scholarly journals Etiology, Clinical Features, and Diagnosis of Vulvar Lichen Sclerosus: A Scoping Review

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Nilanchali Singh ◽  
Prafull Ghatage
Keyword(s):  
Clinical Features ◽  
Scoping Review ◽  
English Language ◽  
Lichen Sclerosus ◽  
Published Data ◽  
Inflammatory Disorder ◽  
Lichen Sclerosus Et Atrophicus ◽  
Chronic Inflammatory Disorder ◽  
Study Selection ◽  
Vulvar Lichen Sclerosus

Objective. Vulvar lichen sclerosus (VLS) is a chronic inflammatory disorder, which affects women of all ages. With numerous controversies as regards to the nomenclature, diagnosis and its association with neoplastic conditions, we decided to conduct a scoping review on this subject. Data Source. A review protocol was developed, and the Knowledge Resource Services website was used to do a search of articles pertaining to VLS with keywords “Vulvar,” “Vulval,” “diagnosis,” “lichen sclerosus et atrophicus,” “kraurosis,” “vulvar dystrophy,” and “Lichen Sclerosus”. Study Selection. The search was limited to published data from the last ten years, i.e., from July 2009 onwards and in the English language. A total of 338 articles pertaining to VLS were obtained. Older data were accessed if particular information was sought for. Results & Conclusion. The presentation is bimodal, i.e., one in prepubertal girls (average age: 7.6 years) and the other in peri- and postmenopausal women (average age: 52.6 years). However, many cases also present during reproductive years. Studies suggest a multifactorial origin as far as etiology is concerned, including a genetic, autoimmune, hormonal, and local infectious background. It affects the genital labial, perineal, and perianal areas and manifests as a patchy, thin, glistening, ivory-white area. Diagnosis is mainly based on clinical features. Biopsy is seldom required. It has been well established as a precursor lesion of dVIN and vulvar carcinoma.

Eosinophilic chronic rhinosinusitis and concurrent Kimura’s disease treated with mepolizumab

2021 ◽  
Vol 14 (1) ◽  
pp. e232627
Author(s):  
Jacqueline Ho ◽  
Sophie Walter ◽  
Richard J Harvey
Keyword(s):  
English Language ◽  
Cervical Lymphadenopathy ◽  
Upper Airway ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder ◽  
First Case ◽  
Eosinophilic Chronic Rhinosinusitis

Kimura’s disease is a rare, benign, chronic inflammatory disorder characterised by its eosinophilic infiltrate. Patients often present with one or more progressively enlarging subcutaneous lymph nodes in the head and neck region or enlarging salivary glands. We describe the case of a 26-year-old man presenting with severe peripheral eosinophilia and upper airway inflammatory symptoms, who later developed cervical lymphadenopathy and formally diagnosed with Kimura’s disease. Based on our English-language MEDLINE literature search, to our knowledge this is the first case report describing treatment of Kimura’s disease with mepolizumab.

scholarly journals Immunohistochemical Evidence of Skin Immune System Involvement in Vulvar Lichen sclerosus et atrophicus

Dermatology ◽  
1991 ◽  
Vol 182 (1) ◽  
pp. 18-22 ◽  
Author(s):  
P. Carli ◽  
A. Cattaneo ◽  
N. Pimpinelli ◽  
A. Cozza ◽  
G. Bracco ◽  
...  
Keyword(s):  
Immune System ◽  
Lichen Sclerosus ◽  
Lichen Sclerosus Et Atrophicus ◽  
System Involvement ◽  
Skin Immune System ◽  
Immunohistochemical Evidence ◽  
Vulvar Lichen Sclerosus

scholarly journals Lichen Sclerosus Atrophicus [LSA] in the Areolae: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
L. Padmavathy ◽  
L. Lakshmana Rao ◽  
M. Dhana Lakshmi ◽  
N. Sylvester ◽  
N. Ethirajan
Keyword(s):  
Case Report ◽  
Lichen Sclerosus ◽  
Inflammatory Disorder ◽  
Unknown Aetiology ◽  
Chronic Inflammatory Disorder ◽  
Anogenital Area

Lichen sclerosus (LS) is a chronic inflammatory disorder of an unknown aetiology most commonly affecting the anogenital area. However, extragenital involvement also occurs uncommonly. A case of extra-genital LS involving the areolae of both breasts, in a 15-year-old boy, is reported for its rarity.

scholarly journals Interventions to Mitigate COVID-19 Misinformation: Protocol for a Scoping Review

2021 ◽  
Author(s):  
Navin Kumar ◽  
Nathan Walter ◽  
Kate Nyhan ◽  
Kaveh Khoshnood ◽  
Joseph D Tucker ◽  
...  
Keyword(s):  
Systematic Review ◽  
Scoping Review ◽  
English Language ◽  
Current Knowledge ◽  
Grey Literature ◽  
Open Science ◽  
Original Research ◽  
Study Selection ◽  
Scoping Reviews ◽  
Science Framework

Abstract Background: The duration and impact of the COVID-19 pandemic depends in a large part on individual and societal actions which is influenced by the quality and salience of the information to which they are exposed. Unfortunately, COVID-19 misinformation has proliferated. To date, no systematic efforts have been made to evaluate interventions that mitigate COVID-19-related misinformation. We plan to conduct a scoping review that seeks to fill several of the gaps in the current knowledge of interventions that mitigate COVID-19-related misinformation.Methods: A scoping review focusing on interventions that mitigate COVID-19 misinformation will be conducted. We will search (from January 2020 onwards) MEDLINE, EMBASE, CINAHL, PsycINFO, Web of Science Core Collection, Africa-Wide Information, Global Health, WHO Global Literature on Coronavirus Disease Database, WHO Global Index Medicus, and Sociological Abstracts. Grey literature will be identified using Disaster Lit, Google Scholar, Open Science Framework, governmental websites and preprint servers (e.g. EuropePMC, PsyArXiv, MedRxiv, JMIR Preprints). Study selection will conform to Joanna Briggs Institute Reviewers’ Manual 2020 Methodology for JBI Scoping Reviews. Only English language, original studies will be considered for inclusion. Two reviewers will independently screen all citations, full-text articles, and abstract data. A narrative summary of findings will be conducted. Data analysis will involve quantitative (e.g. frequencies) and qualitative (e.g. content and thematic analysis) methods.Discussion: Original research is urgently needed to design interventions to mitigate COVID-19 misinformation. The planned scoping review will help to address this gap.Systematic Review registrations: Systematic Review Registration: Open Science Framework (osf/io/etw9d).

scholarly journals Vulvar Lichen Sclerosus et Atrophicus in girls

2021 ◽  
Vol 24 (5) ◽  
pp. 356-360
Author(s):  
Leila V. Adamyan ◽  
Sergey M. Sharkov ◽  
Elena V. Sibirskaya ◽  
Laura G. Pivazyan ◽  
Julietta S. Avetisyan
Keyword(s):  
Randomized Clinical Trials ◽  
Clinical Symptoms ◽  
Case Series ◽  
Lichen Sclerosus ◽  
Genetic Mutations ◽  
Lichen Sclerosus Et Atrophicus ◽  
Inflammatory Dermatosis ◽  
Anogenital Region ◽  
Literature Reviews ◽  
Vulvar Lichen Sclerosus

The review is devoted to diagnosing and treating lichen sclerosus (LS), a chronic inflammatory dermatosis with a predisposition to lesions of the anogenital region in girls. An essential role in the aetiology of this form of pathology is attributed to genetic mutations, injuries, infections and autoimmune diseases, and hormonal and local factors. The peak incidence is observed in 4-6 year girls, accounting for 7-15% of all cases of vulvar LS. The main goal of pharmacotherapy for vulvar LS is to relieve clinical symptoms and prevent scarring and adhesions. The authors analyzed international and domestic publications from 2017 to 2021. PubMed and Google Academy databases were used for the search, keywords: lichen sclerosus, girls. The retrospective and prospective cohort, randomized clinical trials, case series and literature reviews, and clinical guidelines were considered. Our review presents modern data on the diagnosis and treatment of SL in girls, which will be useful for both pediatric gynecologists and doctors of related specialties. The first symptoms of LS are usually nonspecific and are misdiagnosed by non-profile specialists. Some symptoms of LS may disappear spontaneously after menarche, and the course of the disease may be latent. This is why it is generally accepted that the epidemiology of LS is underestimated. Despite this, it can be assumed that the etiology and pathogenesis of LS is probably multifactorial. This review describes several leading etiological factors regarding the potential etiopathogenesis of vulvar LS in girls.

scholarly journals Treatment Options in Vulvar Lichen Sclerosus: A Scoping Review

Cureus ◽  
2021 ◽  
Author(s):  
Nilanchali Singh ◽  
Neha Mishra ◽  
Prafull Ghatage
Keyword(s):  
Scoping Review ◽  
Treatment Options ◽  
Lichen Sclerosus ◽  
Vulvar Lichen Sclerosus
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