scholarly journals Diarrhoea Caused by Diffuse Metastatic Lobular Breast Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Sjoerd F. Bakker ◽  
Willem Moolenaar ◽  
Marije M. van Santen ◽  
Mathijs P. Hendriks
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Gastrointestinal Symptoms ◽  
Laboratory Research ◽  
Ascending Colon ◽  
Lobular Breast Cancer ◽  
The Past ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Descending Colon

A 70-year-old woman with a history of lobular breast cancer presented to our Outpatient Clinic with diarrhoea for the past 3 years. Clinical examination and laboratory research were normal. Colonoscopy showed diffuse mild erythema and a decreased vascular pattern. Biopsies from the ascending colon, transverse colon, and descending colon showed metastases of lobular breast carcinoma. Although gastrointestinal metastases are rare in breast cancer, our case emphasizes the need for further diagnostic efforts in patients with gastrointestinal symptoms and a history of breast carcinoma.

Metastases from lobular breast cancer as an unusual source of GI bleeding.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12557-e12557
Author(s):  
Emily Clarke ◽  
James George ◽  
Andrew Peter Dean
Keyword(s):  
Breast Cancer ◽  
Abdominal Pain ◽  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Gi Bleeding ◽  
Lobular Breast Cancer ◽  
Gi Tract ◽  
Invasive Ductal Breast Carcinoma ◽  
Lobular Breast Carcinoma

e12557 Background: With the exception of malignant melanoma, metastases to the GI tract are rare, especially as a first presentation of malignancy. We report a series of patients with GI metastases from lobular breast carcinoma as an unusual source of symptomatic GI bleeding. Methods: We conducted an electronic database search to identify solid tumour patients (excluding melanoma) with metastases to the GI tract. We then analysed the database by tumour type. Results: 3 cases of proven metastasis to the GI tract were identified. All had lobular breast cancer metastases. The database contained 240 patients with breast cancer, identifying 63 with infiltrating lobular carcinoma, 2 with micropapillary and 175 with invasive ductal carcinoma The 1st case had had invasive ductal breast carcinoma 6 years previously and presented with fatigue and shortness of breath from anaemia. Colonoscopy revealed a polyp which was removed. Histopathology showed metastatic lobular breast carcinoma. Further investigation then confirmed an occult breast mass with identical pathology. The 2nd case presented with 18 months of abdominal pain, previous colonoscopy was normal. After onset of anaemia and 25kg weight loss, upper GI endoscopy showed a markedly thickened stomach with evidence of recent bleeding and biopsies confirmed metastatic lobular breast carcinoma. The 3rd case presented with abdominal pain, subsequent blood tests showing a raised CA125 with omental and ovarian masses. Surgical debulking showed metastatic lobular breast carcinoma, though no primary breast lesion was detectable with mammography, ultrasound and MRI. 3 years later, investigation of anaemia with colonoscopy showed a caecal polyp with histology confirming lobular breast carcinoma. Conclusions: Despite all common tumour types being represented in the database it is notable that all 3 cases with mucosal GI metastases had lobular breast cancer. Previous evidence suggests a long latent period from initial diagnosis of breast cancer to development of GI metastases however our report suggests it can occur earlier in the illness. Clinicians should consider this as a rare cause of GI bleeding and further research to understand the mechanism of mucosal metastasis in lobular breast cancer is needed.

scholarly journals Metastatic Lobular Breast Cancer Mimicking Colitis

Reports ◽  
2020 ◽  
Vol 3 (3) ◽  
pp. 20
Author(s):  
Renata Reis Figueiredo ◽  
Tatiana Strava Correa ◽  
Carlos Henrique dos Anjos ◽  
Heinrich Bender Kohnert Seidler
Keyword(s):  
Breast Cancer ◽  
Germline Mutation ◽  
Lobular Carcinoma ◽  
Progesterone Receptors ◽  
Pathological Examination ◽  
Lobular Breast Cancer ◽  
Paternal Uncle ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Invasive Breast Carcinomas

Breast cancer is the most frequent cancer diagnosed in women in the world regardless of race or ethnicity. About 10% of invasive breast carcinomas are lobular subtype. The loss of the E-caderin expression that occurs in lobular carcinoma leads to a higher risk of metastases in membranes (meningeal, pleural, peritoneum) and gastrointestinal and/or endobronchial mucous, which may lead to several odd symptomatology. We report a 79 years old female patient with lobular breast cancer associated to CDH1 germline mutation. She was diagnosed with breast cancer in December 2016 after noticing a right-armpit nodule whose pathological examination demonstrated an immunohistochemistry profile compatible with lobular breast carcinoma metastasis and had estrogen receptors 98%, progesterone receptors < 1%, ki67 25%, negative her2 score. Family history of only one paternal uncle with stomach cancer. After two lines of hormone therapy, she had disease progression and started oral chemotherapy with capecitabine. In a few weeks, the patient had refractory diarrhea. At the beginning, it was defined like colitis chemotherapy related. However, the clinical features showed necessity of further investigation. Then, she was diagnosed with CDH1 germline mutation after massive progression at gastrointestinal mucous. This case made possible to inform the family about risk of germline mutation and necessity of genetic counseling.

scholarly journals A Rare Metastatic Site of Invasive Lobular Breast Carcinoma: A Case Report

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Sara Husain ◽  
Mohamed Isa ◽  
Raed Almarzooq
Keyword(s):  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Linitis Plastica ◽  
Lobular Breast Cancer ◽  
Gastric Metastasis ◽  
Persistent Vomiting ◽  
Metastatic Site ◽  
Upper Gi ◽  
Upper Gi Endoscopy ◽  
Lobular Breast Carcinoma

Here, we report a case of a 42-year-old female patient with left lobular breast cancer-gastric metastasis (initially misdiagnosed five years ago as an invasive ductal carcinoma) presenting with dyspepsia, weight loss, and persistent vomiting lasting for four weeks. Upper GI endoscopy revealed evidence of linitis plastica, and histological and immunocytochemical analyses of the biopsy confirmed gastric metastasis secondary to invasive lobular breast carcinoma.

scholarly journals Spontaneous regression of breast carcinoma: review of English publications from 1753 to 1897

2012 ◽  
Vol 6 (2) ◽  
pp. 22 ◽  
Author(s):  
Wilson I.B. Onuigbo
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Spontaneous Regression ◽  
Current Knowledge ◽  
English Literature ◽  
Important Phenomenon ◽  
History Of ◽  
Historical Accounts ◽  
History Of Cancer ◽  
Cancer Regression

Regression is an important phenomenon in oncology. Two reviews in 2011 dealt at length with what in modern parlance may be called its permutations and combinations. Specifically, in both 1982 and 1987, when its occurrence in breast cancer was presented from two centers, the oldest accounts of it were dated back to 1900. Therefore, a search for much older English literature was undertaken in order to widen current knowledge of this important problem. Consequently, a published long case dating back to 1897 is abridged and a short 1846 case is also noted. Furthermore, general etiological concepts are exemplified as far back as 1753. It is concluded that the history of cancer regression is like fishing in an ocean of this illness. However, the findings are deemed to complement what modern historical accounts lack.

scholarly journals Lobular breast carcinoma metastatic to the endometrium in a patient under tamoxifen therapy: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2090720
Author(s):  
Mariangela Gomez ◽  
Kerry Whitting ◽  
Rana Naous
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Radical Mastectomy ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Tamoxifen Therapy ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Post Menopausal ◽  
Rule Out

Metastatic carcinomas to the uterus are rare and usually originate from nearby gynecologic sites, most commonly from the ovaries. Among non-gynecologic origins, breast tumors are the most frequent primaries, predominantly the lobular carcinoma type. A 69-year-old postmenopausal woman diagnosed with lobular breast carcinoma 5 years ago, status post modified radical mastectomy, and currently on tamoxifen therapy presented with post-menopausal bleeding. Subsequent endometrial biopsy confirmed the diagnosis of metastatic lobular breast carcinoma to the endometrium. Breast carcinomas rarely metastasize to the uterus, especially lobular carcinoma type. Abnormal uterine bleeding in a patient with known history of breast carcinoma and under tamoxifen therapy should prompt a complete diagnostic workup to rule out metastatic disease.

Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect

2018 ◽  
Vol 55 (7) ◽  
pp. 431-441 ◽  
Author(s):  
Giovanni Corso ◽  
Joana Figueiredo ◽  
Carlo La Vecchia ◽  
Paolo Veronesi ◽  
Gabriella Pravettoni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Age At Onset ◽  
Genetic Defect ◽  
Prophylactic Surgery ◽  
Current Evidence ◽  
Diffuse Gastric Cancer ◽  
Lobular Breast Cancer ◽  
Clinicopathological Findings ◽  
History Of

Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer (LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A multidisciplinary workgroup discussed genetic susceptibility, pathophysiology and clinical management of hereditary LBC (HLBC). The team has established the clinical criteria for CDH1 screening and results’ interpretation, and created consensus guidelines regarding genetic counselling, breast surveillance and imaging techniques, clinicopathological findings, psychological and decisional support, as well as prophylactic surgery and plastic reconstruction. Based on a review of current evidence for the identification of HLBC cases/families, CDH1 genetic testing is recommended in patients fulfilling the following criteria: (A) bilateral LBC with or without family history of LBC, with age at onset <50 years, and (B) unilateral LBC with family history of LBC, with age at onset <45 years. In CDH1 asymptomatic mutant carriers, breast surveillance with clinical examination, yearly mammography, contrast-enhanced breast MRI and breast ultrasonography (US) with 6-month interval between the US and the MRI should be implemented as a first approach. In selected cases with personal history, family history of LBC and CDH1 mutations, prophylactic mastectomy could be discussed with an integrative group of clinical experts. Psychodecisional support also plays a pivotal role in the management of individuals with or without CDH1 germline alterations. Ultimately, the definition of a specific protocol for CDH1 genetic screening and ongoing coordinated management of patients with HLBC is crucial for the effective surveillance and early detection of LBC.

The Uses and Abuses of the Past

Worldview ◽  
1974 ◽  
Vol 17 (8) ◽  
pp. 45-50
Author(s):  
John P. Sisk
Keyword(s):  
Breast Cancer ◽  
Depth Psychology ◽  
Chief Executive ◽  
Causative Factor ◽  
Doctor Who ◽  
German Culture ◽  
History Of Childhood ◽  
The Past ◽  
History Of ◽  
The Subject

Recently I received in the mail an advertising brochure for the History of Childhood Quarterly, a publication committed to the assumptions and objectives of psychohistory. I read psychohistory before I knew there was such a thing, particularly in the fascinating studies of Luther and Gandhi by Erik Erickson, and certainly before I was aware that the subject was such a controversial one among historians, who are perhaps now wondering: Do the insights of depth psychology reveal hitherto hidden causes of historic events, or do they represent a dangerous intrusion of a discipline that is imprecise enough when working with living subjects, let alone long dead ones? Was the Jewish doctor who poisoned Hitler's mother while operating on her for breast cancer a causative factor in Hitler's later decision to remove the Jewish cancer from German culture? Was Nixon's vi gorous prosecution of the war in Vietnam connected with his childhood worries about being a sissy? Was President John F. Kennedy affected as Chief Executive by his unconscious belief that his parents didn't really love him?

scholarly journals Metastasis of Breast Lobular Carcinoma to Endometrium Presenting as Recurrent Abnormal Uterine Bleeding: A Case Report and Review of Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Rodolfo Franco-Márquez ◽  
Adrián Gerardo Torres-Gaytán ◽  
Marcela Anahí Narro-Martinez ◽  
Anahí Carrasco-Chapa ◽  
Benjamín Gómez Núñez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Review Of Literature ◽  
Lobular Breast Carcinoma

There are few reports of breast cancer cases with uterine metastases. Here, we report a metastatic lobular carcinoma to endometrium presenting as abnormal uterine bleeding. Diagnosis was based in previous lobular breast carcinoma and immunohistochemistry.

scholarly journals Excision of metastatic breast cancer from sternum and reconstruction in two patients with solitary metastatic spread

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Saifullah Mohamed ◽  
Khurum Mazhar ◽  
Ahmed Osman ◽  
Akshay Patel ◽  
Lakshmi Srinivasan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Previous History ◽  
Metastatic Breast ◽  
Extent Of Resection ◽  
Left Breast ◽  
Term Survival ◽  
Metastatic Breast Carcinoma ◽  
History Of ◽  
Treated Breast

Abstract Metastatic breast carcinoma is a relatively common clinical entity. However, the prognosis of oligometastatic and polygometastatic disease differs considerably pertaining to five-year survival. Metastatic breast carcinoma to the sternum has been described as early as 1988. We describe two cases in our institution who presented with solitary sternal metastases with a previous history of treated breast cancer. In both cases, there had been a history of previous left breast cancer treated aggressively with surgical resection and adjuvant oncological therapy and maintenance hormonal therapy. Partial sternectomy or total sternectomy for solitary metastatic sternal deposits is well established with relatively low morbidity and mortality and improvement in quality of life and possible improvement in long-term survival. Furthermore, reconstructive options are inherently dependent on extent of resection performed. These techniques can incorporate the use of sternal plates in order to approximate defects and reinforce the sternum in the setting of partial sternectomy.

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