Validation of the Reflux Disease Questionnaire for a Turkish Population

Background and Aims: Achieving the correct diagnosis and therapeutic success in gastroesophageal reflux disease (GERD) depends on the patient‘s self-assessment. Therefore, valid and reliable patient-reported questionnaires are very important. When designing such measurement tools, researchers should focus on their validity, reliability, sensitivity, and, applicability. The reflux disease questionnaire (RDQ) largely meets these important requirements. This study aims to examine The RDQ’s psychometric characteristics for the Turkish society (RDQ TR ) and its validity in symptoms’ evaluation. Methods: The sample of this study comprised 81 patients who were admitted to our institution, GERD study group outpatient clinic. The data collection forms used in the study were the case report forms and RDQ. Three weeks after the first interview, 30 patients were re-interviewed by the phone and the RDQ was re-administered. For the validity studies of the scale, language validity, content validity, and construct validity studies were used, and for the reliability studies, internal consistency and test-retest reliability methods were used. Results: The content validity index of form was 0.95 (0.93-0.98). The performed factor analysis indicated 3 factors with an eigenvalue over 1.0. Those factors were responsible for 77.66% of the variance. The Cronbach‘s alpha values were 0.88 for regurgitation sub-dimension, 0.91 for dyspepsia sub-dimension, 0.86 for heartburn sub-dimension, and 0.92 overall. Intraclass correlation coefficient value of the scale was 0.94. Conclusions: Our study highlights that the RDQ TR is reliable, valid, and responsive to change in Turkey patients with GERD symptomatology.

HUBUNGAN POLA MAKAN DENGAN TERJADINYA GASTROESOPHAGEAL REFLUX DISEASE (GERD)

Latar Belakang : Gastroesophageal Reflux Disease (GERD) merupakan penyakit kronik yang terjadi pada masyarakat dewasa terutama mahasiswa. Faktor yang dapat menyebabkan GERD adalah pola makan termasuk jenis-jenis makanan tertentu yang dikonsumsi, frekuensi makan, dan ketidakteraturan makan. Mahasiswa kedokteran selalu berada di bawah tekanan akademik sehingga muncul ketidaknyamanan pencernaan yang memberi dampak bagi kualitas hidup dan aktivitas sehari-hari. Tujuan : Mengetahui hubungan pola makan dengan terjadinya Gastroesophageal Reflux Disease (GERD) pada mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Syiah Kuala. Metode : Penelitian ini merupakan penelitian deskriptif analitik observasional dengan desain cross sectional. Teknik pengambilan sampel yang digunakan adalah stratified random sampling sebanyak 216 subjek yang memenuhi kriteria inklusi. Pengumpulan data diperoleh dari hasil pengisian kuesioner oleh subjek menggunakan kuesioner pola makan yang sudah divalidasi dan dimodifikasi oleh peneliti dan menggunakan Gastroesophageal Reflux Disease Questionnaire (GERDQ) dalam bahasa Indonesia yang telah valid. Kuesioner pola makan dinilai dari segi keteraturan makan, frekuensi makan, jenis-jenis makanan, dan porsi makanan yang dikonsumsi. Hasil : Subjek yang memiliki pola makan buruk dan mengalami GERD sebanyak 34,2% sedangkan subjek yang memiliki pola makan baik dan tidak mengalami GERD sebanyak 86,5%. Analisis data dilakukan dengan menggunakan uji Chi Square. Hasil analisis data menunjukkan terdapat hubungan antara pola makan dengan terjadinya Gastroesophageal Reflux Disease (GERD) (p = 0,004).Simpulan : Terdapat hubungan antara pola makan dengan terjadinya Gastroesophageal Reflux Disease (GERD) pada mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Syiah Kuala.

Dexlansoprazole is Effective in Relieving Heartburn during the Fasting Month of Ramadan

Background and Aims: Proton pump inhibitors are effective at reducing heartburn. No studies have evaluated their efficacy in Ramadan. Dexlansoprazole has a unique active formulation independent of time-of-day dosing or food. The aim is to investigate the efficacy of dexlansoprazole 60 mg during Ramadan in patients with symptomatic heartburn. Methods: Subjects recruited using poster, radio, and SMS advertisements completed a diary using a mobile-friendly application and received daily SMS reminders. Dexlansoprazole was started on day 8 for 3 weeks. No placebo arm was used in this trial. Primary endpoint was relief of heartburn expressed as mean 24-h free heartburn percentage (24FH%) per weekly period. Results: A total of 32 patients were enrolled. During week 1, only 1 person (3.1%) was heartburn-free and mean 24FH% was 41.1 ± 24.8%. On dexlansoprazole, mean 24FH% rose to 63.4 ± 23.8 and 81.6 ± 24.5% in weeks 2 and 4, respectively (p < 0.001 for both). Median 24FH% increased from 35.7% in week 1 to 71.4 and 85.7% in weeks 2 and 4, respectively. Mean Gastroesophageal Reflux Disease Questionnaire (GERDQ) scores decreased from 10.0 ± 3.2 in week 1 to 6.53 ± 2.2 in week 2 (p < 0.001) and 5.87 ± 2.1 in week 4 (p < 0.001). Mean heartburn severity score decreased from 2.5 ± 1.0 to 1.7 ± 0.8 (p = 0.001). Early response was higher in patients with GERDQ scores ≥8 (p = 0.012). Conclusion: Dexlansoprazole is effective in the treatment of heartburn during Ramadan. Clinicaltrials.gov number: NCT03079050.