Hypoxia-Induced Changes in Extracellular Matrix Metabolism in Renal Cells

1999 ◽  
Vol 7 (5-6) ◽  
pp. 463-469 ◽  
Author(s):  
J.T. Norman ◽  
C. Orphanides ◽  
P. Garcia ◽  
L.G. Fine
Keyword(s):  
Extracellular Matrix ◽  
Renal Cells ◽  
Matrix Metabolism ◽  
Induced Changes

scholarly journals Connective Tissue Metabolism and Gingival Overgrowth

2004 ◽  
Vol 15 (3) ◽  
pp. 165-175 ◽  
Author(s):  
P. C. Trackman ◽  
A. Kantarci
Keyword(s):  
Extracellular Matrix ◽  
Connective Tissue ◽  
Oral Hygiene ◽  
Tissue Specificity ◽  
Gingival Fibroblast ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Connective Tissue Metabolism ◽  
Matrix Metabolism ◽  
Systemic Health

Gingival overgrowth occurs mainly as a result of certain anti-seizure, immunosuppressive, or antihypertensive drug therapies. Excess gingival tissues impede oral function and are disfiguring. Effective oral hygiene is compromised in the presence of gingival overgrowth, and it is now recognized that this may have negative implications for the systemic health of affected patients. Recent studies indicate that cytokine balances are abnormal in drug-induced forms of gingival overgrowth. Data supporting molecular and cellular characteristics that distinguish different forms of gingival overgrowth are summarized, and aspects of gingival fibroblast extracellular matrix metabolism that are unique to gingival tissues and cells are reviewed. Abnormal cytokine balances derived principally from lymphocytes and macrophages, and unique aspects of gingival extracellular matrix metabolism, are elements of a working model presented to facilitate our gaining a better understanding of mechanisms and of the tissue specificity of gingival overgrowth.

scholarly journals Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Meenalakshmi M. Mariappan
Keyword(s):  
Extracellular Matrix ◽  
Signaling Pathways ◽  
Matrix Protein ◽  
Structural Changes ◽  
Mammalian Target Of Rapamycin ◽  
Adverse Outcomes ◽  
Matrix Proteins ◽  
Extracellular Matrix Protein ◽  
Renal Hypertrophy ◽  
Matrix Metabolism

Renal hypertrophy and accumulation of extracellular matrix proteins are among cardinal manifestations of diabetic nephropathy. TGF beta system has been implicated in the pathogenesis of these manifestations. Among signaling pathways activated in the kidney in diabetes, mTOR- (mammalian target of rapamycin-)regulated pathways are pivotal in orchestrating high glucose-induced production of ECM proteins leading to functional and structural changes in the kidney culminating in adverse outcomes. Understanding signaling pathways that influence individual matrix protein expression could lead to the development of new interventional strategies. This paper will highlight some of the diverse components of the signaling network stimulated by hyperglycemia with an emphasis on extracellular matrix protein metabolism in the kidney in diabetes.

scholarly journals Extracellular matrix metabolism disorder induced by mechanical strain on human parametrial ligament fibroblasts

2017 ◽  
Vol 15 (5) ◽  
pp. 3278-3284 ◽  
Author(s):  
Jie Min ◽  
Bingshu Li ◽  
Cheng Liu ◽  
Wenjun Guo ◽  
Shasha Hong ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Mechanical Strain ◽  
Metabolism Disorder ◽  
Matrix Metabolism

Synergistically regulated spontaneous calcium signaling is attributed to cartilaginous extracellular matrix metabolism

2018 ◽  
Vol 234 (6) ◽  
pp. 9711-9722 ◽  
Author(s):  
Xiaoyuan Gong ◽  
Gaoming Li ◽  
Yang Huang ◽  
Zhenlan Fu ◽  
Xiongbo Song ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Calcium Signaling ◽  
Matrix Metabolism

scholarly journals Dynamic Changes in Cervical Glycosaminoglycan Composition during Normal Pregnancy and Preterm Birth

Endocrinology ◽  
2012 ◽  
Vol 153 (7) ◽  
pp. 3493-3503 ◽  
Author(s):  
Yucel Akgul ◽  
Roxane Holt ◽  
Mark Mummert ◽  
Ann Word ◽  
Mala Mahendroo
Keyword(s):  
Extracellular Matrix ◽  
Preterm Birth ◽  
Normal Pregnancy ◽  
Dynamic Changes ◽  
Macromolecular Assembly ◽  
Large Structures ◽  
Ha Synthase ◽  
Metabolizing Enzyme ◽  
Induced Changes ◽  
Human Cervix

Glycosaminoglycans (GAG) have diverse functions that regulate macromolecular assembly in the extracellular matrix. During pregnancy, the rigid cervix transforms to a pliable structure to allow birth. Quantitative assessment of cervical GAG is a prerequisite to identify GAG functions in term and preterm birth. In the current study, total GAG levels increased at term, yet the abundance, chain length, and sulfation levels of sulfated GAG remained constant. The increase in total GAG resulted exclusively from an increase in hyaluronan (HA). HA can form large structures that promote increased viscosity, hydration, and matrix disorganization as well as small structures that have roles in inflammation. HA levels increased from 19% of total GAG in early pregnancy to 71% at term. Activity of the HA-metabolizing enzyme, hyaluronidase, increased in labor, resulting in metabolism of large to small HA. Similar to mice, HA transitions from high to low molecular weight in term human cervix. Mouse preterm models were also characterized by an increase in HA resulting from differential expression of the HA synthase (Has) genes, with increased Has1 in preterm in contrast to Has2 induction at term. The Has2 gene but not Has1 is regulated in part by estrogen. These studies identify a shift in sulfated GAG dominance in the early pregnant cervix to HA dominance in term and preterm ripening. Increased HA synthesis along with hyaluronidase-induced changes in HA size in mice and women suggest diverse contributions of HA to macromolecular changes in the extracellular matrix, resulting in loss of tensile strength during parturition.

Cytotoxicity of three commercial mouthrinses on extracellular matrix metabolism and human gingival cell behaviour

2016 ◽  
Vol 34 ◽  
pp. 88-96 ◽  
Author(s):  
Stefania Balloni ◽  
Paola Locci ◽  
Alessandro Lumare ◽  
Lorella Marinucci
Keyword(s):  
Extracellular Matrix ◽  
Cell Behaviour ◽  
Matrix Metabolism

MARKERS OF EXTRACELLULAR MATRIX METABOLISM IN PEDIATRIC PATIENTS WITH ACUTE LUNG INJURY

1999 ◽  
Vol 27 (Supplement) ◽  
pp. 160A
Author(s):  
Michael Kelly ◽  
Jacqueline Sjoberg-Gilker ◽  
Hartmut Hanausake ◽  
Bruce M. Greenwald
Keyword(s):  
Extracellular Matrix ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Pediatric Patients ◽  
Matrix Metabolism
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