scholarly journals Hypereosinophilic Syndrome, Cardiomyopathies, and Sudden Cardiac Death in Superinvasive Opisthorchiasis

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Vitaly G. Bychkov ◽  
Vladimir M. Zolotukhin ◽  
Elena D. Khadieva ◽  
Svetlana V. Kulikova ◽  
Ivan M. Petrov ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Heart Muscle ◽  
Cardiac Death ◽  
Myocardial Metabolism ◽  
Hypereosinophilic Syndrome ◽  
Cardiovascular Pathology ◽  
Healthcare Facilities ◽  
Icd 10

Cardiovascular pathology in patients with superinvasive opisthorchiasis is characterized by severe changes in haemodynamics and myocardial metabolism, impaired automatism, excitability, and conduction of the heart muscle. An analysis of 578 cases (medical and outpatient records and reports of pathoanatomical and forensic autopsies) recorded in healthcare facilities treating opisthorchiasis patients with a hyperendemic focus was carried out. We identified a set of cardiac changes in patients with hypereosinophilic syndrome associated with superinvasive opisthorchiasis infection, classified the pathological processes in accordance with ICD-10, and described their pathogenesis.

scholarly journals Cardiovascular Pathology in Patients With COVID-19

Kardiologiia ◽  
2020 ◽  
Vol 60 (8) ◽  
pp. 23-26
Author(s):  
E. K. Serezhina ◽  
A. G. Obrezan
Keyword(s):  
Heart Failure ◽  
Chest Pain ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Myocardial Injury ◽  
Heart Rhythm ◽  
Hospitalized Patients ◽  
Cardiovascular Pathology ◽  
Heart Rhythm Disorders ◽  
Coronavirus Infection

In the recent months of the COVID-19 pandemics, the cardiological society has faced a new challenge, myocardial injury by the coronavirus infection. According to statistics, 20-40% of hospitalized patients have chest pain, heart rhythm disorders, heart failure, and sudden cardiac death syndrome. This review focuses on recent studies and clinical cases related with this issue.

Neutrons and Sudden Cardiac Death (SCD)-Codes 121-125 ICD 10

2006 ◽  
Vol 17 (1) ◽  
Author(s):  
Ε. Stoupel ◽  
S. Domarkiene ◽  
R. Radishauskas ◽  
E. Abramson ◽  
P. Israelevich ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Icd 10

A new designer drug: Methylone related death

2012 ◽  
Vol 153 (7) ◽  
pp. 271-276 ◽  
Author(s):  
Katalin Kovács ◽  
Anita Réka Tóth ◽  
Éva Margit Kereszty
Keyword(s):  
Sudden Cardiac Death ◽  
Bronchial Asthma ◽  
Heart Muscle ◽  
Cardiac Death ◽  
Illicit Drugs ◽  
Fatal Case ◽  
Previous History ◽  
Designer Drugs ◽  
Gas Chromatography Mass Spectrometry ◽  
Designer Drug

This report presents a fatal case related to the consumption of methylone, a relatively new cathinone type designer drug. A 16-year-old boy suddenly lost his consciousness in a party. Resuscitation had been continued for about 1.5 hours at the intensive care unit, but it was unsuccessful. His previous history included cardiac malformation detected at infancy and bronchial asthma had been diagnosed one year before his death. Signs of sudden cardiac death were observed during autopsy. Methylone intake was proved in blood and liver extract using gas chromatography/mass spectrometry; its concentration was 272 ng/ml in the blood, and 387 ng/g in the liver. Pathohistology revealed microvascular steatosis in the liver, which raised the possibility of chronic use of toxic substances. In addition, striated heart muscle damage was observed, which could be due to the use of an amphetamine-like substance. The authors presume that steatosis of the heart muscle, congenital heart disease and bronchial asthma could be predisposing factors for sudden cardiac death that occurred in the presence of relatively low levels of methylone. Access to various designer drugs is easy, fast and broad. Consequently, the potential abuse or overdose should be taken into consideration in the emergency practice. The use of “non-illicit” drugs does not require formal intervention by the authorities, but the medical service must alarm the stakeholders. Orv. Hetil., 2012, 153, 271–276.

scholarly journals Mechanisms of Damage to the Cardiovascular System in COVID-19

2021 ◽  
Vol 76 (3) ◽  
pp. 287-297
Author(s):  
Alexandr Y. Fisun ◽  
Yuriy V. Lobzin ◽  
Dmitry V. Cherkashin ◽  
Vadim V. Tyrenko ◽  
Konstantin N. Tkachenko ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiovascular System ◽  
Heart Muscle ◽  
Cardiac Death ◽  
Myocardial Damage ◽  
Angiotensin Converting Enzyme 2 ◽  
Coronary Syndrome ◽  
Life Threatening ◽  
Potential Benefits ◽  
Myocardial Involvement

The review article is devoted to the analysis of the literature on the various mechanisms of damage to the cardiovascular system in COVID-19. The article briefly outlines the epidemiology and urgency of the COVID-19 problem, describes the features of the clinical picture of heart muscle damage in COVID-19. The pathophysiology, morphology and pathogenetic mechanisms of myocardial involvement in cases of SARS-CoV-2 lesion are considered in detail. The authors present a diagram of various mechanisms of myocardial damage in COVID-19, which includes mediated damage to the heart muscle through angiotensin-converting enzyme 2, myocardial damage caused by hypoxemia, microvascular heart damage, and systemic inflammatory response syndrome. A detailed scheme of cardiomyocyte infection with the involvement of cytokines, which ultimately leads to myocardial remodeling and dilated cardiomyopathy, is presented. The pathophysiological foundations of the development of sudden cardiac death in COVID-19, which include the mechanisms of life-threatening arrhythmias, acute coronary syndrome, and heart failure, are considered. The authors analyzed scientific studies of the toxic effects of COVID-19 drug treatment on the heart muscle, in particular, antiviral, antibacterial, antimalarial agents. Their potential benefits and harms, as well as the likelihood of developing cardiovascular events, in particular sudden cardiac death, were assessed.

scholarly journals 2017-2019 Sudden cardiac death registry of the Zabaykalsky Krai population (ZODIAC)

2020 ◽  
Vol 25 (11) ◽  
pp. 3997
Author(s):  
D. N. Zaitsev ◽  
P. V. Vasilenko ◽  
A. V. Govorin ◽  
E. A. Vasilenko ◽  
N. V. Mukha ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Ethyl Alcohol ◽  
Cardiac Death ◽  
Age Groups ◽  
Statistical Processing ◽  
Decompensated Heart Failure ◽  
Blood Alcohol ◽  
Icd 10 ◽  
Coronary Syndromes ◽  
The Mean

Aim. Based on the autopsy data, to analyze mortality patterns of the Zabaykalsky Krai population over a three-year period in the group of out-of-hospital sudden cardiac death (SCD).Material and methods. The protocols of deceased persons without evidence for violent death were analyzed with distribution into groups depending on age, sex and cause of death. Descriptive statistics were used for statistical processing.Results. The leading positions (58% of cases) in mortality patterns are occupied by various types of coronary artery disease (CAD). Chronic coronary syndromes were detected in 21%, cardiomyopathy — in 11%, decompensated heart failure — in 7%, myocarditis — in 1% of cases. Acute types of CAD were found in 68,4% in men and 31,6% in women. Among men, the number of such cases increases from 31 to 70 years of age and decreases over 70 years old. Among women, there is an increase in the SCD prevalence in the group over 70 years old.Chronic coronary syndromes were found in 46,4% in men and 53,6% in women. In both groups the number of cases increases with age. The maximum sex differences are observed in the group over 70 years old. The mean age for men is 72,2±8,8 years, for women — 77,2±10,4 years. Blood alcohol was detected in 10,2% of cases. The mean age of the deceased in all age groups of persons with identified blood alcohol was 66,2±12 years.In 1,89% of cases, I46 code (ICD-10) was established. The largest number of deaths among persons of both sexes was registered in the group of 31-40 years old, accounting for 36,8% among men and 13,2% among women. The mean age of the deceased was 35,8±8,4 years. In 28,6% of cases, ethyl alcohol was found in the biological media of the deceased in this group.Conclusion. Acute and chronic types of CAD make a significant contribution to out-of-hospital mortality. The number of SCD in men is higher than in women and is directly proportional to the age increase, reaching a maximum in the group over 70 years old. Ethyl alcohol, an important trigger of SCD, was detected in 10,8% of SCD cases in 2017, and in 15% in 2018 and 2019.

scholarly journals Changes in Myocardial Metabolism Preceding Sudden Cardiac Death

2020 ◽  
Vol 11 ◽  
Author(s):  
J. Snyder ◽  
R. Zhai ◽  
A. I. Lackey ◽  
P. Y. Sato
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Myocardial Metabolism

scholarly journals Autopsy examination in sudden cardiac death: a current perspective on behalf of the Association for European Cardiovascular Pathology

2020 ◽  
Author(s):  
Jytte Banner ◽  
Cristina Basso ◽  
Zoe Tolkien ◽  
Ivana Kholova ◽  
Katarzyna Michaud ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Disease ◽  
Cardiac Death ◽  
General Tendency ◽  
Genetic Studies ◽  
Cardiovascular Pathology ◽  
Current Perspective ◽  
Autopsy Examination ◽  
Standard Of Practice ◽  
Inherited Cardiac Disease

Abstract In sudden cardiac death, an autopsy is an essential step in establishing a diagnosis of inherited cardiac disease and identifying families that require cardiac screening. To evaluate aspects of post-mortem practice in Europe, a questionnaire was designed and circulated to both clinical and forensic pathologists. There was a 48% response rate and information was obtained from 17 countries. The results showed a wide variety in the management of sudden cardiac death, with a general tendency towards a lack of thorough investigation. In up to 40% of cases, autopsies were not performed in subjects less than 50 years who may have died from cardiac disease. Reasons for this were lack of finance and lack of interest from police, legal authorities, and doctors. Only 50% of pathologists seem to follow a standard protocol for autopsy examination, apparently due to lack of expertise and/or training. When autopsies were performed, histology and toxicology were almost always taken, genetic studies were generally available and retention of the heart for specialist study was usually permitted. Our results suggest that although the standard of practice is appropriate in many centres, many more cases should have autopsies, especially in sudden deaths in subjects less than 50 years.

scholarly journals Methylation of f2rl3, cdkn2a genes and sudden cardiac death

2022 ◽  
Vol 17 (4) ◽  
pp. 6-10
Author(s):  
A. A. Ivanova ◽  
A. A. Gurazheva ◽  
S. V. Maksimova ◽  
S. K. Malyutina ◽  
V. P. Novoselov ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Methylation Status ◽  
Control Group ◽  
Coronary Insufficiency ◽  
Cardiovascular Pathology ◽  
Cdkn2a Gene ◽  
Acute Coronary Insufficiency ◽  
European Society Of Cardiology ◽  
Control Study

The aim of the study was to evaluate the association of methylation of the F2RL3, CDKN2A gene with sudden cardiac death (SCD). Material and methods. Case-control study design. The SCD group included 150 deceased men (mean age 46.7 ± 9.2 years) with the main pathological diagnoses of acute circulatory failure, acute coronary insufficiency, which meets the SCD criteria of the European Society of Cardiology. The control group included 150 men who died suddenly, but not due to cardiovascular pathology (mean age 42.6 ± 1.2 years). DNA was isolated by phenol-chloroform extraction from myocardial tissue in both groups. The methylation status of the F2RL3 gene (19: 16890405-16890606, GRCh38.p13) and the CDKN2A gene (9: 21974726-21974877, GRCh38.p13) was assessed by methyl-specific polymerase chain reaction. Results. In the SCD group, 17.3 % (26/150) had the F2RL3 gene completely methylated (MM); in 6.0 % (9/150) it is completely unmethylated (UU); 76.7 % (115/150) had both methylated and unmethylated F2RL3 (MU) gene. In the control group, 16 % (24/150) had the F2RL3 gene completely methylated (MM); in 5.3 % (8/150), it is completely unmethylated (UU); 78.7 % (118/150) had both methylated and unmethylated F2RL3 (MU) gene. When comparing the groups, there were no statistically significant differences in the methylation status of the F2RL3 gene between the groups (p > 0.05). In all subjects in the SCD group and the control group, the CDKN2A gene is completely unmethylated. Conclusions. Methylation of genes F2RL3, CDKN2A is not associated with sudden cardiac death.

A study of the morphological features of the heart muscle in sudden cardiac death

2020 ◽  
Vol 15 (3) ◽  
pp. 31-35
Author(s):  
S.N. Kolyubaeva ◽  
V.A. Kachnov ◽  
V.V. Tyrenko ◽  
V.S. Chirsky ◽  
L.S. Onishchenko ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Heart Muscle ◽  
Cardiac Death ◽  
Morphological Features
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