scholarly journals Immunohistochemical Evidence of Skin Immune System Involvement in Vulvar Lichen sclerosus et atrophicus

Dermatology ◽  
1991 ◽  
Vol 182 (1) ◽  
pp. 18-22 ◽  
Author(s):  
P. Carli ◽  
A. Cattaneo ◽  
N. Pimpinelli ◽  
A. Cozza ◽  
G. Bracco ◽  
...  
Keyword(s):  
Immune System ◽  
Lichen Sclerosus ◽  
Lichen Sclerosus Et Atrophicus ◽  
System Involvement ◽  
Skin Immune System ◽  
Immunohistochemical Evidence ◽  
Vulvar Lichen Sclerosus

scholarly journals Vulvar Lichen Sclerosus et Atrophicus in girls

2021 ◽  
Vol 24 (5) ◽  
pp. 356-360
Author(s):  
Leila V. Adamyan ◽  
Sergey M. Sharkov ◽  
Elena V. Sibirskaya ◽  
Laura G. Pivazyan ◽  
Julietta S. Avetisyan
Keyword(s):  
Randomized Clinical Trials ◽  
Clinical Symptoms ◽  
Case Series ◽  
Lichen Sclerosus ◽  
Genetic Mutations ◽  
Lichen Sclerosus Et Atrophicus ◽  
Inflammatory Dermatosis ◽  
Anogenital Region ◽  
Literature Reviews ◽  
Vulvar Lichen Sclerosus

The review is devoted to diagnosing and treating lichen sclerosus (LS), a chronic inflammatory dermatosis with a predisposition to lesions of the anogenital region in girls. An essential role in the aetiology of this form of pathology is attributed to genetic mutations, injuries, infections and autoimmune diseases, and hormonal and local factors. The peak incidence is observed in 4-6 year girls, accounting for 7-15% of all cases of vulvar LS. The main goal of pharmacotherapy for vulvar LS is to relieve clinical symptoms and prevent scarring and adhesions. The authors analyzed international and domestic publications from 2017 to 2021. PubMed and Google Academy databases were used for the search, keywords: lichen sclerosus, girls. The retrospective and prospective cohort, randomized clinical trials, case series and literature reviews, and clinical guidelines were considered. Our review presents modern data on the diagnosis and treatment of SL in girls, which will be useful for both pediatric gynecologists and doctors of related specialties. The first symptoms of LS are usually nonspecific and are misdiagnosed by non-profile specialists. Some symptoms of LS may disappear spontaneously after menarche, and the course of the disease may be latent. This is why it is generally accepted that the epidemiology of LS is underestimated. Despite this, it can be assumed that the etiology and pathogenesis of LS is probably multifactorial. This review describes several leading etiological factors regarding the potential etiopathogenesis of vulvar LS in girls.

scholarly journals Etiology, Clinical Features, and Diagnosis of Vulvar Lichen Sclerosus: A Scoping Review

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Nilanchali Singh ◽  
Prafull Ghatage
Keyword(s):  
Clinical Features ◽  
Scoping Review ◽  
English Language ◽  
Lichen Sclerosus ◽  
Published Data ◽  
Inflammatory Disorder ◽  
Lichen Sclerosus Et Atrophicus ◽  
Chronic Inflammatory Disorder ◽  
Study Selection ◽  
Vulvar Lichen Sclerosus

Objective. Vulvar lichen sclerosus (VLS) is a chronic inflammatory disorder, which affects women of all ages. With numerous controversies as regards to the nomenclature, diagnosis and its association with neoplastic conditions, we decided to conduct a scoping review on this subject. Data Source. A review protocol was developed, and the Knowledge Resource Services website was used to do a search of articles pertaining to VLS with keywords “Vulvar,” “Vulval,” “diagnosis,” “lichen sclerosus et atrophicus,” “kraurosis,” “vulvar dystrophy,” and “Lichen Sclerosus”. Study Selection. The search was limited to published data from the last ten years, i.e., from July 2009 onwards and in the English language. A total of 338 articles pertaining to VLS were obtained. Older data were accessed if particular information was sought for. Results & Conclusion. The presentation is bimodal, i.e., one in prepubertal girls (average age: 7.6 years) and the other in peri- and postmenopausal women (average age: 52.6 years). However, many cases also present during reproductive years. Studies suggest a multifactorial origin as far as etiology is concerned, including a genetic, autoimmune, hormonal, and local infectious background. It affects the genital labial, perineal, and perianal areas and manifests as a patchy, thin, glistening, ivory-white area. Diagnosis is mainly based on clinical features. Biopsy is seldom required. It has been well established as a precursor lesion of dVIN and vulvar carcinoma.

A case of large squamous cell carcinoma raised on vulvar lichen sclerosus et atrophicus

Skin Cancer ◽  
2010 ◽  
Vol 25 (1) ◽  
pp. 90-93
Author(s):  
Yusuke NIWA ◽  
Toshio HASEGAWA ◽  
Ryoko SYUKUYA ◽  
Keiko OKUMA ◽  
Yusuke HIRASAWA ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lichen Sclerosus ◽  
Lichen Sclerosus Et Atrophicus ◽  
Vulvar Lichen Sclerosus
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