Development of a fluorescence video endoscopy imaging system for the early detection of cancer in the gastrointestinal tract

1997 ◽  
Author(s):  
Haishan Zeng ◽  
Alan Weiss ◽  
Calum E. MacAulay ◽  
Nick MacKinnon ◽  
Richard W. Cline ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Early Detection ◽  
Early Detection Of Cancer ◽  
Imaging System ◽  
Video Endoscopy

scholarly journals Clinical Experience Using a Real Time Autofluorescence Endoscopy System in the Gastrointestinal Tract

1999 ◽  
Vol 5 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Tatsuo Ogihara ◽  
Haruo Watanabe ◽  
Akihiro Namihisa ◽  
Osamu Kobayashi ◽  
Hiroto Miwa ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Early Detection ◽  
Imaging System ◽  
Screening Method ◽  
Prototype System ◽  
Low Grade ◽  
White Light Endoscopy ◽  
Normal Tissues ◽  
Autofluorescence Endoscopy ◽  
Neoplastic Tissues

Autofluorescence spectra of neoplastic tissues have been reported to be significantly different from those of normal tissues when excited by blue or violet light. From this concept, a light-induced autofluorescence endoscopic imaging system for gastrointestinal mucosa (LIFE-GI; Xillix, Canada and Olympus, Japan) has been newly developed and the clinical evaluation of the prototype system has been conducted in hospitals in Canada, Netherlands and Japan.We examined the clinical usefulness of the prototype LIFE-GI system for the detection of gastrointestinal cancer and high and low grade dysplasia. The LIFE-GI system was also applied to the early detection of remnant lesions after endoscopic treatment of early gastric cancer and to the detection of laterally spreading superficial colonic tumors.This system has potential application for the diagnosis of dysplastic lesions and early cancers in the gastrointestinal tract as an adjunct to ordinary white light endoscopy. This system, which needs no administration of a photosensitive agent, may be suitable as a screening method for the early detection of neoplastic tissues.

Patented Biomarker Panels in Early Detection of Cancer

2011 ◽  
Vol 1 (1) ◽  
pp. 10-24 ◽  
Author(s):  
Monica Neagu ◽  
Carolina Constantin ◽  
Cristiana Tanase ◽  
Daniel Boda
Keyword(s):  
Early Detection ◽  
Early Detection Of Cancer

scholarly journals Early Detection of Cancer: Evaluation of MR Imaging Grading Systems in Patients with Suspected Nasopharyngeal Carcinoma

2020 ◽  
Vol 41 (3) ◽  
pp. 515-521 ◽  
Author(s):  
A.D. King ◽  
J.K.S. Woo ◽  
Q.-Y. Ai ◽  
F.K.F. Mo ◽  
T.Y. So ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Early Detection ◽  
Mr Imaging ◽  
Early Detection Of Cancer ◽  
Grading Systems

Early detection of cancer

1989 ◽  
Vol 5 (3) ◽  
pp. 151-152
Author(s):  
Loren J. Humphrey
Keyword(s):  
Early Detection ◽  
Early Detection Of Cancer

scholarly journals Methylation as a critical epigenetic process during tumor progressions among Iranian population: an overview

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Iman Akhlaghipour ◽  
Amir Reza Bina ◽  
Mohammad Reza Abbaszadegan ◽  
Meysam Moghbeli
Keyword(s):  
Risk Factors ◽  
Early Detection ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Early Detection Of Cancer ◽  
Iranian Population ◽  
Molecular Diagnostic ◽  
Genomic Changes ◽  
Incidence And Mortality ◽  
Transcriptional Alterations

AbstractCancer is one of the main health challenges and leading causes of deaths in the world. Various environmental and genetic risk factors are associated with tumorigenesis. Epigenetic deregulations are also important risk factors during tumor progression which are reversible transcriptional alterations without any genomic changes. Various mechanisms are involved in epigenetic regulations such as DNA methylation, chromatin modifications, and noncoding RNAs. Cancer incidence and mortality have a growing trend during last decades among Iranian population which are significantly related to the late diagnosis. Therefore, it is required to prepare efficient molecular diagnostic panels for the early detection of cancer in this population. Promoter hyper methylation is frequently observed as an inhibitory molecular mechanism in various genes associated with DNA repair, cell cycle regulation, and apoptosis during tumor progression. Since aberrant promoter methylations have critical roles in early stages of neoplastic transformations, in present review we have summarized all of the aberrant methylations which have been reported during tumor progression among Iranian cancer patients. Aberrant promoter methylations are targetable and prepare novel therapeutic options for the personalized medicine in cancer patients. This review paves the way to introduce a non-invasive methylation specific panel of diagnostic markers for the early detection of cancer among Iranians.

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