scholarly journals The Role of Taste Receptors in Airway Innate Immune Defense

Sinusitis ◽  
2018 ◽  
Vol 3 (2) ◽  
pp. 6
Author(s):  
Alan Workman ◽  
Neil Patel ◽  
Ryan Carey ◽  
Edward Kuan ◽  
Noam Cohen
Keyword(s):  
Immune Defense ◽  
Innate Immune ◽  
Taste Receptors ◽  
Innate Immune Defense

scholarly journals The Role of CARD9 Deficiency in Neutrophils

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Ruanmei Sheng ◽  
Xiaoming Zhong ◽  
Zhiwen Yang ◽  
Xuemin Wang
Keyword(s):  
Critical Role ◽  
Myeloid Cell ◽  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense ◽  
The Central Nervous System ◽  
Clinical Advances ◽  
Insight Into ◽  
Increased Susceptibility

Neutrophils play a critical role in innate immune defense and directly contribute to infectious and autoimmune ailments. Great efforts are underway to better understand the nature of neutrophilic inflammation. Of note, CARD9, a myeloid cell-specific signaling protein that mainly expresses in macrophages and dendritic cells, is also present in neutrophils, emerging as a critical mediator for intercellular communication. CARD9–deficiency neutrophils display an increased susceptibility to fungal infection that primarily localize to the central nervous system, subcutaneous, and skin tissue. Additionally, CARD9–deficiency neutrophils are associated with some autoimmune diseases and even provide protection against a few bacteria. Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils.

scholarly journals The Role of Collectins and Galectins in Lung Innate Immune Defense

2018 ◽  
Vol 9 ◽  
Author(s):  
Cristina Casals ◽  
María A. Campanero-Rhodes ◽  
Belén García-Fojeda ◽  
Dolores Solís
Keyword(s):  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense

scholarly journals The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

2015 ◽  
Vol 290 (31) ◽  
pp. 18954-18961 ◽  
Author(s):  
Karrera Y. Djoko ◽  
Cheryl-lynn Y. Ong ◽  
Mark J. Walker ◽  
Alastair G. McEwan
Keyword(s):  
Bacterial Pathogens ◽  
Immune Defense ◽  
Innate Immune ◽  
Zinc Toxicity ◽  
Innate Immune Defense ◽  
Copper And Zinc

The roles of grouper TANK in innate immune defense against iridovirus and nodavirus infections

2020 ◽  
Vol 104 ◽  
pp. 506-516
Author(s):  
Jingguang Wei ◽  
Chen Li ◽  
Jisheng Ou ◽  
Xin Zhang ◽  
Zetian Liu ◽  
...  
Keyword(s):  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense

scholarly journals Role of Taste Receptors as Sentinels of Innate Immunity in the Upper Airway

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Neil N. Patel ◽  
Alan D. Workman ◽  
Noam A. Cohen
Keyword(s):  
Airway Epithelium ◽  
Taste Receptor ◽  
Upper Airway ◽  
Airway Disease ◽  
G Protein Coupled Receptors ◽  
Innate Immune ◽  
Taste Receptors ◽  
Taste Sensation ◽  
G Protein Coupled

Evidence is emerging that shows taste receptors serve functions outside of taste sensation of the tongue. Taste receptors have been found in tissue across the human body, including the gastrointestinal tract, bladder, brain, and airway. These extraoral taste receptors appear to be important in modulating the innate immune response through detection of pathogens. This review discusses taste receptor signaling, focusing on the G-protein–coupled receptors that detect bitter and sweet compounds in the upper airway epithelium. Emphasis is given to recent studies which link the physiology of sinonasal taste receptors to clinical manifestation of upper airway disease.

Black carp STING functions importantly in innate immune defense against RNA virus

2017 ◽  
Vol 70 ◽  
pp. 13-24 ◽  
Author(s):  
Liang Lu ◽  
Xu Wang ◽  
Sizhong Wu ◽  
Xuejiao Song ◽  
Ziqi Zou ◽  
...  
Keyword(s):  
Rna Virus ◽  
Immune Defense ◽  
Innate Immune ◽  
Black Carp ◽  
Innate Immune Defense

scholarly journals Innate immune defense in the inner ear - mucines are expressed by the human endolymphatic sac

2016 ◽  
Vol 230 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Martin N. Møller ◽  
Svend Kirkeby ◽  
Per Cayé-Thomasen
Keyword(s):  
Inner Ear ◽  
Immune Defense ◽  
Innate Immune ◽  
Endolymphatic Sac ◽  
Innate Immune Defense
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