scholarly journals Corrigendum to “Ameliorative Effect of Saffron Aqueous Extract on Hyperglycemia, Hyperlipidemia, and Oxidative Stress on Diabetic Encephalopathy in Streptozotocin Induced Experimental Diabetes Mellitus”

2020 ◽  
Vol 2020 ◽  
pp. 1-1
Author(s):  
BioMed Research International
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Aqueous Extract ◽  
Experimental Diabetes ◽  
Diabetic Encephalopathy ◽  
Experimental Diabetes Mellitus ◽  
Ameliorative Effect ◽  
And Oxidative Stress

scholarly journals Ameliorative Effect of Saffron Aqueous Extract on Hyperglycemia, Hyperlipidemia, and Oxidative Stress on Diabetic Encephalopathy in Streptozotocin Induced Experimental Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Saeed Samarghandian ◽  
Mohsen Azimi-Nezhad ◽  
Fariborz Samini
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Serum Proteins ◽  
Advanced Glycation Endproducts ◽  
Antioxidant Properties ◽  
Diabetic Encephalopathy ◽  
Beneficial Effects ◽  
Glucose Levels ◽  
Ameliorative Effect ◽  
Saffron Extract

Diabetic encephalopathy is one of the severe complications in patients with diabetes mellitus. Findings indicate that saffron extract has antioxidant properties but its underlying beneficial effects on diabetic encephalopathy were unclear. In the present study, the protective activities of saffron were evaluated in diabetic encephalopathy. Saffron at 40 and 80 mg/kg significantly increased body weight and serum TNF-αand decreased blood glucose levels, glycosylated serum proteins, and serum advanced glycation endproducts (AGEs) levels. Furthermore, significant increase in HDL and decrease (P<0.05) in cholesterol, triglyceride, and LDL were observed after 28 days of treatment. At the end of experiments, the hippocampus tissue was used for determination of glutathione content (GSH), superoxide dismutase (SOD), and catalase (CAT) activities. Furthermore, saffron significantly increased GSH, SOD, and CAT but remarkably decreased cognitive deficit, serum TNF-α, and induced nitric oxide synthase (iNOS) activity in hippocampus tissue. Our findings indicated that saffron extract may reduce hyperglycemia and hyperlipidemia risk and also reduce the oxidative stress in diabetic encephalopathy rats. This study suggested that saffron extract might be a promising candidate for the improvement of chemically induced diabetes and its complications.

scholarly journals Curcumin and Its Analog Alleviate Diabetes-induced Damages by Regulating Inflammation and Oxidative Stress in Brain of Diabetic Rats​

2020 ◽  
Author(s):  
Chengfeng Miao ◽  
Hanbin Chen ◽  
Yulian Li ◽  
Ying Guo ◽  
Feifei Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Western Blot ◽  
Diabetic Rats ◽  
High Dose ◽  
Diabetic Encephalopathy ◽  
Sprague Dawley ◽  
The Brain ◽  
And Oxidative Stress ◽  
Myelin Staining

Abstract Background: Diabetic encephalopathy is a severe diabetes complication with cognitive dysfunction and neuropsychiatric disability. The mechanisms underlying diabetic encephalopathy is believed to be relevant with oxidative stress, vascular amylin deposition, immune receptors, inflammation, etc. This study wanted to evaluate the ability of curcumin and its analog A13 to alleviate oxidative stress and inflammation in diabetes-induced damages in brain.Methods: Sixty adult male Sprague-Dawley rats were divided into 5 groups: normal control (NC) group, diabetes mellitus (DM) group, curcumin-treated diabetes mellitus (CUR) group, high dose of A13-treated diabetes mellitus (HA) group, low dose of A13-treated diabetes mellitus (LA) group. Activation of the nuclear factor kappa-B (NF-κB p65) pathway was detected by RT-qPCR, immunohistochemical (IHC) staining and Western blot; oxidative stress was detected by biochemical detection kit; brain tissue sections were stained with hematoxylin–eosin (HE) staining and Myelin staining. Results: RT-qPCR, IHC staining and Western blot showed that curcumin and A13 treatment could inhibit the NF-κB p65 pathway. Curcumin and A13 increased the activity of superoxide dismutase and decreased the malondialdehyde level in the brain of diabetic rats. Furthermore, HE staining and Myelin staining demonstrated that the histological lesions of the brain in diabetic rats could be significantly ameliorated by curcumin and A13.Conclusion: Curcumin analog A13 could alleviate the damages in the brain of diabetes rats by regulating the pathways of inflammation and oxidative stress. A13 may be a new potential therapeutic agent for diabetic encephalopathy.

The effect of melatonin on oxidative stress and apoptosis in experimental diabetes mellitus-related ovarian injury

2016 ◽  
Vol 32 (5) ◽  
pp. 421-426 ◽  
Author(s):  
Umit Nayki ◽  
Didem Onk ◽  
Gurhan Balci ◽  
Cenk Nayki ◽  
Alper Onk ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Experimental Diabetes ◽  
Experimental Diabetes Mellitus
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