scholarly journals Cognitive Improvement and Safety Assessment of a Dietary Supplement Containing Propolis Extract in Elderly Japanese: A Placebo-Controlled, Randomized, Parallel-Group, Double-Blind Human Clinical Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Takashi Asama ◽  
Toshihito Hiraoka ◽  
Akio Ohkuma ◽  
Nobuaki Okumura ◽  
Ayanori Yamaki ◽  
...  
Keyword(s):  
Uric Acid ◽  
Information Processing ◽  
Placebo Group ◽  
Cognitive Function ◽  
Dietary Supplement ◽  
Verbal Memory ◽  
Urea Nitrogen ◽  
Propolis Extract ◽  
Elderly Japanese ◽  
Complex Attention

Objectives. This study aimed to evaluate the effect of propolis on cognitive function in elderly Japanese with a placebo-controlled design. Material and Methods. This study was performed on 79 elderly Japanese. Participants orally received either a placebo or dietary supplement containing propolis extract for 24 weeks. Cognitive function assessed by Cognitrax and various blood or urine markers were measured at pre- and postadministration. Results and Conclusion. Eligible data from 68 subjects (placebo: 33, propolis: 35) who completed the study were analyzed. Compared to the placebo group, the propolis group showed significant improvement in verbal memory in Cognitrax ( P = 0.028 ). Total cholesterol, LDL cholesterol, urea nitrogen, creatinine, and uric acid were significantly improved in the propolis group compared to the placebo group ( P = 0.011 , P = 0.004 , P = 0.048 , P = 0.045 , and P = 0.005 , respectively). However, urea nitrogen, creatinine, and uric acid fluctuated within the normal level. Furthermore, a subgroup analysis was performed on those with higher than 100 of the standardized score of the neurocognitive index indicated by the overall Cognitrax score. Significant improvements in the propolis group compared to placebo were confirmed in verbal memory ( P = 0.007 ) and processing speed as indications for information processing ability, complex attention, and concentration ( P = 0.029 ). No side effects were observed in any of the groups. This study demonstrates that propolis is effective in improving cognitive functions such as memory, information processing, complex attention, and concentration in elderly Japanese.

Lack of a chemobrain effect for adjuvant FOLFOX chemotherapy in colon cancer patients: A pilot study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14018-e14018
Author(s):  
Alberto Zaniboni ◽  
Federica Andreis ◽  
Marco Ferri ◽  
Maria Mazzocchi ◽  
Fausto Meriggi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Cognitive Function ◽  
Cancer Patients ◽  
Processing Speed ◽  
Verbal Memory ◽  
Verbal Learning ◽  
Information Processing Speed ◽  
Trial Making Test

e14018 Background: Chemotherapy improves the survival rate of stage III colon cancer patients. The combination of oxaliplatin, 5-fluorouracil and leucovorin (the FOLFOX4 regimen) has emerged as the standard of care. Cognitive changes and disfunction after cancer chemotherapy are increasingly reported as a disturbing side-effect in cancer survivors. This prospective study evaluates potential alterations in cognitive function in Folfox4-treated patients. Methods: We evaluated 57 consecutive colorectal cancer patients who received adjuvant chemotherapy with FOLFOX4. Patients underwent a complete battery of neuropsychological tests at three different times: before (T0), at the end (T1) and six months after treatment (T2). Changes in neuropsychological test scores at T0, T1 and T2 were compared with a two tail t-test (T1-T0, T2-T1, T2-T0), using the repeated measure ANOVA model. Results: We have analyzed cognitive impairment (Mini Mental State Examination, MMSE), visuo-spatial memory, information processing speed (Trial Making Test-A and Trial Making Test-B), verbal memory (Rey Auditory Verbal Learning Test), emotional distress (Psychological Distress Inventory), anxiety (State and Trait Anxiety Inventory) and depression (Beck Depression Inventory). We found no cognitive impairment in time considered, as we found a median MMSE score of 27,51 ± 1,21 at T0, 27,63 ± 0,65 at T1 and 27,26 ± 1,17 at T2. We noticed some transient variations in tests evaluating verbal memory and in information processing speed performances. The only significative scores modifications were those related to anxiety and depression. Conclusions: We found no significant effect on cognitive function related to chemotherapy, the only little modification is about some emotional performance during chemotherapy. These findings may be explained by the central role of the psychological adaptation process, which occurs during the period from diagnosis to completion of treatment and is characterized by anxiety and adjustment depression. Our results seem to rule out any significant cognitive impairment due to adjuvant Folfox4 chemotherapy in colon cancer patients.

scholarly journals The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 14 (12) ◽  
pp. 1235
Author(s):  
I-Chen Tsai ◽  
Chih-Wei Hsu ◽  
Chun-Hung Chang ◽  
Ping-Tao Tseng ◽  
Ke-Vin Chang
Keyword(s):  
Working Memory ◽  
Placebo Group ◽  
Cognitive Function ◽  
Processing Speed ◽  
Verbal Memory ◽  
Meta Analysis ◽  
Visual Learning ◽  
Clinical Effectiveness ◽  
Cognitive Domains ◽  
Significant Difference

Curcumin is a polyphenol with strong antioxidant and anti-inflammatory effects that has been shown to be effective in ameliorating cognitive decline in animal studies. However, its clinical effectiveness is inconclusive, and relevant gastrointestinal adverse events (AEs) have been reported. The aim of this meta-analysis was to summarize the existing evidence from randomized controlled trials (RCTs) of effects of curcumin on overall cognitive function, individual cognitive domains, and gastrointestinal AE. The study includes 8 RCTs and 389 participants. A random-effects model was used for the meta-analysis. Compared with the placebo group, the curcumin group was associated with an improvement in working memory (Hedges’ g = 0.396, 95% confidence interval (CI) = 0.078 to 0.714, p = 0.015) and a borderline benefit in processing speed (Hedges’ g = 0.303, 95% CI = ‒0.013 to 0.619, p = 0.06). In the domains of language, episodic memory/visual learning, verbal memory, cognitive flexibility/problem solving, and overall cognitive function, no significant difference existed for the comparison between the curcumin and placebo groups. The curcumin group had a significantly higher risk of gastrointestinal AEs than the placebo group (odds ratio = 3.019, 95% CI = 1.118 to 8.150, p = 0.029). In the future, the effects of curcumin on working memory, processing speed, and gastrointestinal AE should be further investigated.

scholarly journals Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential

Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1130
Author(s):  
Michio Hashimoto ◽  
Kentaro Matsuzaki ◽  
Shahdat Hossain ◽  
Tomoko Ito ◽  
Harumi Wakatsuki ◽  
...  
Keyword(s):  
Mental Health ◽  
Cognitive Function ◽  
Plasma Membranes ◽  
Seed Oil ◽  
Antioxidant Potential ◽  
Control Group ◽  
Healthy Elderly ◽  
Age Related ◽  
Elderly Japanese ◽  
Perilla Seed

Oxidative stress plays an important role in age-associated cognitive decline. We recently reported that dietary intake of perilla seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of dietary PO intake on cognitive functions and mental health in healthy, elderly Japanese individuals. Seventy-five healthy volunteers aged 64–84 years were randomly divided into two groups: a control group and a PO-administered group. At baseline and at 12 months of intervention, cognitive function, mental health condition, fatty acid profile of the red blood cell plasma membranes (RBC-PM), and serum biochemical parameters were evaluated. Results showed that serum biological antioxidant potential and LNA levels in the RBC-PM at 12 months after the trial were significantly higher in the PO group compared to the control group. Further, both the cognitive function measures, as evaluated by the Frontal Assessment Battery test and the apathy scores, tended to be improved after 12 months in the PO group. Our results demonstrate that dietary PO intake enhances the antioxidant potential and prevents the age-related cognitive and mental decline in healthy elderly individuals by enhancing the blood LNA levels.

scholarly journals Serum sodium in relation to various domains of cognitive function in the elderly US population

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sohyae Lee ◽  
Jin-young Min ◽  
Beom Kim ◽  
Sang-Won Ha ◽  
Jeohng Ho Han ◽  
...  
Keyword(s):  
Executive Function ◽  
Cognitive Function ◽  
Serum Sodium ◽  
Verbal Memory ◽  
The Elderly ◽  
Cognitive Change ◽  
Cognitive Test ◽  
P Value ◽  
Digit Symbol Substitution Test ◽  
Cross Sectional

Abstract Background Recent evidence suggests that sodium imbalances may be associated with cognitive impairment; however, the association between specific domains of cognition remains unclear. This study examines the association between serum sodium levels and immediate and delayed verbal memory as measured by the CERAD Word Learning Test (CERAD WLT), executive function as measured by the Animal Fluency test (AFT), and sustained attention, working memory, and processing speed as measured by the Digit Symbol Substitution test (DSST) in the elderly population of the US aged 60 and older who participated in the 2011–2014 National Health and Nutrition Examination Surveys (n = 2,541). Methods Cognitive function tests were performed by trained interviewers and sodium levels were measured using indirect ion selective electrode methodology. Results After adjusting for all covariates, quintiles of CERAD WLT scores showed significant positive associations with log-transformed sodium levels (Immediate recall (IR) β = 4.25 (SE = 1.83, p-value 0.027); Delayed recall (DR) β = 6.54 (SE = 1.82, p-value 0.001)). Compared to normal sodium levels, hyponatremia was significantly associated with lower CERAD WLT-IR (β = -0.34, SE = 0.15, p-value 0.035) and CERAD WLT-DR scores (β -0.48, SE = 0.10, p-value < 0.001) and showed borderline significance with AFT scores (β = = -0.38, SE = 0.19, p-value 0.052). Hypernatremia did not show any significant relationships with cognitive test scores, compared to normal sodium levels. Conclusions Our cross-sectional study showed that lower sodium levels were associated with cognitive change, especially regarding memory and executive function.

Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing

2017 ◽  
Vol 637 ◽  
pp. 182-187 ◽  
Author(s):  
Shuangling Xiu ◽  
Zheng Zheng ◽  
Shaochen Guan ◽  
Jin Zhang ◽  
Jinghong Ma ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cognitive Function ◽  
Serum Uric Acid ◽  
Community Dwelling ◽  
Impaired Cognitive Function

The Relationship Between Habitual Physical Activity, Sitting Time, and Cognitive Function in Young Adult Women

2021 ◽  
pp. 1-6
Author(s):  
Eka Peng Cox ◽  
Rebecca Cook ◽  
Nicholas O’Dwyer ◽  
Cheyne Donges ◽  
Helen Parker ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Information Processing ◽  
Cognitive Function ◽  
Body Mass ◽  
High Intensity ◽  
Analysis Of Covariance ◽  
Sitting Time ◽  
Adult Women ◽  
Normal Ranges

Background: There is evidence that physical activity (PA), sitting time, and obesity may impact cognition, but few studies have examined this in young women. Methods: Healthy women (18–35 y), without conditions that impair cognition, were recruited for this cross-sectional study. Participants completed anthropometric and validated computerized cognitive assessments (IntegNeuro™). Performance on 5 cognitive domains (impulsivity, attention, information processing, memory, and executive function) was reported as z scores. Sitting hours and weekly PA calculated from time in low-, moderate-, and high-intensity activity were obtained via the International Physical Activity Questionnaire. Analysis of variance/analysis of covariance, chi-square, and linear regression were used. Results: 299 (25.9 [5.1] y) women (low PA = 19%; moderate PA = 40%; high PA = 41%) participated. High PA women had lower body mass index (high PA = 26.1 [6.5]; moderate PA = 30.0 [8.7]; low PA = 31.0 [11.1] kg/m2; P < .001) and less sitting time (high PA = 6.6 [3.1]; moderate PA = 7.7 [2.8]; low PA = 9.3 [3.6] hr/weekday; P < .0001). Cognitive function was within normal ranges and did not differ between any PA groups (P = .42). Adjusting for body mass index, C-reactive protein, or sitting hours did not alter results. Weak correlations were found between time in high-intensity activity and impulsivity (b = 0.12, r2 = .015; P = .04), and between sitting hours and information processing efficiency (b = −0.18, r2 = .03; P = .002). Valuesare presented as mean (SD). Conclusions: Cognitive function was within the normal range, regardless of PA or sitting time.

scholarly journals Effects of luteolin-rich chrysanthemum flower extract on purine base absorption and blood uric acid in Japanese subjects

2022 ◽  
Vol 12 (1) ◽  
pp. 12
Author(s):  
Tsuyoshi Takara ◽  
Kazuo Yamamoto ◽  
Naoko Suzuki ◽  
Shin-ichiro Yamashita ◽  
Shin-ichiro Iio ◽  
...  
Keyword(s):  
Uric Acid ◽  
Placebo Group ◽  
Serum Uric Acid ◽  
Random Number Generator ◽  
Double Blind ◽  
Japanese Men ◽  
Purine Base ◽  
Flower Extract ◽  
Before And After ◽  
Body Parameters

Background and objective: Chrysanthemum flowers are consumed as fresh condiments, herbal teas, and processed foods in Japan and Taiwan. They contain luteolin as a major polyphenol and are traditionally used for eye care. We previously demonstrated that the ingestion of Chrysanthemum flower extract (CFE) for 1 month reduced serum uric acid levels. However, the findings obtained were considered to be biased because the study was performed by a CFE manufacturer. Therefore, we herein conducted a clinical trial on CFE on a larger scale and examined its effects on purine base absorption from the intestines, which represents an effective approach for reducing serum uric acid levels. Methods: Both studies were performed as randomized, double-blind, placebo-controlled trials and CFE (100 mg) containing 1 mg of luteolin was used as the active sample. We enrolled 44 healthy Japanese men and women with 6.0 to 7.9 mg/dL serum uric acid. All subjects were randomly allocated to an active group (n=22) or placebo group (n=22) using a computerized random number generator. In the purine base absorption study, CFE was ingested with a purine base-rich diet and serum uric acid levels were measured chronologically. In the 12-week consecutive ingestion study, CFE or placebo was administered between January and April 2021. Serum uric acid levels after 12 weeks were assessed as the primary outcome, and uric acid were measured before and after 4 weeks of the intervention as secondary outcomes. Blood, urine and body parameters were examined to evaluate the safety of CFE. Results: Thirty-nine subjects completed the trial, and the per protocol set comprised 18 and 21 subjects in the active and placebo groups, respectively. In the single dosing study of CFE on subjects loaded by the purine base-rich diet, no significant changes were observed between the CFE and placebo groups. On the other hand, in the 12-week ingestion study, serum uric acid levels were significantly lower in the CFE group than in the placebo group. Laboratory tests revealed no abnormalities to suggest any side effects of CFE.Conclusions: CFE (100 mg/day) containing 1 mg of luteolin reduced serum uric acid levels. CFE may be beneficial for improving hyperurichemia. Trial Registration: UMIN-CTR: UMIN000042327Foundation: The present study was funded by Oryza Oil & Fat Chemical Co., Ltd. Keywords: Chrysanthemum, luteolin, uric acid, purine base

scholarly journals Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes

2021 ◽  
Vol 10 (22) ◽  
pp. 5307
Author(s):  
Alicja Popiołek ◽  
Bartosz Brzoszczyk ◽  
Piotr Jarzemski ◽  
Aleksandra Chyrek-Tomaszewska ◽  
Radosław Wieczór ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Prostate Specific Antigen ◽  
Verbal Memory ◽  
Demographic Data ◽  
Specific Antigen ◽  
Hormonal Treatment ◽  
Cognitive Test ◽  
Prostate Cancer Survivors

Prostate cancer (PC) is one of the most common malignancies in men. The increase in the number of PC survivors is associated with many problems including cognitive impairment. Early detection of such problems facilitates timely protective intervention. This study examined the association between prostate-specific antigen (PSA) or testosterone (T) levels and cognitive function in patients undergoing radical prostatectomy. Such a correlation could help identify patient groups at risk of cognitive impairment. Participants underwent clinical (demographic data, medical history, physical examination, and blood analyses) and neuropsychological assessment (cognitive test battery). Preoperative PSA or T levels were not associated with cognitive function. However, long-term follow-up after prostatectomy showed a strong correlation between PSA levels and the results of verbal memory and executive function tests. A trend toward significance was also observed for visuospatial memory. The levels of free T and total T were not correlated with cognitive function. Only the levels of free T after hormonal treatment were significantly correlated with executive functions. Comorbid diabetes affected these correlations. In conclusion, PSA levels at a distant postoperative time and free T level after hormonal treatment may be biomarkers of cognitive function.

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