scholarly journals A Rare Metastatic Site of Invasive Lobular Breast Carcinoma: A Case Report

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Sara Husain ◽  
Mohamed Isa ◽  
Raed Almarzooq
Keyword(s):  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Linitis Plastica ◽  
Lobular Breast Cancer ◽  
Gastric Metastasis ◽  
Persistent Vomiting ◽  
Metastatic Site ◽  
Upper Gi ◽  
Upper Gi Endoscopy ◽  
Lobular Breast Carcinoma

Here, we report a case of a 42-year-old female patient with left lobular breast cancer-gastric metastasis (initially misdiagnosed five years ago as an invasive ductal carcinoma) presenting with dyspepsia, weight loss, and persistent vomiting lasting for four weeks. Upper GI endoscopy revealed evidence of linitis plastica, and histological and immunocytochemical analyses of the biopsy confirmed gastric metastasis secondary to invasive lobular breast carcinoma.

Metastases from lobular breast cancer as an unusual source of GI bleeding.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12557-e12557
Author(s):  
Emily Clarke ◽  
James George ◽  
Andrew Peter Dean
Keyword(s):  
Breast Cancer ◽  
Abdominal Pain ◽  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Gi Bleeding ◽  
Lobular Breast Cancer ◽  
Gi Tract ◽  
Invasive Ductal Breast Carcinoma ◽  
Lobular Breast Carcinoma

e12557 Background: With the exception of malignant melanoma, metastases to the GI tract are rare, especially as a first presentation of malignancy. We report a series of patients with GI metastases from lobular breast carcinoma as an unusual source of symptomatic GI bleeding. Methods: We conducted an electronic database search to identify solid tumour patients (excluding melanoma) with metastases to the GI tract. We then analysed the database by tumour type. Results: 3 cases of proven metastasis to the GI tract were identified. All had lobular breast cancer metastases. The database contained 240 patients with breast cancer, identifying 63 with infiltrating lobular carcinoma, 2 with micropapillary and 175 with invasive ductal carcinoma The 1st case had had invasive ductal breast carcinoma 6 years previously and presented with fatigue and shortness of breath from anaemia. Colonoscopy revealed a polyp which was removed. Histopathology showed metastatic lobular breast carcinoma. Further investigation then confirmed an occult breast mass with identical pathology. The 2nd case presented with 18 months of abdominal pain, previous colonoscopy was normal. After onset of anaemia and 25kg weight loss, upper GI endoscopy showed a markedly thickened stomach with evidence of recent bleeding and biopsies confirmed metastatic lobular breast carcinoma. The 3rd case presented with abdominal pain, subsequent blood tests showing a raised CA125 with omental and ovarian masses. Surgical debulking showed metastatic lobular breast carcinoma, though no primary breast lesion was detectable with mammography, ultrasound and MRI. 3 years later, investigation of anaemia with colonoscopy showed a caecal polyp with histology confirming lobular breast carcinoma. Conclusions: Despite all common tumour types being represented in the database it is notable that all 3 cases with mucosal GI metastases had lobular breast cancer. Previous evidence suggests a long latent period from initial diagnosis of breast cancer to development of GI metastases however our report suggests it can occur earlier in the illness. Clinicians should consider this as a rare cause of GI bleeding and further research to understand the mechanism of mucosal metastasis in lobular breast cancer is needed.

Gastric metastasis before diagnosis of primary invasive lobular breast carcinoma: a rare case presentation from Pakistan

2021 ◽  
pp. 1-5
Author(s):  
Mashhood Ali ◽  
Shahid Aziz ◽  
Imran Ahmad ◽  
Aiza Saadia ◽  
Rabaab Zahra ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Rare Case ◽  
Gastric Metastasis ◽  
Case Presentation ◽  
Lobular Breast Carcinoma

scholarly journals S3604 Gastric Metastasis of Invasive Lobular Breast Carcinoma

2020 ◽  
Vol 115 (1) ◽  
pp. S1860-S1861
Author(s):  
Pratik Patel ◽  
Adrian Pona ◽  
Deepak Donthi ◽  
Areeba H. Rizvi
Keyword(s):  
Breast Carcinoma ◽  
Gastric Metastasis ◽  
Lobular Breast Carcinoma

scholarly journals UPPER GI ENDOSCOPY

2014 ◽  
Vol 21 (03) ◽  
pp. 460-464
Author(s):  
Muhammad Zakria ◽  
Awais Shuja
Keyword(s):  
Epigastric Pain ◽  
University Hospital ◽  
Persistent Vomiting ◽  
Gi Endoscopy ◽  
Endoscopic Findings ◽  
Upper Gi ◽  
Endoscopy Unit ◽  
Unit Design ◽  
Upper Gi Endoscopy ◽  
Independent University

Objective: To document various endoscopic findings in patients undergoingupper GI endoscopy in our endoscopy unit. Design: Observational. Patients and methods: Thedata of 100 patients who underwent upper GI endoscopy in Endoscopy Unit of IndependentMedical College/ Independent University Hospital from April 2010 to December 2012 wasanalyzed. Demographic features, reasons for referral and endoscopic diagnoses were noted.Results: Among 100 patients, 35% were referred due to persistent vomiting, 28% due toepigastric pain / discomfort, 18 % due to dyspepsia and 7% due to retrosternal burning and uppergastrointestinal bleeding. Common endoscopic diagnoses were gastritis (28%), duodenitis(14%), gastroesophageal reflux disease / esophagitis (6%), esophageal varices (5%) andesophageal growth (4%). Conclusions: The most common presenting complaint was persistentvomiting followed by epigastric pain / discomfort and the most common endoscopic finding wasgastritis.

Gastric metastasis resembling linitis plastica 17 years after lobular breast cancer

2020 ◽  
Vol 52 (2) ◽  
pp. 232
Author(s):  
Yasuhiko Hamada ◽  
Kyosuke Tanaka ◽  
Aiji Hattori ◽  
Toshiro Mizuno
Keyword(s):  
Breast Cancer ◽  
Linitis Plastica ◽  
Lobular Breast Cancer ◽  
Gastric Metastasis

scholarly journals Diarrhoea Caused by Diffuse Metastatic Lobular Breast Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Sjoerd F. Bakker ◽  
Willem Moolenaar ◽  
Marije M. van Santen ◽  
Mathijs P. Hendriks
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Gastrointestinal Symptoms ◽  
Laboratory Research ◽  
Ascending Colon ◽  
Lobular Breast Cancer ◽  
The Past ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Descending Colon

A 70-year-old woman with a history of lobular breast cancer presented to our Outpatient Clinic with diarrhoea for the past 3 years. Clinical examination and laboratory research were normal. Colonoscopy showed diffuse mild erythema and a decreased vascular pattern. Biopsies from the ascending colon, transverse colon, and descending colon showed metastases of lobular breast carcinoma. Although gastrointestinal metastases are rare in breast cancer, our case emphasizes the need for further diagnostic efforts in patients with gastrointestinal symptoms and a history of breast carcinoma.

Gastric Metastasis in a Patient with Lobular Breast Carcinoma 6 Years After Diagnosis

2014 ◽  
Vol 45 (4) ◽  
pp. 504-505
Author(s):  
Orhan Onder Eren ◽  
Mehmet Akif Ozturk ◽  
Ozlem Sonmez ◽  
Ekrem Aslan ◽  
Ferda Ozkan ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Gastric Metastasis ◽  
Lobular Breast Carcinoma

scholarly journals A84 LINITIS PLASTICA FROM A NON-GASTROINTESTINAL PRIMARY TUMOR: A CASE REPORT

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 98-99
Author(s):  
J Ghaith ◽  
I Alhafid ◽  
F Habal
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Breast Carcinoma ◽  
Complete Blood Count ◽  
Gastric Wall ◽  
Linitis Plastica ◽  
Clinical Syndrome ◽  
Screening Tests ◽  
Lobular Breast Cancer ◽  
Diagnostic Features

Abstract Background Infiltrative malignancies to the stomach are unusual and are difficult to detect. Linitis Plastic is a syndrome caused by submucosal invasion of the gastric wall. It represents Bormann type III or IV of gastric adenocarcinoma. Uncommonly, the latter can be a manifestation of lobular breast cancer. Aims To present a case report of lobular breast cancer that manifested primarily as Linitis Plastica (LP). We review the literature of LP as a clinical syndrome and the diagnostic challenges associated with this condition. We aim to increase the awareness of LP as a non-gastric tumor and its endoscopic features. Methods - Results A seventy-two-year-old female patient, previously healthy, presented with general deconditioning and distended abdomen. Basic laboratory testing such as complete blood count, electrolytes and kidney function were normal. Computed tomography of the abdomen and pelvis revealed moderately sized peritoneal carcinomatosis deposits on the abdominal wall. Her family history was non-contributary for any gastrointestinal or gynecological malignancies. On review of system, the patient noted a history of successful eradication of Helicobacter pylori infection remotely. Additionally, no preceding age-appropriate malignancy screening tests were reported. A gastroscopy was done looking for a primary gastrointestinal tumor exhibited abnormally stiff gastric wall, erythematous thickened mucosal folds, and non-distensible stomach. No clear lesions, submucosal masses or ulcers were visualized. The duodenal mucosa was noted to be normal. Twelve deep random biopsies were retrieved from the mucosal body and fundus. Following immunohistochemistry, the histological diagnosis revealed lobular adenocarcinoma of the breast. Conclusions Linitis Plastica (leather bottle stomach) or Brinton disease is a rare entity of diffuse gastric mucosa infiltrating tumor. LP depicts 3–10% of primary gastric carcinoma, whilst less than 10% are secondary breast cancer. Endoscopically, breast cancer-related LP can be divided into two morphologies: nodular pattern with ulceration, which is the typical presentation of ductal breast carcinoma and diffuse mural pattern in lobular breast carcinoma. LP is a unique condition with challenging diagnostic features. Many biopsies can result in negative histopathological diagnoses. This can be explained partially by 1. The scirrhous and fibrous stroma that forms LP tumors. 2. The deep location in the submucosa and muscular layer of the gastric wall. 3. Inability to identify this entity endoscopically. In one case report, Endoscopic Ultrasound-Fine Needle Aspirate (EUS-FNA) was incorporated after negative obtained biopsies. There are no standardized diagnostic approaches for LP. Further studies inquiring rates of missed malignant diagnoses and optimum diagnostic assessments in the setting of LP are needed. Funding Agencies None

Sign in / Sign up

Export Citation Format

Share Document