scholarly journals Stability of Alkaloids during Drying Process and Their Effect on Anticoagulating Activity of Uncariae Ramulus Cum Uncis

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Lu Zou ◽  
Fengyu Lu ◽  
Bing Lin ◽  
Ying Zhou ◽  
Tingting Liu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Constant Temperature ◽  
Herbal Medicines ◽  
Procoagulant Activity ◽  
Drying Process ◽  
Coagulation Time ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

The drying process of Uncariae Ramulus Cum Uncis (URCU), a kind of traditional Chinese medicine, was studied in a scale dryer in laboratory at 65°C. It was observed that the alkaloids content of URCU firstly showed a tendency of increasing and then decreasing after reaching the peak at the 570th minute in the process of constant temperature drying. Moreover, the coagulation time of rabbit determined by test tubes has been adopted to study the effect imposed by the content of alkaloids on the anticoagulating activity of URCU. In addition, the software of Minitab was also utilized to fit the correlation between the content of alkaloids and the anticoagulating activity of URCU. The results obtained demonstrated that anticoagulant activities were available in both rhynchophylline and isorhynchophylline, among which the latter was the stronger one, while procoagulant activity was shown in corynoxeine. The case study can provide a useful reference for the research on drying other Chinese herbal medicines (CHMs) and further study on URCU.

scholarly journals Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update

2021 ◽  
Vol 12 ◽  
Author(s):  
Wei Zhuang ◽  
Shaoli Liu ◽  
Xusheng Zhao ◽  
Nan Sun ◽  
Tao He ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Literature Search ◽  
Herbal Medicines ◽  
Anticoagulant Effect ◽  
Therapeutic Window ◽  
Cochrane Library ◽  
Clinical Use ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

Background: Warfarin is a commonly used oral anticoagulant. It has a narrow therapeutic window and wide variation in individualized dosing, and is used clinically for the treatment of thromboembolic diseases. Due to the widespread use of traditional Chinese medicine (TCM) in China and the complex composition and diverse mechanisms of action of TCM, the combination of TCM and warfarin in patients has led to fluctuations in the international normalized ratio of warfarin or bleeding. To ensure rational clinical use, we summarize the TCMs with which warfarin interacts and the possible mechanisms, with a view to providing a clinical reference.Aim of the study: To summarize the mechanisms by which Chinese herbal medicines affect the enhancement or weakening of the anticoagulant effect of warfarin, to provide theoretical references for clinicians and pharmacists to use warfarin safely and rationally, and to avoid the adverse effects associated with the combination of Chinese herbal medicines and warfarin.Methods: A computerized literature search of electronic databases, including PubMed, MEDLINE, Cochrane Library, Web of Science (WOS), China National Knowledge Infrastructure (CNKI) and WANFANG Data was performed. Key words used in the literature search were “warfarin”, “Chinese medicine”, “traditional Chinese medicine”, “Chinese patent medicine” etc. and their combinations in a time limit from January 1, 1990 to May 1, 2021. A total of 64 articles were obtained following the selection process, including clinical reports, pharmacological experiments and in vitro experiments which were reviewed to determine the mechanism of the anticoagulant effect of herbal medicine on warfarin.Results: The mechanisms affecting the anticoagulant effect of warfarin are complex, and herbal medicines may enhance and diminish the anticoagulant effect of warfarin through a variety of mechanisms; thus, clinical use needs to be cautious. Some herbal medicines have shown inconsistent results in both in vivo and ex vivo experiments, pharmacology and clinical studies, and should be the focus of future research.Conclusion: With the widespread use of TCM, the combination of warfarin and TCM is more common. This article will promote clinicians’ knowledge and understanding of the TCMs which interact with warfarin, in order to avoid the occurrence of adverse clinical treatment processes, and improve the efficacy and safety.

scholarly journals To Set Up a Logistic Regression Prediction Model for Hepatotoxicity of Chinese Herbal Medicines Based on Traditional Chinese Medicine Theory

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Hongjie Liu ◽  
Tianhao Li ◽  
Lingxiu Chen ◽  
Sha Zhan ◽  
Meilan Pan ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Prediction Model ◽  
Herbal Medicines ◽  
Chi Square ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Chi Square Test ◽  
Set Up

Aims. To establish a logistic regression (LR) prediction model for hepatotoxicity of Chinese herbal medicines (HMs) based on traditional Chinese medicine (TCM) theory and to provide a statistical basis for predicting hepatotoxicity of HMs.Methods. The correlations of hepatotoxic and nonhepatotoxic Chinese HMs with four properties, five flavors, and channel tropism were analyzed with chi-square test for two-way unordered categorical data. LR prediction model was established and the accuracy of the prediction by this model was evaluated.Results. The hepatotoxic and nonhepatotoxic Chinese HMs were related with four properties (p<0.05), and the coefficient was 0.178 (p<0.05); also they were related with five flavors (p<0.05), and the coefficient was 0.145 (p<0.05); they were not related with channel tropism (p>0.05). There were totally 12 variables from four properties and five flavors for the LR. Four variables, warm and neutral of the four properties and pungent and salty of five flavors, were selected to establish the LR prediction model, with the cutoff value being 0.204.Conclusions. Warm and neutral of the four properties and pungent and salty of five flavors were the variables to affect the hepatotoxicity. Based on such results, the established LR prediction model had some predictive power for hepatotoxicity of Chinese HMs.

A permeation cup method for screening packaging materials for fragrance preservation in Chinese medicine

2016 ◽  
Vol 8 (40) ◽  
pp. 7387-7395 ◽  
Author(s):  
Xianghui Li ◽  
Ling Li ◽  
Yunlong Song ◽  
Huiliang Li ◽  
Zhenyu Zhu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicines ◽  
Barrier Properties ◽  
Volatile Components ◽  
Packaging Materials ◽  
Chinese Herbal Medicines ◽  
Plastic Packaging ◽  
Chinese Herbal

Barrier properties of common plastic packaging materials were efficiently evaluated using a permeation cup method with GC-MS, in order to prevent loss of volatile components in typical Chinese herbal medicines.

Treatment of Diabetes Using Traditional Chinese Medicine: Past, Present and Future

2012 ◽  
Vol 40 (05) ◽  
pp. 877-886 ◽  
Author(s):  
Xiao-Lin Tong ◽  
Liu Dong ◽  
Liang Chen ◽  
Zhong Zhen
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Herbal Medicines ◽  
Basic Research ◽  
Holistic Approach ◽  
Medical Problem ◽  
The Past ◽  
Chinese Herbal ◽  
Treatment Of Diabetes ◽  
Tcm Theory

Diabetes is a major medical problem that imperils public health. Over two thousand years ago, Traditional Chinese Medicine (TCM) called diabetes-related symptoms "Xiaoke" disease. In ancient China, TCM and Chinese herbal medicines were used widely in treating Xiaoke and abundant experience has been accumulated. This article discusses the TCM theory on diabetes and its achievements in the prevention and treatment of diabetes in the past. Using Chinese herbal medicine, recent progress in diabetes therapeutics, including data from clinical trials, are presented. Mechanistic studies from basic research are discussed. Yin-yang balance and a holistic approach of TCM may complement diabetes treatment in Western medicine. With continuous efforts, TCM could play a more important role in fighting this disease.

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