scholarly journals Insights on the Multifunctional Activities of Magnolol

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Jianhong Zhang ◽  
Zhixi Chen ◽  
Xianhua Huang ◽  
Weimei Shi ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Natural Compound ◽  
Therapeutic Agent ◽  
Water Solubility ◽  
Biological Activities ◽  
Biological Functions ◽  
Metabolism Regulation ◽  
Magnolia Officinalis ◽  
Promising Therapeutic Agent

Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated fromMagnolia officinalis, has been extensively documented and shows a range of biological activities. Many signaling pathways include, but are not limited to, NF-κB/MAPK, Nrf2/HO-1, and PI3K/Akt pathways, which are implicated in the biological functions mediated by magnolol. Thus, magnolol is considered as a promising therapeutic agent for clinic research. However, the low water solubility, the low bioavailability, and the rapid metabolism of magnolol dramatically limit its clinical application. In this review, we will comprehensively discuss the last five-year progress of the biological activities of magnolol, including anti-inflammatory, antimicroorganism, antioxidative, anticancer, neuroprotective, cardiovascular protection, metabolism regulation, and ion-mediating activity.

Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis

2020 ◽  
Vol 21 (6) ◽  
pp. 559-572 ◽  
Author(s):  
Yuan Yuan ◽  
Xiaocui Zhou ◽  
Yuanyuan Wang ◽  
Yan Wang ◽  
Xiangyan Teng ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cardiac Hypertrophy ◽  
Therapeutic Potential ◽  
Current Data ◽  
Polyphenolic Compounds ◽  
Comprehensive Review ◽  
Magnolia Officinalis

Honokiol and its isomer magnolol are poly-phenolic compounds isolated from the Magnolia officinalis that exert cardiovascular modulating effects via a variety of mechanisms. They are used as blood-quickening and stasis-dispelling agents in Traditional Chinese Medicine and confirmed to have therapeutic potential in atherosclerosis, thrombosis, hypertension, and cardiac hypertrophy. This comprehensive review summarizes the current data regarding the cardioprotective mechanisms of those compounds and identifies areas for further research.

scholarly journals A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Di Chen ◽  
Fangbo Zhang ◽  
Shihuan Tang ◽  
Yan Chen ◽  
Peng Lu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Airway Inflammation ◽  
Systematic Study ◽  
Steroid Metabolism ◽  
Cough Variant Asthma ◽  
Functional Annotations ◽  
Metabolism Regulation ◽  
Significant Efficacy ◽  
Clinical Cases

Traditional Chinese medicine (TCM) has shown significant efficacy in the treatment of cough variant asthma (CVA), a special type of asthma. However, there is shortage of explanations for relevant mechanism of treatment. As Zhengs differentiation is a critical concept in TCM, it is necessary to explain the mechanism of treatment of Zhengs. Based on TCM clinical cases, this study illustrated the mechanism of the treatment of three remarkably relevant Zhengs for CVA: “FengXieFanFei,” “FeiQiShiXuan”, and “QiDaoLuanJi.” To achieve this goal, five steps were carried out: (1) determining feature Zhengs and corresponding key herbs of CVA by analyses of clinical cases; (2) finding out potential targets of the key herbs and clustering them based on their functional annotations; (3) constructing an ingredient-herb network and an ingredient network; (4) identifying modules of the ingredient network; (5) illustrating the mechanism of the treatment by further mining the latent biological implications within each module. The systematic study reveals that the treatment of “FengXieFanFei,” “FeiQiShiXuan,” and “QiDaoLuanJi” has effects on the regulation of multiple bioprocesses by herbs containing different ingredients with functions of steroid metabolism regulation, airway inflammation, and ion conduction and transportation. This network-based systematic study will be a good way to boost the scientific understanding of mechanism of the treatment of Zhengs.

scholarly journals Leonurine, a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Di Yang ◽  
Wanwan Jia ◽  
Yi Zhun Zhu
Keyword(s):  
Natural Products ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Future Perspectives ◽  
Effective Agent ◽  
Recent Advances

Herba Leonuri, also named Chinese Motherwort, has been extensively investigated as an effective agent on the uterus system. Our group has been studying the natural products of Herba Leonuri for several years, and during this period, many biological activities of the drug were recognized. Leonurine (4-guanidino- N-butyl-syringate) is an alkaloid present in Herba Leonuri. Recently, growing evidence has highlighted the therapeutic potential of leonurine in multiple diseases, especially cardiovascular. In this review, we discuss the biological activities of leonurine, as well as recent advances involving this alkaloid.

scholarly journals Biological Activities of Gedunin—A Limonoid from the Meliaceae Family

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 493 ◽  
Author(s):  
Teresa M. Braga ◽  
Lídia Rocha ◽  
Tsz Yan Chung ◽  
Rita F. Oliveira ◽  
Cláudia Pinho ◽  
...  
Keyword(s):  
Heat Shock ◽  
Literature Review ◽  
Heat Shock Protein ◽  
Natural Compound ◽  
Therapeutic Agent ◽  
Biological Activities ◽  
Neuroprotective Effects ◽  
Future Directions ◽  
Important Landmark ◽  
Critical Literature

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.

scholarly journals Research Progress on the Antitumor Effect of Polysaccharides from Fungus Used in Traditional Chinese Medicine

2021 ◽  
Vol 5 (5) ◽  
pp. 7-10
Author(s):  
Ru Xiang ◽  
Bing Xu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Antitumor Effect ◽  
Biological Activities ◽  
Research Progress ◽  
Cancer Breast ◽  
Wide Range ◽  
Low Toxicity ◽  
Fungal Polysaccharides ◽  
Cancer Côlon

Cancer is a serious threat to human health. Fungal polysaccharide is a polar biological macromolecule with low toxicity. It has a wide range of biological activities, including immune regulation, antitumor activity, and antiviral activity. In recent years, the research results have shown that polysaccharides from fungus in traditional Chinese medicine have excellent antitumor effect in liver cancer, gastric cancer, breast cancer, colon cancer, esophageal cancer, and lung cancer. Therefore, the research and development of fungal polysaccharides are of great significance for the development of antitumor drugs in the future.

scholarly journals Research progress of icariin, an extract of traditional Chinese medicine, in the treatment of asthma

2022 ◽  
Vol 50 (1) ◽  
pp. 9-16
Author(s):  
Jia-ying Yuan ◽  
Zhi-ying Tong ◽  
Yu-chao Dong ◽  
Jia-yi Zhao ◽  
Yan Shang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Biological Activities ◽  
Airway Disease ◽  
Research Direction ◽  
Research Progress ◽  
Therapeutic Drug ◽  
First Choice ◽  
Wide Range ◽  
New Research

Bronchial asthma is a common chronic airway disease, and long-term management of asthma is the focus and difficulty of clinical treatment. Glucocorticoids are often used as the first choice for the treatment of asthma. However, the occurrence of hormone dependence, hormone resistance, local and systemic adverse reactions caused by hormone application also brings problems for the treatment of asthma. Finding safe and effective new therapeutic drugs is an important research direction at present. Icariin is the effective ingredient of traditional Chinese medicine Epimedium. It has various biological activities such as anti-inflammatory, anti-oxidative stress, and immune regulation. It has high safety and has a wide range of clinical applications. Icariin has the characteristics of multi-target intervention in the treatment of asthma. This article reviews recent studies in order to provide new research directions for further therapeutic drug development.

scholarly journals Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine

RSC Advances ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 2458-2463 ◽  
Author(s):  
Jing Jing ◽  
Karnaker R. Tupally ◽  
Ganesh R. Kokil ◽  
Zhi Qu ◽  
Sibao Chen ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Delivery System ◽  
Therapeutic Agent ◽  
Hybrid Peptide ◽  
Carrier System ◽  
Cane Toad ◽  
Amphiphilic Peptide ◽  
Toad Poison ◽  
Peptide Dendrimer

A novel amphiphilic peptide dendrimer-based delivery system was developed for a cane toad poison-derived steroid. The methodology to incorporate lipid into asymmetric dendrimers generated self-assembled micelles.

Bioactive Compounds of Polygonatum Sibiricum - Therapeutic Effect and Biological Activity

2021 ◽  
Vol 21 ◽  
Author(s):  
Xin Zhao ◽  
Suryaji Patil ◽  
Qian Airong ◽  
Caihong Zhao
Keyword(s):  
Biological Activity ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Effect ◽  
Bioactive Compounds ◽  
Antimalarial Drug ◽  
Biological Activities ◽  
Modern Medicine ◽  
Triterpenoid Saponins ◽  
Immense Potential

Abstract: Plants serves as an important source of medicinal compounds and their use in various diseases dates back to hundreds of years. One such plant-based compound and the discovery of the antimalarial drug, artemisinin, have significantly brought phytomedicines into the spotlight and have enhanced the understanding and consequently, the application of formulations derived from plants. Traditional Chinese Medicine (TCM), which is based primarily on plants, holds immense potential and is an unexplored source for modern medicine. Many herbs including Polygonatum sibiricum (PS) are used in Chinese medicine as a treatment for various diseases. Polygonatum sibiricum (PS) belongs to the Liliaceae family and is used not only as a medicinal but also dietary supplement. PS has a highly diverse composition of bioactive compounds such as flavones, homoisoflavanone, alkaloids, lignins, steroid saponins, triterpenoid saponins, polysaccharides, etc. Because of such diverse composition, PS has been used as an anti-aging, anti-inflammatory, anti-osteoporotic, as well as an immunity booster, sleep enhancer, etc. Therefore, in his article, we review the therapeutic effect of bioactive compounds such as polysaccharides, saponins, and PS extract in various diseases and their biological activities in fatigue, immunity, sleep, anti-aging, etc.

scholarly journals Chemical Constituents of Yarsagumba (Ophiocordyceps sinensis (Berk.) Sung et al.), a Valued Traditional Himalayan Medicine

2013 ◽  
Vol 13 (1) ◽  
pp. 43-58 ◽  
Author(s):  
Sabina Shrestha ◽  
Bhushan Shrestha ◽  
Ji-Hae Park ◽  
Dae-Young Lee ◽  
Jin-Gyeong Cho ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Health Conditions ◽  
Nitrogenous Compounds ◽  
Entomogenous Fungus ◽  
Ophiocordyceps Sinensis ◽  
Wide Range

Ophiocordyceps sinensis (Berk.) Sung et al. is popularly known as Yarsagumba (winter worm summer grass) in Nepal. It is a well-known entomogenous fungus distributed in alpine nival zone of trans-Himalayas and Tibetan Plateau. Its occurrence in extreme biological niche and cohabitation with insect [Thitarodes (Hepialus)] larvae has led to unique assemblage of metabolites including proteins and nitrogenous compounds, polysaccharides, sterols, nucleosides, fatty acids and their derivatives, vitamins and inorganics. In traditional Chinese medicine, it is one of the most trusted main ingredients for several preparations of remedy from wide range of human health conditions. Several biological activities from O. sinensis have been reported that include anti-inflammatory, antioxidant, antitumor, anti-metastatic, immunomodulatory, antimicrobial, insecticidal, hypolipidaemic, hypoglycemic, anti-ageing, lipolytic, neuroprotective, renoprotective effects, etc. The chemical constituents and their pharmacological uses are reviewed here highlighting the potentiality of this highly esteemed traditional Himalayan medicine. Nepal Journal of Science and Technology Vol. 13, No. 1 (2012) 43-58 DOI: http://dx.doi.org/10.3126/njst.v13i1.7398

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