scholarly journals Bioactive Compounds in Infant Formula and Their Effects on Infant Nutrition and Health: A Systematic Literature Review

2021 ◽  
Vol 2021 ◽  
pp. 1-31
Author(s):  
Cristine Couto Almeida ◽  
Bianca Figueiredo Mendonça Pereira ◽  
Katia Christina Leandro ◽  
Marion Pereira Costa ◽  
Bernardete Ferraz Spisso ◽  
...  
Keyword(s):  
Literature Review ◽  
Human Milk ◽  
Infant Formula ◽  
Bioactive Compounds ◽  
Systematic Literature Review ◽  
Infant Nutrition ◽  
Infant Formulas ◽  
Nutrition And Health ◽  
Bioactive Ingredients ◽  
Formula Composition

Infant formulas are an alternative to replace or supplement human milk when breastfeeding is not possible. The knowledge of human milk’s bioactive compounds and their beneficial effects has attracted the interest of researchers in the field of infant nutrition, as well as researchers of technology and food sciences that seek to improve the nutritional characteristics of infant formulas. Several scientific studies evaluate the optimization of infant formula composition. The bioactive compound inclusion has been used to upgrade the quality and nutrition of infant formulas. In this context, the purpose of this systematic literature review is to assess the scientific evidence of bioactive compounds present in infant formulas (α-lactalbumin, lactoferrin, taurine, milk fat globule membrane, folates, polyamines, long-chain polyunsaturated fatty acids, prebiotics, and probiotics) and their effects on infant nutrition and health. Through previously determined criteria, studies published in the last fifteen years from five different databases were included to identify the advances in the optimization of infant formula composition. Over the last few years, there has been optimization of the infant formula composition, not only to increase the similarities in their content of macro and micronutrients but also to include novel bioactive ingredients with potential health benefits for infants. Although the infant food industry has advanced in the last years, there is no consensus on whether novel bioactive ingredients added to infant formulas have the same functional effects as the compounds found in human milk. Thus, further studies about the impact of bioactive compounds in infant nutrition are fundamental to infant health.

Differences in Vitamin E and C Profile Between Infant Formula and Human Milk and Relative Susceptibility to Lipid Oxidation

2013 ◽  
Vol 83 (5) ◽  
pp. 311-319 ◽  
Author(s):  
Ingrid Elisia ◽  
David D. Kitts
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Vitamin C ◽  
Human Milk ◽  
Lipid Oxidation ◽  
Infant Formula ◽  
Milk Formula ◽  
Infant Formulas ◽  
Vitamin E And C ◽  
Vit C

The vitamin E isoforms and vitamin (vit) C content of infant formulas were compared to human milk and related to relative susceptibilities to lipid peroxidation. We report that a highly distinct vitamin E and C profile exists between formula and human milk. Whileα-tocopherol (α-Toc) is the dominant vit E isoform in human milk, formula contains a substantial amount of α-Toc and δ-Toc that was greater than the level found in human milk (12- and 32-fold, respectively). Vitamin C was also two- fold higher in infant formula compared to human milk. Despite the higher vitamin E and C content, we also observed higher rates of lipid oxidation in the formula when compared to human milk. Storing human milk for one day at refrigeration temperatures did not produce hexanal in human milk, but this storage resulted in an increase in hexanal in formulas. We conclude that the higher concentrations of γ-Toc and δ-Toc in infant formulas did not provide similar protection from lipid oxidation as human milk. We also observed that vit C content was reduced during storage in both infant formula and human milk, which did not occur with the Toc isoforms.

Current Methods for the Analysis of Selected Novel Nutrients in Infant Formulas and Adult Nutritionals

2016 ◽  
Vol 99 (1) ◽  
pp. 30-41 ◽  
Author(s):  
Brendon D Gill ◽  
Harvey E Indyk ◽  
David C Woollard
Keyword(s):  
Sialic Acid ◽  
Breast Milk ◽  
Infant Formula ◽  
Analytical Methods ◽  
Infant Nutrition ◽  
Sole Source ◽  
Human Infant ◽  
Infant Formulas ◽  
Representative Selection

Abstract Infant formula is designed to provide the human infant with a sole source of nutrition and it is intended to imitate breast milk. In recent years, advances in the science of infant nutrition have led to an increasing number of novel ingredients that are supplemented into infant formula. As the list of these nutritionally important nutrients is lengthy, this review summarizes contemporary analytical methods that have been applied to a representative selection (lutein, carnitine, choline, nucleotides, inositol, taurine, sialic acid, gangliosides, triacylglycerides, oligosaccharides, α-lactalbumin, and lactoferrin).

scholarly journals A Validated Method for Detection and Quantitation of 2’Fucosyllactose in Infant Formula Matrices

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Pedro A. Prieto ◽  
Michael B. Miklus ◽  
Cynthia M. Barber ◽  
Steven M. Tennyson
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Limit Of Detection ◽  
Soluble Carbohydrates ◽  
Infant Formulas ◽  
Chromatography Method ◽  
Elution Time ◽  
Potential Health ◽  
Main Challenge ◽  
Limit Of Quantitation

Analytical methods to assess the content of free carbohydrates in solution range from simple tests of reductive power to combinations of chromatography and mass spectrometry. Soluble carbohydrates such as lactose, maltose, fructooligosaccharides, and galactooligosaccharides are commonly found in infant formulas either as sources of energy or soluble fibers. On the other hand, a rich repertoire of lactose-based carbohydrates occurs naturally in human milk.  The advent of novel biosynthesis technologies resulted in the availability of human milk oligosaccharide structures that are being used as ingredients in infant formulas.   Notably, 2’Fucosyllactose has been tested in preclinical and clinical studies to determine its safety and to explore its potential health benefits in the context of pediatric nutrition. Several chromatographic methods for the analysis of human milk oligosaccharides have been published and, the main challenge associated with 2’Fucosyllactose quantitation has been to improve its resolution from lactose, which is present at concentrations around 70 g/l in both, infant formula and human milk. We developed a high-performance anion exchange chromatography method to detect and quantify 2’ Fucosyllactose in the presence of lactose by expanding the elution time between these saccharides. We validated the analytical procedure which behaved linearly (average R=0.99951) at concentrations as low as 1.75 µg/ml (limit of quantitation) with an average limit of detection of 0.43 µg/ml.

scholarly journals Compositional and Functional Considerations for Bovine-, Caprine- and Plant-Based Infant Formulas

Dairy ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 695-715
Author(s):  
Margaret E. Byrne ◽  
James A. O’Mahony ◽  
Tom F. O’Callaghan
Keyword(s):  
Infant Formula ◽  
Bovine Milk ◽  
Detailed Examination ◽  
Nutritional Requirements ◽  
Protein Functionality ◽  
Infant Formulas ◽  
Rice Protein ◽  
Protein Sources ◽  
Caprine Milk ◽  
Bioactive Ingredients

Breastmilk is the optimal source of nutrition for infants. However, in circumstances where breastfeeding is not possible or feasible, infant formula provides an essential alternative to fulfil the nutritional requirements of the developing infant. Traditionally, the manufacture of infant formula has involved utilisation of bovine milk as a base ingredient, formulated with other nutrients and bioactive ingredients to closely match the composition of human breastmilk. While it is the most widely available type of formula on the market, bovine-based infant formula is not suitable for all infants, and therefore alternatives such as those based on caprine milk, soy and rice protein are becoming increasingly available. This review provides a detailed examination of the composition of infant formula prepared from bovine milk, caprine milk, soy, and rice protein sources. Available literature on nutrient bio-accessibility and aspects of protein functionality relevant to infant formula is discussed.

Phospholipids in Human Milk and Infant Formulas: Benefits and Needs for Correct Infant Nutrition

2015 ◽  
Vol 56 (11) ◽  
pp. 1880-1892 ◽  
Author(s):  
Antonio Cilla ◽  
Késia Diego Quintaes ◽  
Reyes Barberá ◽  
Amparo Alegría
Keyword(s):  
Human Milk ◽  
Infant Nutrition ◽  
Infant Formulas

scholarly journals Effects of infant formula composition on long-term metabolic health

2018 ◽  
Vol 9 (6) ◽  
pp. 573-589 ◽  
Author(s):  
M. Lemaire ◽  
I. Le Huërou-Luron ◽  
S. Blat
Keyword(s):  
Gut Microbiota ◽  
Infant Formula ◽  
Gold Standard ◽  
Metabolic Health ◽  
Infant Formulas ◽  
Lipid Matrix ◽  
Early Nutrition ◽  
Formula Composition ◽  
Host Metabolism

Early nutrition may have long-lasting metabolic impacts in adulthood. Even though breast milk is the gold standard, most infants are at least partly formula-fed. Despite obvious improvements, infant formulas remain perfectible to reduce the gap between breastfed and formula-fed infants. Improvements such as reducing the protein content, modulating the lipid matrix and adding prebiotics, probiotics and synbiotics, are discussed regarding metabolic health. Numerous questions remain to be answered on how impacting the infant formula composition may modulate the host metabolism and exert long-term benefits. Interactions between early nutrition (composition of human milk and infant formula) and the gut microbiota profile, as well as mechanisms connecting gut microbiota to metabolic health, are highlighted. Gut microbiota stands as a key actor in the nutritional programming but additional well-designed longitudinal human studies are needed.

scholarly journals Comparison of the Bifidogenic Effects of Goat and Cow Milk-Based Infant Formulas to Human Breast Milk in an in vitro Gut Model for 3-Month-Old Infants

2020 ◽  
Vol 7 ◽  
Author(s):  
Sophie Gallier ◽  
Pieter Van den Abbeele ◽  
Colin Prosser
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Goat Milk ◽  
Cow Milk ◽  
Common Source ◽  
Human Breast Milk ◽  
Infant Formulas ◽  
Infant Gut Microbiome

Human milk contains prebiotic components, such as human milk oligosaccharides (HMOs), which stimulate the growth of specific members of the infant gut microbiota (e.g., Bifidobacteria). Plant-based or synthetic oligosaccharides are often added to infant formulas to simulate the bifidogenic effect of HMOs. Cow milk, the most common source of protein in infant formula, and goat milk, used increasingly in the manufacture of infant formula, contain naturally-occurring prebiotics. This study compared the upper gastrointestinal digestion and subsequent colonic fermentation of human milk vs. goat and cow milk-based infant formulas (goat IF and cow IF, respectively), without additional oligosaccharides using an in vitro model for 3-month-old infants based on the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®). First, a dialysis approach using 3.5 kDa membranes was demonstrated to simulate small intestinal absorption of carbohydrates in conditions similar to those in vivo. During the in vitro digestion experiment, oligosaccharides were detected in human milk and goat IF but barely detected in the cow IF. Further, all three milk matrices decreased colonic pH by boosting acetate, lactate, and propionate production, which related to increased abundances of acetate/lactate-producing Bifidobacteriaceae for human milk (+25.7%) and especially goat IF (33.8%) and cow IF (37.7%). Only cow IF stimulated butyrate production which correlated with an increase in Lachnospiraceae and Clostridiaceae. Finally, Enterobacteriaceae and Acidaminococcaceae also increased with all three milk matrices, while production of proteolytic metabolites (branched-chain fatty acids) was only detected for the cow IF. Overall, goat and cow milk-based formulas without added oligosaccharides impacted gut microbial activity and composition similarly to human milk. This suggests that even without supplementation of formula with oligosaccharides, whole goat milk, whole cow milk and cow milk ingredients already supply compounds in formulas that exert beneficial bifidogenic effects. Further clinical research is warranted to elucidate the effect of whole goat milk-based formulas on the infant gut microbiome.

scholarly journals Potential Applications of Endo-β-N-Acetylglucosaminidases From Bifidobacterium longum Subspecies infantis in Designing Value-Added, Next-Generation Infant Formulas

2021 ◽  
Vol 8 ◽  
Author(s):  
Hatice Duman ◽  
Merve Kaplan ◽  
Ayşenur Arslan ◽  
Arif Sercan Sahutoglu ◽  
Haci Mehmet Kayili ◽  
...  
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Infant Nutrition ◽  
Bifidobacterium Longum ◽  
Value Added ◽  
Structural Similarity ◽  
Next Generation ◽  
Human Milk Oligosaccharides ◽  
Potential Applications ◽  
Bifidobacterium Longum Subspecies Infantis

Human milk is the optimal source of infant nutrition. Among many other health benefits, human milk can stimulate the development of a Bifidobacterium-rich microbiome through human milk oligosaccharides (HMOs). In recent years, the development of novel formulas has placed particular focus on incorporating some of the beneficial functional properties of human milk. These include adding specific glycans aimed to selectively stimulate the growth of Bifidobacterium. However, the bifidogenicity of human milk remains unparalleled. Dietary N-glycans are carbohydrate structures conjugated to a wide variety of glycoproteins. These glycans have a remarkable structural similarity to HMOs and, when released, show a strong bifidogenic effect. This review discusses the biocatalytic potential of the endo-β-N-acetylglucosaminidase enzyme (EndoBI-1) from Bifidobacterium longum subspecies infantis (B. infantis), in releasing N-glycans inherently present in infant formula as means to increase the bifidogenicity of infant formula. Finally, the potential implications for protein deglycosylation with EndoBI-1 in the development of value added, next-generation formulas are discussed from a technical perspective.

Human milk and infant formula modulate intestinal microbiota and immune system of human microbiota-associated mice

2021 ◽  
Author(s):  
Na Li ◽  
Qing gang Xie ◽  
Lina Zhao ◽  
Jialu Shi ◽  
Evivie Etareri Smith ◽  
...  
Keyword(s):  
Immune System ◽  
Breast Milk ◽  
Human Milk ◽  
Infant Formula ◽  
Intestinal Microbiota ◽  
Exclusive Breastfeeding ◽  
Infant Formulas ◽  
Human Microbiota

Many infants on exclusive breastfeeding regimen are often fed inadequate amounts, and this creates an imbalance between the overall effects of breast milk and commercial infant formulas. We comparatively analyzed...

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