Senile Dementia of the Neurofibrillary Tangle Type: A Comparison with Alzheimer’s Disease

2001 ◽  
Vol 12 (2) ◽  
pp. 117-126 ◽  
Author(s):  
Masahito Yamada ◽  
Yoshinori Itoh ◽  
Nobuyuki Sodeyama ◽  
Naomi Suematsu ◽  
Eiichi Otomo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Senile Dementia ◽  
Neurofibrillary Tangle ◽  
Type A ◽  
Senile Dementia Of The

Understanding Senile Dementia: A Challenge for the Future

1983 ◽  
Vol 16 (1) ◽  
pp. 1-6
Author(s):  
Martha Storandt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Differential Diagnosis ◽  
Structural Changes ◽  
Senile Dementia ◽  
Accelerated Aging ◽  
Later Life ◽  
The Future ◽  
Supportive Environments ◽  
Senile Dementia Of The

The causes of dementia in later life are reviewed. Special attention is paid to senile dementia of the Alzheimer's type, its prevelance, the characteristic structural changes in the brains of persons suffering from this disorder, and the hypothesized causes of the disease. The hypothesis that Alzheimer's disease represents accelerated aging is described. Treatment issues are discussed, primarily in terms of supportive environments, differential diagnosis, and assistance to the caregiver.

A quantitative comparison of plaque types in Alzheimer's disease and senile dementia of the Lewy body type

1996 ◽  
Vol 91 (5) ◽  
pp. 526-529 ◽  
Author(s):  
Jeanette E. McKenzie ◽  
Richard J. Edwards ◽  
Stephen M. Gentleman ◽  
Paul G. Ince ◽  
Robert H. Perry ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Senile Dementia ◽  
Quantitative Comparison ◽  
Body Type ◽  
Senile Dementia Of The

Membrane Components Separate Early-Onset Alzheimer's Disease From Senile Dementia of the Alzheimer Type

1996 ◽  
Vol 8 (3) ◽  
pp. 365-372 ◽  
Author(s):  
Carl-Gerhard Gottfries ◽  
Ingvar Karlsson ◽  
Lars Svennerholm
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Brain Tissue ◽  
Membrane Lipids ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Synapse Degeneration ◽  
Membrane Components ◽  
Senile Dementia Of The

Brain tissue from 12 subjects with pure Alzheimer's disease (AD) and 21 subjects with senile dementia of the Alzheimer type (SDAT) was investigated for membrane lipids and compared with that in age-matched controls. In brain tissue from the patients with AD, phospholipids were significantly decreased compared with that from SDAT patients and controls, cholesterol was reduced compared with that in controls, and gangliosides were significantly reduced in all gray-matter areas investigated compared with those in both SDAT subjects and controls. A reduction in gangliosides also occurred in the SDAT group, but it was smaller. In the white matter, the pattern of changes was the opposite. Phospholipids, cholesterol, cerebroside, and sulfatide were significantly reduced in the frontal-lobe white matter in the SDAT group compared with that in age-matched controls and AD patients. Gangliosides in the cerebrospinal fluid also separated AD from SDAT and controls. The findings indicate synapse degeneration as an important pathogenetic factor in AD. This disorder should be separated from SDAT, in which white-matter degeneration appears to be more prominent.

Sign in / Sign up

Export Citation Format

Share Document