Clinical trials with the cholinergic drug RS 86 in Alzheimer's disease (AD) and senile dementia of the Alzheimer type (SDAT)

1984 ◽  
Vol 84 (4) ◽  
pp. 572-573 ◽  
Author(s):  
Albert Wettstein ◽  
Ren� Spiegel
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Senile Dementia Of The ◽  
Cholinergic Drug

Membrane Components Separate Early-Onset Alzheimer's Disease From Senile Dementia of the Alzheimer Type

1996 ◽  
Vol 8 (3) ◽  
pp. 365-372 ◽  
Author(s):  
Carl-Gerhard Gottfries ◽  
Ingvar Karlsson ◽  
Lars Svennerholm
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Brain Tissue ◽  
Membrane Lipids ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Synapse Degeneration ◽  
Membrane Components ◽  
Senile Dementia Of The

Brain tissue from 12 subjects with pure Alzheimer's disease (AD) and 21 subjects with senile dementia of the Alzheimer type (SDAT) was investigated for membrane lipids and compared with that in age-matched controls. In brain tissue from the patients with AD, phospholipids were significantly decreased compared with that from SDAT patients and controls, cholesterol was reduced compared with that in controls, and gangliosides were significantly reduced in all gray-matter areas investigated compared with those in both SDAT subjects and controls. A reduction in gangliosides also occurred in the SDAT group, but it was smaller. In the white matter, the pattern of changes was the opposite. Phospholipids, cholesterol, cerebroside, and sulfatide were significantly reduced in the frontal-lobe white matter in the SDAT group compared with that in age-matched controls and AD patients. Gangliosides in the cerebrospinal fluid also separated AD from SDAT and controls. The findings indicate synapse degeneration as an important pathogenetic factor in AD. This disorder should be separated from SDAT, in which white-matter degeneration appears to be more prominent.

An HLA and family study of Alzheimer's disease

1984 ◽  
Vol 14 (3) ◽  
pp. 515-520 ◽  
Author(s):  
E. B. Renvoize
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family Study ◽  
Senile Dementia ◽  
Alzheimer Type ◽  
Histocompatibility Antigens ◽  
Presenile Dementia ◽  
Hla Antigen ◽  
Weak Association ◽  
Senile Dementia Of The

SynopsisHistocompatibility antigens were examined in 124 patients with Alzheimer's disease (AD), and the frequency of HLA-B15 was found to be significantly increased over controls. Pooling of data from the present and similar studies suggests that AD is not strongly associated with any particular HLA antigen, although there may be a weak association with HLA-A2, B15 and Cw3. In a family study of 34 patients with AD, secondary cases of AD were identified in 9·7% of the first-degree relatives, and cases of presenile dementia and senile dementia of the Alzheimer type were found to occur within individual families.

scholarly journals Irregular Distortion of The Erythrocytes (Acanthocytes, Spur Cells) in Senile Dementia

1994 ◽  
Vol 12 (1) ◽  
pp. 23-41 ◽  
Author(s):  
H. B. Goodall ◽  
A. H. Reid ◽  
D. J. Findlay ◽  
C. Hind ◽  
J. Kay ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Membrane ◽  
Senile Dementia ◽  
Red Cells ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type

An excess of irregularly di storted red cells with spiked forms (acanthocytes. spur cells) has been found in a substantial minority of patient s with seni le dementia of Alzheimer type (7 of 50 patients, 3 of 21 men and 4 of 29 women). Of 100 control patients, 42 men and 58 women), 5 (men and 2 women) showed comparable distortion, but, of these, one man may well have incipient dementia and the others had serious organic di seases which may be associated with comparable erythrocytic changes. The cause of the distortion is not yet clear, but the presence of occasional giant erythrocytes in the absence of general macrocytosis suggests a possible abnormality of cell membrane synthes is. This distortion may be a useful marker in patients with loss of memory. Whether it is a manifestation of a haemopoietic clone or a constitutional anomaly associated with Alzheimer’s disease remains to be seen.

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