or liver metastasis of pancreatic cancer. A Phase I clinical study of Ad-REIC administration to a liver tumor in a patient with HCC or liver metastasis of pancreatic cancer will be conducted. The study is a single-arm, prospective, nonrandomized, noncomparative, open-label, single-center trial performed in Okayama University Hospital, Okayama, Japan. Ad-REIC will be injected into the liver tumor under ultrasound guidance. Ad-REIC administration will be repeated a total of three-times every 2 weeks. The primary end point is the dose-limiting toxicity and incidence of adverse events. The secondary end points are the objective response rate and disease control rate. This study aims to expand the indication of Ad-REIC by assessing its safety and efficacy in patients with HCC or liver metastasis of pancreatic cancer.

scholarly journals Current Role of Surgery in Pancreatic Cancer With Synchronous Liver Metastasis

2020 ◽  
Vol 27 (1) ◽  
pp. 107327482097659
Author(s):  
Wentao Zhou ◽  
Dansong Wang ◽  
Wenhui Lou
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Synchronous Liver Metastasis ◽  
Long Term Outcomes ◽  
Short And Long Term ◽  
Current Guidelines

Pancreatic cancer with synchronous liver metastasis has an extremely poor prognosis, and surgery is not recommended for such patients by the current guidelines. However, an increasing body of studies have shown that concurrent resection of pancreatic cancer and liver metastasis is not only technically feasible but also beneficial to the survival in the selected patients. In this review, we aim to summarize the short- and long-term outcomes following synchronous liver metastasectomy for pancreatic cancer patients, and discuss the potential criteria in selecting appropriate surgical candidates, which might be helpful in clinical decision-making.

scholarly journals Adjuvant Trametinib Delays the Outgrowth of Occult Pancreatic Cancer in a Mouse Model of Patient-Derived Liver Metastasis

2016 ◽  
Vol 23 (6) ◽  
pp. 1993-2000 ◽  
Author(s):  
Timothy E. Newhook ◽  
James M. Lindberg ◽  
Sara J. Adair ◽  
Alison J. Kim ◽  
Edward B. Stelow ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Mouse Model

Prevention against liver metastasis by combination of gemcitabine and whole liver irradiation after pancreatic cancer surgery

2005 ◽  
Vol 9 (4) ◽  
pp. 613-613
Author(s):  
Y IKEMATSU ◽  
H KURODA ◽  
H MORIUCHI ◽  
K GOTO ◽  
T YAMAMOTO ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Cancer Surgery
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