The application of AFLP fingerprinting to construct a YAC contig containing ADH2 and MTP on sheep chromosome 6

1999 ◽  
Vol 84 (3-4) ◽  
pp. 225-229 ◽  
Author(s):  
J.M. Lumsden ◽  
E.A. Lord ◽  
S.A. Cato ◽  
T.E. Richardson ◽  
T.C. van Stijn ◽  
...  
Keyword(s):  
Chromosome 6 ◽  
Aflp Fingerprinting ◽  
Sheep Chromosome ◽  
Yac Contig

Characterisation and mapping of the Booroola (FecB) gene using regression analysis in sheep

2000 ◽  
Vol 2000 ◽  
pp. 41-41
Author(s):  
G.A. Walling ◽  
K.G. Dodds ◽  
S.M. Galloway ◽  
A.E. Beattie ◽  
E.A. Lord ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linkage Analysis ◽  
Ovulation Rate ◽  
Chromosome 6 ◽  
Female Progeny ◽  
Gene Effect ◽  
Sheep Chromosome ◽  
Genotype Assignment ◽  
Constant Gene ◽  
Breeding Seasons

The Booroola Merino strain of sheep carries a major autosomal mutation (FecB) which increases ovulation rate (Davis et al., 1982). To map the gene, heterozygous sires (B+) were mated to non-carrier ewes (++). The female progeny were then examined by laproscopy to determine ovulation rates and these phenotypes used to assign progeny genotypes (B+, ++ or undetermined). Linkage analysis between the assigned Booroola genotype and a set of marker genotypes was used to assign the Booroola gene to a region of sheep chromosome 6 (OOV6) (Montgomery et al., 1994). These studies relied on accurate genotype assignment and a constant gene effect across animals and breeding seasons. This study aims to use regression analysis to verify the validity of these assumptions.

The consequences of carrying the Booroola fecundity (FecB) gene on sheep liveweight

2000 ◽  
Vol 2000 ◽  
pp. 43-43 ◽  
Author(s):  
G.A. Walling ◽  
K.G. Dodds ◽  
S.M. Galloway ◽  
A.E. Beattie ◽  
E.A. Lord ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Personal Communication ◽  
Pleiotropic Effect ◽  
Ovulation Rate ◽  
Chromosome 6 ◽  
Sheep Chromosome ◽  
Trait Locus ◽  
Fertility Traits

The increase in ovulation rate caused by the Booroola gene was first observed in the Booroola Merino strain of sheep (Davis et al., 1982) and the gene was subsequently mapped to sheep chromosome 6 (OOV6) (Montgomery et al. 1994). The low heritability of fertility traits and the desire to produce more lambs per ewe from meat breeds has lead to many crossbreeding programs seeking to obtain the benefits of the Booroola gene. However, many producers report animals carrying a Booroola allele to be lighter than non-carriers (G. Davis, personal communication). The Booroola Merino strain of sheep is typically lighter than recipient breeds used in the introgression programmes e.g. Romney. This study aims to determine whether the Booroola gene has a pleiotropic effect on liveweight or whether there is any evidence to suggest a closely linked quantitative trait locus (QTL) affecting liveweight that may ‘hitchhike’ with the Booroola gene.

The linkage map of sheep Chromosome 6 compared with orthologous regions in other species

1996 ◽  
Vol 7 (5) ◽  
pp. 373-376 ◽  
Author(s):  
E. A. Lord ◽  
J. M. Lumsden ◽  
K. G. Dodds ◽  
H. M. Henry ◽  
A. M. Crawford ◽  
...  
Keyword(s):  
Linkage Map ◽  
Chromosome 6 ◽  
Sheep Chromosome

Seven loci on human Chromosome 4 map onto sheep Chromosome 6: a proposal to restore the original nomenclature of this sheep chromosome

1994 ◽  
Vol 5 (7) ◽  
pp. 429-433 ◽  
Author(s):  
T. E. Broad ◽  
D. J. Burkin ◽  
L. M. Cambridge ◽  
D. W. Maher ◽  
P. E. Lewis ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 6 ◽  
Chromosome 4 ◽  
Sheep Chromosome ◽  
Human Chromosome 4

The Booroola Fecundity (FecB) Gene Maps to Sheep Chromosome 6

Genomics ◽  
1994 ◽  
Vol 22 (1) ◽  
pp. 148-153 ◽  
Author(s):  
Grant W. Montgomery ◽  
Eric A. Lord ◽  
Joanne M. Penty ◽  
Ken G. Dodds ◽  
Tom E. Broad ◽  
...  
Keyword(s):  
Chromosome 6 ◽  
Sheep Chromosome ◽  
Gene Maps

A 2-Mb YAC Contig Linking the Plasminogen-Apoprotein(a) Gene Family to the Insulin-like Growth Factor 2 Receptor (IGF2R) Gene on the Telomeric Region of Chromosome 6 (6q26-q27)

Genomics ◽  
1994 ◽  
Vol 22 (3) ◽  
pp. 664-666 ◽  
Author(s):  
Francesco Acquati ◽  
Nicoletta Malgaretti ◽  
Robert Hauptschein ◽  
Pulivarthi Rao ◽  
Gianluca Gaidano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Family ◽  
Telomeric Region ◽  
Chromosome 6 ◽  
Insulin Like Growth Factor ◽  
Yac Contig

The gonadotrophin-releasing hormone receptor maps to sheep Chromosome 6 outside of the region of the FecB locus

1995 ◽  
Vol 6 (6) ◽  
pp. 436-438 ◽  
Author(s):  
G. W. Montgomery ◽  
J. M. Penty ◽  
E. A. Lord ◽  
J. Brooks ◽  
A. S. McNeilly
Keyword(s):  
Hormone Receptor ◽  
Chromosome 6 ◽  
Releasing Hormone ◽  
Sheep Chromosome ◽  
Gonadotrophin Releasing Hormone

scholarly journals Generation of a high-resolution genetic map and a YAC contig of the Lurcher locus on mouse chromosome 6.

1995 ◽  
Vol 5 (4) ◽  
pp. 381-392 ◽  
Author(s):  
J Zuo ◽  
P L De Jager ◽  
D J Norman ◽  
N Heintz
Keyword(s):  
High Resolution ◽  
Mouse Chromosome ◽  
Genetic Map ◽  
Chromosome 6 ◽  
Yac Contig

A 2-Mb YAC Contig and Physical Map of the Natural Killer Gene Complex on Mouse Chromosome 6

Genomics ◽  
1997 ◽  
Vol 42 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Michael G. Brown ◽  
Susanna Fulmek ◽  
Keiko Matsumoto ◽  
Robert Cho ◽  
Paul A. Lyons ◽  
...  
Keyword(s):  
Natural Killer ◽  
Mouse Chromosome ◽  
Physical Map ◽  
Chromosome 6 ◽  
Gene Complex ◽  
Natural Killer Gene Complex ◽  
Yac Contig ◽  
Killer Gene

scholarly journals Mapping of dentin-specific acidic phosphoprotein and integrin-binding sialoprotein in sheep defines an inversion breakpoint with respect to human chromosome 4Q

1999 ◽  
Vol 22 (1) ◽  
pp. 29-31 ◽  
Author(s):  
Joanne M. Lumsden ◽  
Eric A. Lord ◽  
Karen L. Hirst ◽  
Michael J. Dixon ◽  
Grant W. Montgomery
Keyword(s):  
Human Chromosome ◽  
Linkage Map ◽  
Gene Order ◽  
Breakpoint Region ◽  
Rflp Markers ◽  
Chromosome 6 ◽  
Chromosome 4 ◽  
Human Chromosome 4 ◽  
Yac Contig ◽  
Secreted Phosphoprotein 1

Genes from sheep chromosome 6 map to human chromosome 4 in the region extending from 4p16 to 4q26. However, there is an inversion of gene order in the central portion of the chromosome with one breakpoint close to secreted phosphoprotein 1 (SPP1). Genes for SPP1, integrin-binding sialoprotein (IBSP) and dentin-specific acidic phosphoprotein (DMP1) are located close together in a YAC contig in the human. RFLP markers were developed for DMP1 and IBSP in sheep and located on the sheep linkage map to further define the breakpoint region. There were no recombinants between SPP1 and IBSP indicating that these loci are close together in sheep, as in humans. DMP1 was located approximately 80 cM from SPP1 in sheep, 7 cM from the microsatellite BMC4203. In the human YAC contig, the order of these genes is SPP1-IBSP-DMP1 with 340 kb separating SPP1 and IBSP and 150 kb between IBSP and DMP1. Therefore, one breakpoint for the inversion in gene order between the sheep and the human has been narrowed to a region of 150 kb on the human map.

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