scholarly journals Clinical Experience Using a Real Time Autofluorescence Endoscopy System in the Gastrointestinal Tract

1999 ◽  
Vol 5 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Tatsuo Ogihara ◽  
Haruo Watanabe ◽  
Akihiro Namihisa ◽  
Osamu Kobayashi ◽  
Hiroto Miwa ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Early Detection ◽  
Imaging System ◽  
Screening Method ◽  
Prototype System ◽  
Low Grade ◽  
White Light Endoscopy ◽  
Normal Tissues ◽  
Autofluorescence Endoscopy ◽  
Neoplastic Tissues

Autofluorescence spectra of neoplastic tissues have been reported to be significantly different from those of normal tissues when excited by blue or violet light. From this concept, a light-induced autofluorescence endoscopic imaging system for gastrointestinal mucosa (LIFE-GI; Xillix, Canada and Olympus, Japan) has been newly developed and the clinical evaluation of the prototype system has been conducted in hospitals in Canada, Netherlands and Japan.We examined the clinical usefulness of the prototype LIFE-GI system for the detection of gastrointestinal cancer and high and low grade dysplasia. The LIFE-GI system was also applied to the early detection of remnant lesions after endoscopic treatment of early gastric cancer and to the detection of laterally spreading superficial colonic tumors.This system has potential application for the diagnosis of dysplastic lesions and early cancers in the gastrointestinal tract as an adjunct to ordinary white light endoscopy. This system, which needs no administration of a photosensitive agent, may be suitable as a screening method for the early detection of neoplastic tissues.

Development of a fluorescence video endoscopy imaging system for the early detection of cancer in the gastrointestinal tract

1997 ◽  
Author(s):  
Haishan Zeng ◽  
Alan Weiss ◽  
Calum E. MacAulay ◽  
Nick MacKinnon ◽  
Richard W. Cline ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Early Detection ◽  
Early Detection Of Cancer ◽  
Imaging System ◽  
Video Endoscopy

scholarly journals The Entire Intestinal Tract Surveillance Using Capsule Endoscopy after Immune Checkpoint Inhibitor Administration: A Prospective Observational Study

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 543
Author(s):  
Keitaro Shimozaki ◽  
Kenro Hirata ◽  
Sara Horie ◽  
Akihiko Chida ◽  
Kai Tsugaru ◽  
...  
Keyword(s):  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Early Detection ◽  
Adverse Events ◽  
Observational Study ◽  
Capsule Endoscopy ◽  
Immune Checkpoint ◽  
Intestinal Tract ◽  
Prospective Observational Study ◽  
Screening Method

Background: Despite the proven efficacy of immune checkpoint inhibitors (ICIs) against various types of malignancies, they have been found to induce immune-related adverse events, such as enterocolitis; however, the clinical features of ICI-induced enterocolitis remain to be sufficiently elucidated, which is significant, considering the importance of early detection in the appropriate management and treatment of ICI-induced enterocolitis. Therefore, the current study aimed to determine the utility of capsule endoscopy as a screening tool for ICI-induced enterocolitis. Methods: This single-center, prospective, observational study was conducted on patients with malignancy who received any ICI between April 2016 and July 2020 at Keio University Hospital. Next, second-generation capsule endoscopy (CCE-2) was performed on day 60 after ICI initiation to explore the entire gastrointestinal tract. Results: Among the 30 patients enrolled herein, 23 underwent CCE-2. Accordingly, a total of 23 findings were observed in 14 (60.8%) patients at any portion of the gastrointestinal tract (7 patients in the colon, 4 patients in the small intestine, 2 patients in both the colon and the small intestine, and 1 patient in the stomach). After capsule endoscopy, 2 patients (8.7%) developed ICI-induced enterocolitis: both had significantly higher Capsule Scoring of Ulcerative Colitis than those who had not developed ICI-induced enterocolitis (p = 0.0455). No adverse events related to CCE-2 were observed. Conclusions: CCE-2 might be a safe and useful entire intestinal tract screening method for the early detection of ICI-induced enterocolitis in patients with malignancies.

scholarly journals Analysis of Compound Stained Cervical Cell Images Using Multi-Spectral Imaging

2021 ◽  
Vol 11 (12) ◽  
pp. 5628
Author(s):  
Run Fang ◽  
Libo Zeng ◽  
Fan Yi
Keyword(s):  
Cervical Cancer ◽  
Mouse Liver ◽  
Imaging System ◽  
Color Image ◽  
Imaging Technique ◽  
Screening Method ◽  
Spectral Imaging ◽  
High Accuracy ◽  
Cervical Cell ◽  
Real World Applications

Multi-spectral imaging technique plays an important role in real-world applications such as medicine and medical detections. This paper proposes a cervical cancer cell screening method to simultaneously adopt TBS classification and DNA quantitative analysis for a single cell smear. Through using compound staining on a smear, the cytoplasm is stained by Papanicolauo and the nucleus is stained by Feulgen. The main evaluation parameter is the DNA content of the nucleus, not the subjective description of cell morphology, which is more objective than the TBS classification method and reduces the chances of missing a diagnosis due to subjective factors. Each nucleus has its own DI value and color image of the whole cell, which is convenient for doctors as it allows them to review and confirm the morphology of cells with a nucleus DI of over 2.5. Mouse liver smears and cervical cases are utilized as the measuring specimens to evaluate the performance of the microscope multi-spectral imaging system; illustrative results demonstrate that the proposed system qualifies, with high accuracy and reliability, and further presents wide application prospects in the early diagnosis of cervical cancer.

Design and Analysis of a High Power Density, Low Temperature Waste Heat Recovery System Using an Oil-Free Turboalternator

2010 ◽  
Author(s):  
James F. Walton ◽  
Andrew Hunsberger ◽  
Hooshang Heshmat
Keyword(s):  
Output Power ◽  
Waste Heat ◽  
Maximum Output Power ◽  
Output Power Level ◽  
Working Fluid ◽  
Prototype System ◽  
Low Grade ◽  
Maximum Output ◽  
Test Results ◽  
Study Results

In this paper the authors will present the design and preliminary test results for a distributed electric generating system that uses renewable energy source for economical load-following and peak-shaving capability in an oil-free, high-speed micro-turboalternator system using compliant foil bearings and a permanent magnet alternator. Test results achieved with the prototype system operating to full speed and under power generating mode will be presented. A comparison between predicted and measured electrical output will also be presented up to a power generating level of 25 kWe at approximately 55,000 rpm. The excellent correlation between design and test provides the basis for scale up to larger power levels. Based upon the turboalternator test results a thermodynamic cycle analysis of a system using low grade waste heat water at approximately 100 C will be reviewed. The tradeoff study results for a series of environmentally friendly refrigerant working fluids will also be presented including sensitivity to vaporization and condensing temperatures. Based on the cycle and pinch point analyses predicted maximum output power was determined. Finally a preliminary turbine design for the selected R134a working fluid was completed. The results of this study show that a net output power level of greater than 40 kW is possible for approximately 240 l/m flow of water at 100C is possible.

t(11; 18)(q21; q21)-Associated low-grade mucosa-associated lymphoid tissue lymphoma involving the gastrointestinal tract, the lungs, and the salivary glands

2004 ◽  
Vol 39 (12) ◽  
pp. 1220-1222
Author(s):  
Shigeo Nakamura ◽  
Takayuki Matsumoto ◽  
Shotaro Nakamura ◽  
Kazuoki Hizawa ◽  
Mitsuo Iida ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Salivary Glands ◽  
Lymphoid Tissue ◽  
Low Grade

Excised Human Neoplastic Tissues Are More Sensitive to Heat than the Adjacent Normal Tissues

1988 ◽  
Vol 20 (4) ◽  
pp. 254-259 ◽  
Author(s):  
Y. Maehara ◽  
T. Kusumoto ◽  
H. Kusumoto ◽  
H. Anai ◽  
K. Akazawa ◽  
...  
Keyword(s):  
Normal Tissues ◽  
Neoplastic Tissues

scholarly journals An Automated System To Replace A Human User In Conventional Laboratory Well Plate Imaging

2017 ◽  
Author(s):  
Connor Verheyen ◽  
Cornelis Rowaan ◽  
Bryan Gatto ◽  
Daniel Gizachew
Keyword(s):  
User Interface ◽  
Graphical User Interface ◽  
Human Error ◽  
Imaging System ◽  
Automated System ◽  
Prototype System ◽  
Successful Implementation ◽  
Two Dimensional ◽  
Image Capture ◽  
Automated Calibration

We here developed an automated well plate imaging system to eliminate the requirement for continuous human operation, thus freeing up the valuable time of a scientific researcher and removing the possibility of fatigue-induced human error. Specifically, we created a prototype system with programmed two-dimensional movement, automated calibration, variable plate configuration compatibility, variable path feasibility, reliable well plate image capture, and an intuitive graphical user interface. Successful implementation of our device would immediately benefit laboratory scientists, giving them more time to pursue the next biomedical breakthroughs.

scholarly journals Diagnostic Accuracy of Red Reflex Test (RRT) for Early Detection of Ocular Abnormalities in Newborn

2021 ◽  
pp. 185-191
Author(s):  
Kshitij Aviraj Singh ◽  
Amar Taksande
Keyword(s):  
Early Detection ◽  
Diagnostic Accuracy ◽  
Screening Method ◽  
Cost Effective ◽  
Cross Sectional ◽  
Ocular Abnormalities ◽  
Red Eye ◽  
Optical Media ◽  
Ocular Abnormality ◽  
Reflection Of Light

Background: The Red Reflex is described as the red to orange reflection of light from the fundus of the eye, observed while using a retinoscope or an ophthalmoscope. Red Eye Reflex Test is determined by the optical media transparency which includes vitreous humor, aqueous humor, cornea and tear film and reflection of light from the  back of the eye (fundus) through optical media and into the aperture of the ophthalmoscope. Factors that will block or impede the passage of light through this transparent media or affects its reflection back from fundus will produce an abnormal Red Eye Reflex. Red Eye Reflex (RER) testing is important & effective tool for early detection of ocular abnormalities such as retinal abnormalities, cataract, retinoblastoma and glaucoma. Red reflex is cost effective, can be performed very easily, requires minimal setting, can screen important ocular abnormalities and facilitate their early detection with prompt intervention to prevent long term sequelae associated with the disease. Aim: To find out the diagnostic accuracy of Red Reflex test for diagnosing ocular abnormalities in newborns. Methodology: Ours will be a prospective cross-sectional study where RER examination will be performed within one week of birth of a newborn in a darkened and will correlate the examination findings with respect to ocular findings determined by ophthalmologist to determine its efficacy, sensitivity and specificity in detecting neonatal ocular abnormalities. Expected results: After completion of the study we will be able to determine the accuracy of RRT for ocular abnormality detection in the neonates. We will be able to determine the sensitivity, specificity, PPV & NPV of the red reflex test. If the specificity and the sensitivity is good then we can use RRT as a routine screening method for detection of intraocular abnormalities. Conclusion: To find the Red reflex Test efficacy in screening of the ocular abnormalities in the new born.

scholarly journals Fusogenics

2010 ◽  
Vol 16 (1) ◽  
pp. 90-100 ◽  
Author(s):  
Jeannick Cizeau ◽  
Marianne G. P. Torres ◽  
Sharla G. Cowling ◽  
Stacy Stibbard ◽  
Arjune Premsukh ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Screening Method ◽  
Antibody Fragment ◽  
Vital Role ◽  
Single Step ◽  
Functional Assay ◽  
Plant Toxin ◽  
Promising Alternative ◽  
Pseudomonas Exotoxin A ◽  
Normal Tissues

Antibody-based therapeutics play a vital role in the treatment of certain cancers; however, despite commercial success, various strategies are being pursued to increase their potency and hence improve patient outcomes. The use of antibodies to deliver a cytotoxic payload offers a promising alternative for more efficacious therapies. Immunotoxins are composed of an internalizing antibody fragment linked to a bacterial or plant toxin. Once internalized, the payload, such as Pseudomonas exotoxin A (PE), blocks protein synthesis and induces apoptosis. Typically, immunotoxins are developed by first isolating a tumor-specific antibody, which is then either chemically linked to a toxin or reengineered as a fusion protein. Here, the authors describe the development of Fusogenics, an immunotoxin-based screening method that selects internalizing tumor-specific antibodies using a functional assay. Selected immune library clones were characterized and shown to be selective against normal tissues and specific to tumor tissues. In summary, the Fusogenics immunotoxin platform represents a unique, single-step selection approach combining specificity and functionality to isolate novel internalizing tumor-specific antibody fragments with potential for direct clinical application in the treatment of cancer.

ABNORMALITIES OF THE GENITOURINARY TRACT DISCOVERED BY PALPATION OF THE ABDOMEN OF THE NEWBORN

PEDIATRICS ◽  
1956 ◽  
Vol 18 (5) ◽  
pp. 782-789
Author(s):  
David W. Sherwood ◽  
Richard C. Smith ◽  
Robert H. Lemmon ◽  
Irene Vrabel
Keyword(s):  
Gastrointestinal Tract ◽  
Early Detection ◽  
Congenital Anomalies ◽  
Newborn Infants ◽  
Genitourinary Tract ◽  
Review Of The Literature

Twenty-four cases of congenital anomalies and pathologic states of the genitourinary tract, discovered by palpation of the abdomen in newborn infants have been presented together with a review of the literature and description of the methods employed in their detection. The authors are of the opinion that deep palpation of the abdomen in newborns will reveal abnormalities, mostly of the genitourinary tract but also of the gastrointestinal tract, which are now being overlooked. It is also our belief that these pathologic conditions are most easily detected shortly after birth and that early detection is of great importance to the welfare of the patient.

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