scholarly journals Degradable hydrogels derived from PEG‐diacrylamide for hepatic tissue engineering

2015 ◽  
Vol 103 (10) ◽  
pp. 3331-3338 ◽  
Author(s):  
Kelly R. Stevens ◽  
Jordan S. Miller ◽  
Brandon L. Blakely ◽  
Christopher S. Chen ◽  
Sangeeta N. Bhatia
Keyword(s):  
Tissue Engineering ◽  
Hepatic Tissue

Biocompatible Fibroin Blended Films with Recombinant Human-like Collagen for Hepatic Tissue Engineering

2006 ◽  
Vol 21 (1) ◽  
pp. 23-37 ◽  
Author(s):  
K. Hu ◽  
Q. Lv ◽  
F. Z. Cui ◽  
Q. L. Feng ◽  
X. D. Kong ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hepatic Tissue

Liver Support Through Hepatic Tissue Engineering

1993 ◽  
pp. 92-107 ◽  
Author(s):  
Mehmet Toner ◽  
Ronald G. Tompkins ◽  
Martin L. Yarmush
Keyword(s):  
Tissue Engineering ◽  
Hepatic Tissue ◽  
Liver Support

Hepatic Tissue Engineering for Adjunct and Temporary Liver Support

2006 ◽  
pp. 59-1-59-19
Author(s):  
Fran√ßois Berthiaume ◽  
Arno W.Tilles ◽  
Martin L.Yarmush ◽  
Mehmet Toner ◽  
Christina Chan
Keyword(s):  
Tissue Engineering ◽  
Hepatic Tissue ◽  
Liver Support

Development of hepatic tissue engineering

2009 ◽  
Vol 25 (8) ◽  
pp. 667-673 ◽  
Author(s):  
Henning Cornelius Fiegel ◽  
Ulrich Kneser ◽  
Dietrich Kluth ◽  
Roman Metzger ◽  
Holger Till ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hepatic Tissue

Assessing Porcine Liver-Derived Biomatrix for Hepatic Tissue Engineering

2004 ◽  
Vol 10 (7) ◽  
pp. 1046-1053 ◽  
Author(s):  
Paul Lin ◽  
Warren C.W. Chan ◽  
Stephen F. Badylak ◽  
Sangeeta N. Bhatia
Keyword(s):  
Tissue Engineering ◽  
Hepatic Tissue ◽  
Porcine Liver

scholarly journals Poly(ε-Caprolactone) Hollow Fiber Membranes for the Biofabrication of a Vascularized Human Liver Tissue

Membranes ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 112
Author(s):  
Simona Salerno ◽  
Franco Tasselli ◽  
Enrico Drioli ◽  
Loredana De Bartolo
Keyword(s):  
Tissue Engineering ◽  
Endothelial Cells ◽  
Hollow Fiber ◽  
Liver Tissue ◽  
External Surface ◽  
Internal Surface ◽  
Hepatic Tissue ◽  
Operational Parameters ◽  
Human Organ ◽  
Human Liver Tissue

The creation of a liver tissue that recapitulates the micro-architecture and functional complexity of a human organ is still one of the main challenges of liver tissue engineering. Here we report on the development of a 3D vascularized hepatic tissue based on biodegradable hollow fiber (HF) membranes of poly(ε-caprolactone) (PCL) that compartmentalize human hepatocytes on the external surface and between the fibers, and endothelial cells into the fiber lumen. To this purpose, PCL HF membranes were prepared by a dry-jet wet phase inversion spinning technique tailoring the operational parameters in order to obtain fibers with suitable properties. After characterization, the fibers were applied to generate a human vascularized hepatic unit by loading endothelial cells in their inner surface and hepatocytes on the external surface. The unit was connected to a perfusion system, and the morpho-functional behavior was evaluated. The results demonstrated the large integration of endothelial cells with the internal surface of individual PCL fibers forming vascular-like structures, and hepatocytes covered completely the external surface and the space between fibers. The perfused 3D hepatic unit retained its functional activity at high levels up to 18 days. This bottom-up tissue engineering approach represents a rational strategy to create relatively 3D vascularized tissues and organs.

Collagen/Chitosan/Heparin Complex with Improved Biocompatibility for Hepatic Tissue Engineering

2005 ◽  
Vol 20 (1) ◽  
pp. 15-28 ◽  
Author(s):  
Xing Yu ◽  
Alexandra Bichtelen ◽  
Xiaohong Wang ◽  
Yongnian Yan ◽  
Feng Lin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hepatic Tissue
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