Human milk and infant formula modulate intestinal microbiota and immune system of human microbiota-associated mice

2021 ◽  
Author(s):  
Na Li ◽  
Qing gang Xie ◽  
Lina Zhao ◽  
Jialu Shi ◽  
Evivie Etareri Smith ◽  
...  
Keyword(s):  
Immune System ◽  
Breast Milk ◽  
Human Milk ◽  
Infant Formula ◽  
Intestinal Microbiota ◽  
Exclusive Breastfeeding ◽  
Infant Formulas ◽  
Human Microbiota

Many infants on exclusive breastfeeding regimen are often fed inadequate amounts, and this creates an imbalance between the overall effects of breast milk and commercial infant formulas. We comparatively analyzed...

Gastroduodenal Motility in Neonates: Response to Human Milk Compared With Cow's Milk Formula

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 434-438
Author(s):  
T. Tomomasa ◽  
P. E. Hyman ◽  
K. Itoh ◽  
J. Y. Hsu ◽  
T. Koizumi ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Infant Formula ◽  
High Amplitude ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Wave Form ◽  
Fasting State ◽  
Cow's Milk ◽  
Gastroduodenal Motility

It is known that breast milk empties more quickly from the stomach than does infant formula. We studied the difference in gastroduodenal motility between neonates fed with human milk and those fed with infant formula. Twenty-four five-to 36-day-old neonates were fed with mother's breast milk or with a cow's milk-based formula. Postprandlial gastroduodenal contractions were recorded manometrically for three hours. Repetitive, high-amplitude nonmigrating contractions were the dominant wave form during the postprandial period. The number of episodes, duration, amplitude, and frequency of nonmigrating contractions were not different following the different feedings. The migrating myoelectric complex, which signals a return to the interdigestive (fasting) state, appeared in 75% of breast milk-fed infants but only 17% of formula-fed infants (P < .05) within the three-hour recording period. Because contractions were similar following the two meals, but a fasting state recurred more rapidly in breast-fed infants, we conclude that factors other than phasic, nonpropagated antroduodenal contractions were responsible for the differences in gastric emptying between breast milk and formula.

scholarly journals Amine variations in faecal content in the first weeks of life of newborns in relation to breast-feeding or infant formulas

2019 ◽  
Vol 122 (10) ◽  
pp. 1130-1141
Author(s):  
Lorena Suárez ◽  
María Moreno-Luque ◽  
Irene Martínez-Ardines ◽  
Nereida González ◽  
Patricia Campo ◽  
...  
Keyword(s):  
Breast Milk ◽  
Infant Formula ◽  
Breast Feeding ◽  
Intervention Studies ◽  
Caucasian Woman ◽  
Infant Formulas ◽  
Individual Variations ◽  
Feeding Type ◽  
Polyamine Content ◽  
The Ideal

AbstractBreast-feeding is the ideal nutrition for a newborn’s integral necessities. It seems crucial therefore to know its composition in order to provide suitable infant formula when required. Of these, polyamines (with lactation and the microbiota being its intestinal source) are involved in the development of gut epithelium and immunity. Safety concerns limit human intervention studies. Therefore, we studied the amounts of polyamines supplied by breast milk (varying among mothers) or infant formula feeding, up to day 30 postpartum, in the faeces of newborns. Independent samples (68) of breast milk from fifty-nine healthy Caucasian woman (day 0, 1, 3, 5, 7, 15 and 30 postpartum) who had natural deliveries after week 38, same-day faeces of newborns when available (eighty-one from breast milk and fifty-five from infant formula fed) and six infant formulas were collected and the polyamine content was determined by HPLC. In breast milk, polyamines and isoamylamine (a primary amine), with inter-individual variations, increased over time (with a higher content of spermidine; no other amines were present). Overall, they were much higher than in infant formula. By the 2nd week after birth, polyamines, cadaverine and tyramine, but not isoamylamine, were higher in the faeces of those fed infant formula compared with those fed breast milk. Cadaverine and tyramine could be used to predict the feeding type used for newborns. The differences in the content may be related to distinct colonisation of amine-producing bacteria, which can be established by polyamines. Further studies are required to determine the clinical utility of these findings.

Differences in Vitamin E and C Profile Between Infant Formula and Human Milk and Relative Susceptibility to Lipid Oxidation

2013 ◽  
Vol 83 (5) ◽  
pp. 311-319 ◽  
Author(s):  
Ingrid Elisia ◽  
David D. Kitts
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Vitamin C ◽  
Human Milk ◽  
Lipid Oxidation ◽  
Infant Formula ◽  
Milk Formula ◽  
Infant Formulas ◽  
Vitamin E And C ◽  
Vit C

The vitamin E isoforms and vitamin (vit) C content of infant formulas were compared to human milk and related to relative susceptibilities to lipid peroxidation. We report that a highly distinct vitamin E and C profile exists between formula and human milk. Whileα-tocopherol (α-Toc) is the dominant vit E isoform in human milk, formula contains a substantial amount of α-Toc and δ-Toc that was greater than the level found in human milk (12- and 32-fold, respectively). Vitamin C was also two- fold higher in infant formula compared to human milk. Despite the higher vitamin E and C content, we also observed higher rates of lipid oxidation in the formula when compared to human milk. Storing human milk for one day at refrigeration temperatures did not produce hexanal in human milk, but this storage resulted in an increase in hexanal in formulas. We conclude that the higher concentrations of γ-Toc and δ-Toc in infant formulas did not provide similar protection from lipid oxidation as human milk. We also observed that vit C content was reduced during storage in both infant formula and human milk, which did not occur with the Toc isoforms.

Current Methods for the Analysis of Selected Novel Nutrients in Infant Formulas and Adult Nutritionals

2016 ◽  
Vol 99 (1) ◽  
pp. 30-41 ◽  
Author(s):  
Brendon D Gill ◽  
Harvey E Indyk ◽  
David C Woollard
Keyword(s):  
Sialic Acid ◽  
Breast Milk ◽  
Infant Formula ◽  
Analytical Methods ◽  
Infant Nutrition ◽  
Sole Source ◽  
Human Infant ◽  
Infant Formulas ◽  
Representative Selection

Abstract Infant formula is designed to provide the human infant with a sole source of nutrition and it is intended to imitate breast milk. In recent years, advances in the science of infant nutrition have led to an increasing number of novel ingredients that are supplemented into infant formula. As the list of these nutritionally important nutrients is lengthy, this review summarizes contemporary analytical methods that have been applied to a representative selection (lutein, carnitine, choline, nucleotides, inositol, taurine, sialic acid, gangliosides, triacylglycerides, oligosaccharides, α-lactalbumin, and lactoferrin).

scholarly journals Oligosaccharides in infant formula: more evidence to validate the role of prebiotics

2015 ◽  
Vol 113 (9) ◽  
pp. 1339-1344 ◽  
Author(s):  
Yvan Vandenplas ◽  
Irina Zakharova ◽  
Yulia Dmitrieva
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Infant Formula ◽  
Formula One ◽  
Beneficial Effects ◽  
Golden Standard ◽  
Defecation Frequency ◽  
One Step ◽  
Prebiotic Oligosaccharides ◽  
Breast Fed

The gastrointestinal (GI) microbiota differs between breast-fed and classic infant formula-fed infants. Breast milk is rich in prebiotic oligosaccharides (OS) and may also contain some probiotics, but scientific societies do not recommend the addition of prebiotic OS or probiotics to standard infant formula. Nevertheless, many infant formula companies often add one or the other or both. Different types of prebiotic OS are used in infant formula, including galacto-oligosaccharide, fructo-oligosaccharide, polydextrose and mixtures of these OS, but none adds human milk OS. There is evidence that the addition of prebiotics to infant formula brings the GI microbiota of formula-fed infants closer to that of breast-fed infants. Prebiotics change gut metabolic activity (by decreasing stool pH and increasing SCFA), have a bifidogenic effect and bring stool consistency and defecation frequency closer to those of breast-fed infants. Although there is only limited evidence that these changes in GI microbiota induce a significant clinical benefit for the immune system, interesting positive trends have been observed in some markers. Additionally, adverse effects are extremely seldom. Prebiotics are added to infant formula because breast milk contains human milk OS. Because most studies suggest a trend of beneficial effects and because these ingredients are very safe, prebiotics bring infant formula one step closer to the golden standard of breast milk.

scholarly journals A Validated Method for Detection and Quantitation of 2’Fucosyllactose in Infant Formula Matrices

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Pedro A. Prieto ◽  
Michael B. Miklus ◽  
Cynthia M. Barber ◽  
Steven M. Tennyson
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Limit Of Detection ◽  
Soluble Carbohydrates ◽  
Infant Formulas ◽  
Chromatography Method ◽  
Elution Time ◽  
Potential Health ◽  
Main Challenge ◽  
Limit Of Quantitation

Analytical methods to assess the content of free carbohydrates in solution range from simple tests of reductive power to combinations of chromatography and mass spectrometry. Soluble carbohydrates such as lactose, maltose, fructooligosaccharides, and galactooligosaccharides are commonly found in infant formulas either as sources of energy or soluble fibers. On the other hand, a rich repertoire of lactose-based carbohydrates occurs naturally in human milk.  The advent of novel biosynthesis technologies resulted in the availability of human milk oligosaccharide structures that are being used as ingredients in infant formulas.   Notably, 2’Fucosyllactose has been tested in preclinical and clinical studies to determine its safety and to explore its potential health benefits in the context of pediatric nutrition. Several chromatographic methods for the analysis of human milk oligosaccharides have been published and, the main challenge associated with 2’Fucosyllactose quantitation has been to improve its resolution from lactose, which is present at concentrations around 70 g/l in both, infant formula and human milk. We developed a high-performance anion exchange chromatography method to detect and quantify 2’ Fucosyllactose in the presence of lactose by expanding the elution time between these saccharides. We validated the analytical procedure which behaved linearly (average R=0.99951) at concentrations as low as 1.75 µg/ml (limit of quantitation) with an average limit of detection of 0.43 µg/ml.

scholarly journals Bioactive Compounds in Infant Formula and Their Effects on Infant Nutrition and Health: A Systematic Literature Review

2021 ◽  
Vol 2021 ◽  
pp. 1-31
Author(s):  
Cristine Couto Almeida ◽  
Bianca Figueiredo Mendonça Pereira ◽  
Katia Christina Leandro ◽  
Marion Pereira Costa ◽  
Bernardete Ferraz Spisso ◽  
...  
Keyword(s):  
Literature Review ◽  
Human Milk ◽  
Infant Formula ◽  
Bioactive Compounds ◽  
Systematic Literature Review ◽  
Infant Nutrition ◽  
Infant Formulas ◽  
Nutrition And Health ◽  
Bioactive Ingredients ◽  
Formula Composition

Infant formulas are an alternative to replace or supplement human milk when breastfeeding is not possible. The knowledge of human milk’s bioactive compounds and their beneficial effects has attracted the interest of researchers in the field of infant nutrition, as well as researchers of technology and food sciences that seek to improve the nutritional characteristics of infant formulas. Several scientific studies evaluate the optimization of infant formula composition. The bioactive compound inclusion has been used to upgrade the quality and nutrition of infant formulas. In this context, the purpose of this systematic literature review is to assess the scientific evidence of bioactive compounds present in infant formulas (α-lactalbumin, lactoferrin, taurine, milk fat globule membrane, folates, polyamines, long-chain polyunsaturated fatty acids, prebiotics, and probiotics) and their effects on infant nutrition and health. Through previously determined criteria, studies published in the last fifteen years from five different databases were included to identify the advances in the optimization of infant formula composition. Over the last few years, there has been optimization of the infant formula composition, not only to increase the similarities in their content of macro and micronutrients but also to include novel bioactive ingredients with potential health benefits for infants. Although the infant food industry has advanced in the last years, there is no consensus on whether novel bioactive ingredients added to infant formulas have the same functional effects as the compounds found in human milk. Thus, further studies about the impact of bioactive compounds in infant nutrition are fundamental to infant health.

Characteristics of Human Breast Milk Based on Infant’s Gender

2019 ◽  
Vol 5 (1) ◽  
pp. 8-10
Author(s):  
Moudah Alhindi ◽  
Hadohum Musallam ◽  
Esam Elhefian
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Physicochemical Properties ◽  
Infant Formula ◽  
Human Breast Milk ◽  
Human Breast ◽  
Milk Samples ◽  
Complex Fluid ◽  
Infant Sex ◽  
Calcium And Magnesium

Human milk is a complex fluid, which contains a number of constituents such as fats, proteins and vitamins, in addition to other compounds. These nutrients are needed for infant protection against infections and diseases. This study was undertaken to evaluate some physicochemical properties and biochemical constituents content of human milk samples (based on the gender of the breast feeding infant). This includes acidity, density and viscosity, as well as lactose, protein, calcium and magnesium contents. Results showed that the highest value of viscosity as well as the highest percentages of protein and acidity were recorded for human breast milk for a boy (2.212 cP, 1.237% and 0.02% respectively) while close values for density and other biochemical contents were recorded for both types of samples. However, only the change in viscosity was found to be significant (p?0.05). Variations in some properties of human milk depending on the infant' sex could be of benefit for developing infant formula taking infant’s gender into consideration.

scholarly journals Comparison of the Bifidogenic Effects of Goat and Cow Milk-Based Infant Formulas to Human Breast Milk in an in vitro Gut Model for 3-Month-Old Infants

2020 ◽  
Vol 7 ◽  
Author(s):  
Sophie Gallier ◽  
Pieter Van den Abbeele ◽  
Colin Prosser
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Goat Milk ◽  
Cow Milk ◽  
Common Source ◽  
Human Breast Milk ◽  
Infant Formulas ◽  
Infant Gut Microbiome

Human milk contains prebiotic components, such as human milk oligosaccharides (HMOs), which stimulate the growth of specific members of the infant gut microbiota (e.g., Bifidobacteria). Plant-based or synthetic oligosaccharides are often added to infant formulas to simulate the bifidogenic effect of HMOs. Cow milk, the most common source of protein in infant formula, and goat milk, used increasingly in the manufacture of infant formula, contain naturally-occurring prebiotics. This study compared the upper gastrointestinal digestion and subsequent colonic fermentation of human milk vs. goat and cow milk-based infant formulas (goat IF and cow IF, respectively), without additional oligosaccharides using an in vitro model for 3-month-old infants based on the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®). First, a dialysis approach using 3.5 kDa membranes was demonstrated to simulate small intestinal absorption of carbohydrates in conditions similar to those in vivo. During the in vitro digestion experiment, oligosaccharides were detected in human milk and goat IF but barely detected in the cow IF. Further, all three milk matrices decreased colonic pH by boosting acetate, lactate, and propionate production, which related to increased abundances of acetate/lactate-producing Bifidobacteriaceae for human milk (+25.7%) and especially goat IF (33.8%) and cow IF (37.7%). Only cow IF stimulated butyrate production which correlated with an increase in Lachnospiraceae and Clostridiaceae. Finally, Enterobacteriaceae and Acidaminococcaceae also increased with all three milk matrices, while production of proteolytic metabolites (branched-chain fatty acids) was only detected for the cow IF. Overall, goat and cow milk-based formulas without added oligosaccharides impacted gut microbial activity and composition similarly to human milk. This suggests that even without supplementation of formula with oligosaccharides, whole goat milk, whole cow milk and cow milk ingredients already supply compounds in formulas that exert beneficial bifidogenic effects. Further clinical research is warranted to elucidate the effect of whole goat milk-based formulas on the infant gut microbiome.

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