Application of an efficient strategy for discovery and purification of bioactive compounds from Chinese herbal medicines, a case study on the Puerariae thomsonii Flos

2013 ◽  
Vol 75 ◽  
pp. 25-32 ◽  
Author(s):  
Qi Wang ◽  
Xiao-Lan Cheng ◽  
Huan Li ◽  
Xiao-Ying Qin ◽  
Chi-Yu Ge ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Efficient Strategy ◽  
Chinese Herbal

scholarly journals Stability of Alkaloids during Drying Process and Their Effect on Anticoagulating Activity of Uncariae Ramulus Cum Uncis

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Lu Zou ◽  
Fengyu Lu ◽  
Bing Lin ◽  
Ying Zhou ◽  
Tingting Liu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Constant Temperature ◽  
Herbal Medicines ◽  
Procoagulant Activity ◽  
Drying Process ◽  
Coagulation Time ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

The drying process of Uncariae Ramulus Cum Uncis (URCU), a kind of traditional Chinese medicine, was studied in a scale dryer in laboratory at 65°C. It was observed that the alkaloids content of URCU firstly showed a tendency of increasing and then decreasing after reaching the peak at the 570th minute in the process of constant temperature drying. Moreover, the coagulation time of rabbit determined by test tubes has been adopted to study the effect imposed by the content of alkaloids on the anticoagulating activity of URCU. In addition, the software of Minitab was also utilized to fit the correlation between the content of alkaloids and the anticoagulating activity of URCU. The results obtained demonstrated that anticoagulant activities were available in both rhynchophylline and isorhynchophylline, among which the latter was the stronger one, while procoagulant activity was shown in corynoxeine. The case study can provide a useful reference for the research on drying other Chinese herbal medicines (CHMs) and further study on URCU.

The Role of Traditional Chinese Herbal Medicines and Bioactive Ingredients on Ion Channels: A Brief Review and Prospect

2019 ◽  
Vol 18 (4) ◽  
pp. 257-265 ◽  
Author(s):  
Yian Huang ◽  
Shumei Ma ◽  
Yan Wang ◽  
Renjie Yan ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Ion Channels ◽  
Bioactive Compounds ◽  
Cannabis Sativa ◽  
Salvia Miltiorrhiza ◽  
Curcuma Longa ◽  
Herbal Medicines ◽  
Scientific Basis ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Regulatory Effects

Traditional Chinese Medicines (TCMs), particularly the Chinese herbal medicines, are valuable sources of medicines and have been used for centuries. The term “TCMs” both represents to the single drug agent like Salvia miltiorrhiza, Ligusticum chuanxiong and Angelica sinensis, and those herbal formulas like Jingshu Keli, Wenxin Keli and Danzhen powder. In recent years, the researches of TCMs developed rapidly to understand the scientific basis of these herbs. In this review, we collect the studies of TCM and their containing bioactive compounds, and attempt to provide an overview for their regulatory effects on different ion channels including Ca2+, K+, Na+, Cl- channels and TRP, P2X receptors. The following conditions are used to limit the range of our review. (i) Only the herbal materials are included in this review and the animal- and mineral-original TCMs are excluded. (ii) The major discussions in this review focus on single TCM agent and the herbal formulas are only discussed for a little. (iii) Those most famous herbal medicines like Capsicum annuum (pepper), Curcuma longa (ginger) and Cannabis sativa (marijuana) are excluded. (iv) Only those TCM herbs with more than 5 research papers confirming their effects on ion channels are discussed in this review. Our review discusses recently available scientific evidences for TCMs and related bioactive compounds that have been reported with the modulatory effects on different ion channels, and thus provides a new ethnopharmacological approach to understand the usage of TCMs.

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