scholarly journals Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Zahra Hadian ◽  
Ali Akbar Moghadamnia ◽  
Sohrab Kazemi ◽  
Atena Shirzad
Keyword(s):  
Quality Of Life ◽  
Inflammatory Diseases ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Omega 3 ◽  
Mucosal Disease ◽  
Related Quality ◽  
Health Related ◽  
Disease Questionnaire

Objective. Recurrent aphthous stomatitis is one of the most common chronic inflammatory diseases in oral mucosa. Beneficial effects of omega-3 supplements on some inflammatory diseases have been proved. The aim of present study was to evaluate the effect of omega-3 supplements in recurrent aphthous stomatitis management and improve oral health-related quality of life. Methods. In this double-blind clinical trial, 40 patients with minor recurrent aphthous stomatitis were randomly divided into case and control groups. The case group received 1000 mg capsules of omega-3, while the control group received placebo capsules for 6 months. The questionnaires of the ulcer severity score and the chronic oral mucosal disease questionnaire were filled by the patients in three steps, at the baseline session, after 3 months, and after 6 months. The data were analyzed by SPSS 22 software through ANOVA, Mann–Whitney, and chi-square tests. P < 0.05 was considered as significant. Results. In the omega-3 group, the ulcer severity score showed significant reduction by three-month and six-month follow-ups ( P < 0.0001 , P < 0.0001 , respectively). The mean score of the chronic oral mucosal disease questionnaire significantly improved by three-month and six-month follow-ups in the omega-3-receiving group. Conclusion. Use of omega-3 oral supplements decreased the severity of aphthous ulcer and improved oral health-related quality of life.

scholarly journals Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Nini Callan ◽  
Doug Hanes ◽  
Ryan Bradley
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Pain Intensity ◽  
Omega 3 ◽  
Oral Supplementation ◽  
Marine Lipid ◽  
Related Quality ◽  
Health Related ◽  
Hs Crp

Abstract Background Marine lipids contain omega-3 fatty acids that can be metabolized into anti-inflammatory and pro-resolving mediators—namely 17-HDHA and 18-HEPE—which can serve as modulators of the pain experience. The purpose of this study was to determine the impact of 4 weeks of oral supplementation with a fractionated marine lipid concentration, standardized to 17-HDHA and 18-HEPE, on health-related quality of life and inflammation in adults with chronic pain. Methods This study was a prospective, non-randomized, open-label clinical trial. Forty-four adults with ≥ moderate pain intensity for at least 3 months were recruited. The primary outcome was change in health-related quality of life (QOL) using the Patient Reported Outcomes Measurement Information System-43 Profile (PROMIS-43) and the American Chronic Pain Association (ACPA) QOL scale. Exploratory outcomes assessed safety and tolerability, changes in anxiety and depression, levels of pain intensity and interference, patient satisfaction, and impression of change. Changes in blood biomarkers of inflammation (hs-CRP and ESR) were also explored. Results Outcome measures were collected at Baseline, Week 2, and Week 4 (primary endpoint). At Week 4, PROMIS-43 QOL subdomains changed with significance from baseline (p < 0.05), with borderline changes in the ACPA Quality of Life scale (p < 0.052). Exploratory analyses revealed significant changes (p < 0.05) in all measures of pain intensity, pain interference, depression, and anxiety. There were no statistically significant changes in either hs-CRP or ESR, which stayed within normal limits. Conclusion We conclude that oral supplementation with a fractionated marine lipid concentration standardized to 17-HDHA and 18-HEPE may improve quality of life, reduce pain intensity and interference, and improve mood within 4 weeks in adults with chronic pain. The consistency and magnitude of these results support the need for placebo-controlled clinical trials of marine lipid concentrations standardized to 17-HDHA and 18-HEPE. Trial registration ClinicalTrials.gov: Influence of an Omega-3 SPM Supplement on Quality of Life, NCT02683850. Registered 17 February 2016—retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02683850.

Effect of personality traits on the oral health-related quality of life in patients with oral mucosal disease

2014 ◽  
Vol 19 (6) ◽  
pp. 1245-1250 ◽  
Author(s):  
Andrea Fädler ◽  
Thomas Hartmann ◽  
Thomas Bernhart ◽  
Babak Monshi ◽  
Klemens Rappersberger ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Personality Traits ◽  
Health Related Quality ◽  
Mucosal Disease ◽  
Related Quality ◽  
Health Related
Sign in / Sign up

Export Citation Format

Share Document