scholarly journals The Role of CARD9 Deficiency in Neutrophils

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Ruanmei Sheng ◽  
Xiaoming Zhong ◽  
Zhiwen Yang ◽  
Xuemin Wang
Keyword(s):  
Critical Role ◽  
Myeloid Cell ◽  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense ◽  
The Central Nervous System ◽  
Clinical Advances ◽  
Insight Into ◽  
Increased Susceptibility

Neutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. Great efforts are underway to better understand the nature of neutrophilic inflammation. Of note, CARD9, a myeloid cell-specific signaling protein that mainly expresses in macrophages and dendritic cells, is also present in neutrophils, emerging as a critical mediator for intercellular communication. CARD9–deficiency neutrophils display an increased susceptibility to fungal infection that primarily localize to the central nervous system, subcutaneous, and skin tissue. Additionally, CARD9–deficiency neutrophils are associated with some autoimmune diseases and even provide protection against a few bacteria. Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils.

Critical Role For Muc5b In Innate Immune Defense In Vivo

2012 ◽  
Author(s):  
Christopher M. Evans ◽  
Michelle Roy ◽  
Melissa L. McElwee ◽  
Ryan Boerner ◽  
Victoria N. Mdoe ◽  
...  
Keyword(s):  
Critical Role ◽  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense

scholarly journals The Role of Collectins and Galectins in Lung Innate Immune Defense

2018 ◽  
Vol 9 ◽  
Author(s):  
Cristina Casals ◽  
María A. Campanero-Rhodes ◽  
Belén García-Fojeda ◽  
Dolores Solís
Keyword(s):  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense

scholarly journals The Role of Taste Receptors in Airway Innate Immune Defense

Sinusitis ◽  
2018 ◽  
Vol 3 (2) ◽  
pp. 6
Author(s):  
Alan Workman ◽  
Neil Patel ◽  
Ryan Carey ◽  
Edward Kuan ◽  
Noam Cohen
Keyword(s):  
Immune Defense ◽  
Innate Immune ◽  
Taste Receptors ◽  
Innate Immune Defense

scholarly journals The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

2015 ◽  
Vol 290 (31) ◽  
pp. 18954-18961 ◽  
Author(s):  
Karrera Y. Djoko ◽  
Cheryl-lynn Y. Ong ◽  
Mark J. Walker ◽  
Alastair G. McEwan
Keyword(s):  
Bacterial Pathogens ◽  
Immune Defense ◽  
Innate Immune ◽  
Zinc Toxicity ◽  
Innate Immune Defense ◽  
Copper And Zinc

scholarly journals Microglia: An Active Player in the Regulation of Synaptic Activity

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Kyungmin Ji ◽  
Jeremy Miyauchi ◽  
Stella E. Tsirka
Keyword(s):  
Central Nervous System ◽  
Critical Role ◽  
Innate Immune ◽  
Synaptic Activity ◽  
Cell Type ◽  
Synaptic Development ◽  
Active Player ◽  
The Central Nervous System ◽  
Shed Light

Synaptic plasticity is critical for elaboration and adaptation in the developing and developed brain. It is well established that astrocytes play an important role in the maintenance of what has been dubbed “the tripartite synapse”. Increasing evidence shows that a fourth cell type, microglia, is critical to this maintenance as well. Microglia are the resident macrophages of the central nervous system (CNS). Because of their well-characterized inflammatory functions, research has primarily focused on their innate immune properties. The role of microglia in the maintenance of synapses in development and in homeostasis is not as well defined. A number of significant findings have shed light on the critical role of microglia at the synapse. It is becoming increasingly clear that microglia play a seminal role in proper synaptic development and elimination.

scholarly journals Illuminating the Role of Vitamin A in Skin Innate Immunity and the Skin Microbiome: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 302
Author(s):  
Fritzlaine C. Roche ◽  
Tamia A. Harris-Tryon
Keyword(s):  
Vitamin A ◽  
Innate Immune ◽  
Narrative Review ◽  
Skin Microbiome ◽  
Skin Infections ◽  
Inflammatory Skin Disease ◽  
Skin Immunity ◽  
Impaired Immune Response ◽  
Increased Susceptibility

Vitamin A is a fat-soluble vitamin that plays an important role in skin immunity. Deficiencies in Vitamin A have been linked to impaired immune response and increased susceptibility to skin infections and inflammatory skin disease. This narrative review summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that promote skin immunity and sustain the skin microbiome.

The roles of grouper TANK in innate immune defense against iridovirus and nodavirus infections

2020 ◽  
Vol 104 ◽  
pp. 506-516
Author(s):  
Jingguang Wei ◽  
Chen Li ◽  
Jisheng Ou ◽  
Xin Zhang ◽  
Zetian Liu ◽  
...  
Keyword(s):  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense

Science and Theology for Everyone: How Climate Science is Shaping Christianity in the UK

2021 ◽  
Vol 62 (2) ◽  
pp. 147-157
Author(s):  
Caleb Gordon ◽  
Hannah Malcolm
Keyword(s):  
Critical Role ◽  
Climate Science ◽  
Significant Shift ◽  
Christian Life ◽  
Ethical Problems ◽  
Technical Leadership ◽  
Science And Theology ◽  
The Uk ◽  
Insight Into

This article analyses the growing participation of UK Christians in climate initiatives over the last five years. In many cases, climate science is cited as a necessary consideration for the fulfilment of already-existing Christian commitments. This represents a significant shift in the ways UK Christians understand the role of dialogue between theology and the sciences; previous science and theology dialogue has usually been treated as an area of expert concern, primarily offering insight into apologetics or specific ethical problems. By contrast, the dialogue between climate science and theology has seen the emergence of non-technical leadership amid the expectation that climate science plays a critical role in re-examining the meaning of Christian life, both for individuals and as communities.

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