Information and Husband’s Support on Implementation Postpartum Gymnastics during COVID 19 Pandemic in Indonesia

Background : The practice of postnatal gymnastics in Indonesia is still little done by postpartum mothers both before and during the covid pandemic 19. Some of the contributing factors include lack of knowledge about postnatal gymnastics, fatigue, and the mother's mindset about the importance of postnatal gymnastics for health which is still lacking. Post-delivery exercise can help mothers to get back to their normal health as they were before pregnancy. Objective : This study aims to analyze the effect of information and husband's support on the implementation postnatal gymnastics during the covid 19 pandemic. Methods : Non-experimental research design: cross sectional analytic, the independent variable is husband's information and support and the dependent variable is postpartum exercise. This research was conducted in April – August 2021. The population of postpartum mothers was 102, the sampling technique was incidental sampling in Wonokromo Village, Surabaya, East Java, Indonesia. Research instrument with a questionnaire. The data were analyzed using the Multiple Logistics Regression test. Results : The results showed that partially there was a significant effect of husband's support (p = 0.013) on postnatal exercise, but for information during the pandemic there was no effect (p = 0.998) on postpartum exercise. The results of the analysis showed that the OR value of the information was 1.615E9 (95%CI: 0.000 – 0.000) and the OR of husband's support was 3.385 (95%CI: 1.289 – 8.886). Conclusion : Husband's support during the covid 19 pandemic affects mothers in doing postnatal exercise. Obtaining information about postnatal exercise during the COVID-19 pandemic does not affect the mother in its implementation.

Glycocalyx Curving the Membrane: Forces Emerging from the Cell Exterior

Morphological transitions are typically attributed to the actions of proteins and lipids. Largely overlooked in membrane shape regulation is the glycocalyx, a pericellular membrane coat that resides on all cells in the human body. Comprised of complex sugar polymers known as glycans as well as glycosylated lipids and proteins, the glycocalyx is ideally positioned to impart forces on the plasma membrane. Large, unstructured polysaccharides and glycoproteins in the glycocalyx can generate crowding pressures strong enough to induce membrane curvature. Stress may also originate from glycan chains that convey curvature preference on asymmetrically distributed lipids, which are exploited by binding factors and infectious agents to induce morphological changes. Through such forces, the glycocalyx can have profound effects on the biogenesis of functional cell surface structures as well as the secretion of extracellular vesicles. In this review, we discuss recent evidence and examples of these mechanisms in normal health and disease.

Pharmaceutical Study of Kasisa Bhasma

Ayurveda is the science of life and longevity. Its main objective is to maintain the normal health of individuals and secondary is the cure of diseases. For maintaining health it advocates the wholesome diet and proper daily routine. If any disturbance occurs in health condition of individual it then advocates the medicines for cure. The medicines are of herbal, mineral and herbo-mineral in origin. Bhasmas are unique Ayurvedic preparations of metals/minerals formulated with herbal extracts or juices and used for the treatment of a variety of ailments. Bhasma is prepared by incinerating the metals and minerals. For incineration classical and modern methods are used. The Classical Method of Bhasma preparation is Puta and modern method is Electric Muffle Furnace. The herbal juices are used for levigation of powders of metals and minerals. Owing to their micro/ nano fineness, ease of administration and comparatively small dose, they have been known for their wide area of application and therapeutic value. Kasisa is mineral of Iron. It is placed under Uprasa in Rasashastra. Its Bhasma is widely used in different ailments. It is used in the treatment of Agnimandya, Arsha, Kashtartava, Gudabhramsha, Pandu, Shotha, Rajorodha, Yonivyapada. In the present study Kasisa bhasma was prepared as per the reference of Rasamruta and analysed using classical parameters.

God's Consistency Which Is Promised Through a New-Normal-Era Health Protocol in Order to Preserve The Essence Of Humanity

Health anthropology has experienced a tremendous new revolution, started from last year, 2020. A New-normal Health Protocol formulation was put in place to deal with the Covid-19 pandemic outbreak. Natural and social media communities complained about humanity and human rights degradation, raising calls for resistance due to imposed global restrictive regulations. God in Christian theology is a God who promises to His human creation that He will be with and help humans to have a happy and prosperous life. By doing literature research, this paper tries to explore whether the Covid-19 management guidelines are by the consistency of covenant God in restoring the essence of humanity. How is the relation between two paradigms of society, from God’s side and human’s side, through the Health Protocol intervention? The finding is that God, who created perfect human beings, keeps all the processes of his life to become the people of His eternal kingdom. Society and individuals should be able to respond to global regulations as support for faith and perspective to continue to live and fill the days ahead with the maximum quality of life as prime human beings. ABSTRAK: Antropologi kesehatan mengalami suatu revolusi baru yang dahsyat, dimulai dari tahun lalu, 2020. Sebuah rumusan Protokol Kesehatan New-normal diberlakukan untuk menangani wabah pandemi Covid-19. Masyarakat nyata dan media sosial mengeluhkan perasaan degradasi kemanusiaan dan hak asasi manusia bahkan mencuatkan seruan perlawanan karena peraturan pembatasan global yang dipaksakan. Allah dalam teologi Kristen adalah Allah yang berjanji kepada manusia ciptaan-Nya bahwa Ia akan menyertai dan menolong manusia untuk mendapatkan kehidupan yang sejahtera dan berbahagia. Dengan melakukan sebuah literature-research tulisan ini mencoba menelusuri apakah pedoman tatalaksana Covid-19 ini sesuai dengan konsistensi Allah yang berjanji dalam hal memulihkan esensi kemanusiaan. Bagaimanakah hubungan antara dua paradigma tentang kemanusiaan dari sisi Allah dan manusia melalui intervensi Protokol Kesehatan. Temuan bahwa Allah yang menciptakan manusia yang sempurna menjaga sepanjang proses kehidupannya agar menjadi umat kerajaan kekal-Nya. Seyogyanya masyarakat dan individu dapat menyikapi peraturan global sebagai penopang iman dan cara pandang sehingga tetap dapat menjalani dan mengisi hari-hari ke depan dengan kualitas hidup maksimal sebagai manusia prima.

The Microbiome as a Potential Target for Therapeutic Manipulation in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and is projected to be the second most common cause of cancer-related death by 2030, with an overall 5-year survival rate between 7% and 9%. Despite recent advances in surgical, chemotherapy, and radiotherapy techniques, the outcome for patients with PDAC remains poor. Poor prognosis is multifactorial, including the likelihood of sub-clinical metastatic disease at presentation, late-stage at presentation, absence of early and reliable diagnostic biomarkers, and complex biology surrounding the extensive desmoplastic PDAC tumour micro-environment. Microbiota refers to all the microorganisms found in an environment, whereas microbiome is the collection of microbiota and their genome within an environment. These organisms reside on body surfaces and within mucosal layers, but are most abundantly found within the gut. The commensal microbiome resides in symbiosis in healthy individuals and contributes to nutritive, metabolic and immune-modulation to maintain normal health. Dysbiosis is the perturbation of the microbiome that can lead to a diseased state, including inflammatory bowel conditions and aetiology of cancer, such as colorectal and PDAC. Microbes have been linked to approximately 10% to 20% of human cancers, and they can induce carcinogenesis by affecting a number of the cancer hallmarks, such as promoting inflammation, avoiding immune destruction, and microbial metabolites can deregulate host genome stability preceding cancer development. Significant advances have been made in cancer treatment since the advent of immunotherapy. The microbiome signature has been linked to response to immunotherapy and survival in many solid tumours. However, progress with immunotherapy in PDAC has been challenging. Therefore, this review will focus on the available published evidence of the microbiome association with PDAC and explore its potential as a target for therapeutic manipulation.

LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?

Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 women. The majority of these tend to be associated with a poor prognosis. Long non-coding RNAs (lncRNAs) play a critical role in the normal development of organisms as well as in tumorigenesis. LncRNAs can be classified into tumor suppressor genes or oncogenes, depending on their function within the cellular context and the signaling pathways in which they are involved. These regulatory RNAs are potential therapeutic targets for cancer due to their tissue and tumor specificity. However, there still needs to be a deeper understanding of the mechanisms by which lncRNAs are involved in the regulation of numerous biological functions in humans, both in normal health and disease. The lncRNA Mortal Obligate RNA Transcript (MORT; alias ZNF667-AS1) has been identified as a tumor-related lncRNA. ZNF667-AS1 gene, located in the human chromosome region 19q13.43, has been shown to be silenced by DNA hypermethylation in several cancers. In this review, we report on the biological functions of ZNF667-AS1 from recent studies and describe the regulatory functions of ZNF667-AS1 in human disease, including cancer. Furthermore, we discuss the emerging insights into the potential role of ZNF667-AS1 as a biomarker and novel therapeutic target in cancer, including GCs (ovarian, cervical, and endometrial cancers).

Reference Intervals for Selected Hematology and Clinical Chemistry Measurands in Temminck's Pangolin (Smutsia temminckii)

Pangolins are the world's most trafficked non-human mammals. A significant number of Temminck's pangolins (Smutsia temminckii) are presented for veterinary care and rehabilitation in southern Africa. Little is known about the physiology and normal health of this species, making diagnosis and medical management difficult. This study aimed to establish reference intervals (RIs) for hematology and plasma clinical chemistry in the Temminck's pangolin. RIs were generated according to international guidelines using samples from 27 healthy free-living (n = 18) and rehabilitated (n = 9) pangolins. Hematology was performed using the Abaxis VetScan HM5 analyzer with manual differentials; clinical chemistry was performed using heparin plasma on the Abaxis VetScan VS2 and Cobas Integra 400 Plus analyzers. Hematology RIs were: RBC 3.88–8.31 × 1012/L, HGB 73–150 g/L, HCT 26–51%, MCV 59–72 fL, MCH 15.6–21.4 pg, MCHC 257–325 g/L, RDW 14.3–19.1%, WBC 1.80–10.71 × 109/L. Vetscan VS2 clinical chemistry RIs were: albumin 27–41 g/L, ALP 26–100 U/L, ALT 25–307 U/L, amylase 267–826 U/L, bilirubin 4–10 μmol/L, calcium 2.1–2.2 mmol/L, globulin 21–55 g/L, glucose 3.8–10.0 mmol/L, phosphate 1.3–2.6 mmol/L, potassium 3.6–5.9 mmol/L, sodium 132–140 mmol/L total protein 52–84 g/L, and urea 5.3–11.4 mmol/L. RIs for creatinine were not calculated as analytical imprecision exceeded analytical performance goals. Cobas Integra clinical chemistry RIs were: albumin 22–33 g/L, ALP 20–104 U/L, ALT 17–291 U/L, amylase 466–1,533 U/L, bilirubin 1–14 μmol/L, calcium 2.0–2.4 mmol/L, creatinine &lt;58 μmol/L, globulin 23–49 g/L, glucose 3.6–10.1 mmol/L, phosphate 1.0–2.2 mmol/L, potassium 3.1–5.8 mmol/L, sodium 137–150 mmol/L, total protein 47–72 g/L, and urea 6.0–12.5 mmol/L. There was significant bias between the two chemistry analyzers for several measurands. Differences were found for some analytes between free-living and rehabilitated animals, probably reflecting differences in nutrition and hydration. These are the first RIs generated for Temminck's pangolin. These results will allow veterinarians to better determine pangolin health status, formulate optimal treatment plans and increase patient survival rates in this endangered species.

Hematological and biochemical profile of spider monkey (Ateles geoffroyi) in captivity

Objective: To estimate the hematological and biochemical reference values inMAteles geoffroyi individuals in captivity. Methodology: Eleven males and 23 females were captured. We collected blood,from the coccygian vein; conventional techniques were used to analyze thesamples.Results: mean corpuscular volume (MCV; P &lt; 0.03), platelets (PLT; P &lt; 0.04) were significantly higher in females than in males. In relation to biochemical blood values wasn’t significantly in male and female groups.Limitations/Implications: hematological and biochemical reference values of A. geoffroyi are within normal health parameters, are between the ranges reported for other species of neotropical primates and can be used as a reference in for the management of the health of this species in captivity.Conclusions: hematological and biochemical parameters of captive specimens of A. geoffroyi are described, which provide reference indicators for the management of the health of the species.

Reasons for Exclusion of Apparently Healthy Mature Adult and Senior Dogs From a Clinical Trial

Background: Interventional clinical trials intended to maintain health in aging dogs are unusual and require particular attention to exclusion criteria.Objectives: To describe reasons for exclusion when a mature adult and senior canine population with normal health status was sought.Animals: Fifty six companion dogs nominated for a randomized controlled trial (RCT).Procedures: Exclusions occurred within Stage 1 (S1): owner-provided survey information; Stage 2 (S2): medical records review; and Stage 3 (S3): screening examination and within Owner, Dog, or Other factor categories.Results: Of 56 nominated dogs, 39 were excluded at S1 (n = 19), S2 (n = 5), and S3 (n = 15), respectively. Dogs were excluded for Owner (n = 4), Dog (n = 27), Other (n = 6), and concurrent (Owner + Dog; n = 2) factors. The most common exclusion period was S1 (n = 19), with weight outside the target range being the most common exclusion factor in that stage (n = 10). Heart murmurs were the second most common exclusion factor (S1: n = 1; S3: n = 5); suspected or confirmed systemic illness was third most common (S1: n = 2; S2: n = 3; S3: n = 2). Among dogs who passed S1 and S2 screening (n = 32), 15 dogs (48%) were excluded at S3, for heart murmur &gt; grade II/VI (n = 5), cardiac arrhythmias (n = 2), and clinicopathologic abnormalities (n = 2).Conclusions and Clinical Relevance: Dogs nominated for a clinical trial for healthy mature adult and senior dogs were excluded for size, previous diagnoses, and newly discovered cardiac abnormalities. For future interventions in mature adult and senior dogs of normal health status, it is important to define expected age-related abnormalities to ensure that meaningful exclusion criteria are used.

Design of New Normal Health Protocol Reminder Using Arduino Nano and Ultrasonic Sensor

Corona virus is a group of viruses that can cause disease in animals or humans. The most common symptoms of COVID-19 are fever, dry cough and feeling tired. Other symptoms that some patients may experience less often include aches and pains, nasal congestion, headache, conjunctivitis, sore throat, diarrhea, loss of taste or smell, rash on the skin, or discoloration of fingers or toes. The Indonesian government urges the public to maintain productivity even in the midst of the ongoing corona virus pandemic with a new order called the new normal, namely by implementing health protocols. PGRI Adi Buana University Surabaya is one of the places where many people do their activities and gather. The existence of this gathering activity can increase the risk of transmitting COVID-19. To prevent transmission, every academic community must always apply the new normal health protocol as recommended by the government, such as wearing masks, washing hands with soap, and maintaining social distancing. So far, health protocol surveillance activities in the campus environment have only relied on the role of security so that it is less effective considering the limited human ability, so a tool is needed to always remind in implementing the new normal health protocol. The tool is in the form of audio using the Ultrasonic HC-SR04 and Arduino Nano sensors. So every object that passes through the sensor will be processed by a microcontroller (Arduino Nano) and then processed into an output in the form of a buzzer. The buzzer that comes out is a voice to remind everyone in the university to implement health protocols.