Hepatic Tissue Engineering on 3-Dimensional Biodegradable Polymers within a Pulsatile Flow Bioreactor

2001 ◽  
Vol 18 (3) ◽  
pp. 196-203 ◽  
Author(s):  
É. Török ◽  
J.-M. Pollok ◽  
P.X. Ma ◽  
C. Vogel ◽  
M. Dandri ◽  
...  
2015 ◽  
Vol 103 (10) ◽  
pp. 3331-3338 ◽  
Author(s):  
Kelly R. Stevens ◽  
Jordan S. Miller ◽  
Brandon L. Blakely ◽  
Christopher S. Chen ◽  
Sangeeta N. Bhatia

2006 ◽  
Vol 21 (1) ◽  
pp. 23-37 ◽  
Author(s):  
K. Hu ◽  
Q. Lv ◽  
F. Z. Cui ◽  
Q. L. Feng ◽  
X. D. Kong ◽  
...  

1993 ◽  
pp. 92-107 ◽  
Author(s):  
Mehmet Toner ◽  
Ronald G. Tompkins ◽  
Martin L. Yarmush

Author(s):  
Fran√ßois Berthiaume ◽  
Arno W.Tilles ◽  
Martin L.Yarmush ◽  
Mehmet Toner ◽  
Christina Chan

Author(s):  
Raffaele Conte ◽  
Francesco Riccitiello ◽  
Adriana De Luise ◽  
Orsolina Petillo ◽  
Carlo Rengo ◽  
...  

2010 ◽  
Vol 93-94 ◽  
pp. 121-124
Author(s):  
Nuttapon Vachiraroj ◽  
Siriporn Damrongsakkul ◽  
Sorada Kanokpanont

In this work, we developed a 3-dimensional bone tissue engineering scaffold from type B gelatin and hydroxyapatite. Two types of scaffolds, pure gelatin (pI~5) (Gel) and gelatin/hydroxyapatite (30/70 wt./wt.) (Gel/HA), were prepared from concentrated solutions (5% wt./wt.) using foaming/freeze drying method. The results SEM revealed the interconnected-homogeneous pores of Gel and Gel/HA were 121  119 and 148  83m, respectively. Hydroxyapatite improved mechanical property of the gelatin scaffolds, especially at dry state. Compressive modulus of Gel and Gel/HA scaffolds were at 118±21.68 and 510±109.08 kPa, respectively. The results on in vitro cells culture showed that Gel/HA scaffolds promoted attachment of rat’s mesenchymal stem cells (MSC) to a 1.23 folds higher than the Gel scaffolds. Population doubling time (PDT) of MSC on Gel and Gel/HA scaffolds were 51.16 and 54.89 hours, respectively. In term of osteogenic differentiation, Gel/HA scaffolds tended to enhance ALP activity and calcium content of MSC better than those of the Gel scaffold. Therefore the Gel/HA scaffolds had a potential to be applied in bone tissue engineering.


1995 ◽  
Vol 394 ◽  
Author(s):  
Jeffrey S. Hrkach ◽  
Jean Ou ◽  
Noah Lotan ◽  
Robert Langer

AbstractOne of the challenges in the field of tissue engineering is the development of optimal materials for use as scaffolds to support cell growth and tissue development. For this purpose, we are developing synthetic, biodegradable polymers with functional sites that provide the opportunity to covalently attach biologically active molecules to the polymers, so they can predictably interact with cells in a favorable manner to enhance cell attachment and growth. The preparation of poly(L-lactic acid-co-aspartic acid) comb-like graft copolymers from poly(L-lactic acid-co-β-benzyl-L-aspartate), and the casting of polymer films by solvent evaporation were carried out.


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