scholarly journals Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine

RSC Advances ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 2458-2463 ◽  
Author(s):  
Jing Jing ◽  
Karnaker R. Tupally ◽  
Ganesh R. Kokil ◽  
Zhi Qu ◽  
Sibao Chen ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Delivery System ◽  
Therapeutic Agent ◽  
Hybrid Peptide ◽  
Carrier System ◽  
Cane Toad ◽  
Amphiphilic Peptide ◽  
Toad Poison ◽  
Peptide Dendrimer

A novel amphiphilic peptide dendrimer-based delivery system was developed for a cane toad poison-derived steroid. The methodology to incorporate lipid into asymmetric dendrimers generated self-assembled micelles.

scholarly journals Application of traditional Chinese medicine preparation in targeting drug delivery system

Drug Delivery ◽  
2014 ◽  
Vol 22 (3) ◽  
pp. 258-265 ◽  
Author(s):  
Wei Xu ◽  
Feng J. Xing ◽  
Kai Dong ◽  
Cuiyu You ◽  
Yan Yan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Traditional Chinese Medicine Preparation

The Contribution of Traditional Chinese Medicine Compound in Nasal Drug Delivery System

2021 ◽  
pp. 95-116
Author(s):  
Xuechun Liu ◽  
Haiyan Hu ◽  
Ziqi Chen ◽  
Zekang Zhang ◽  
Changhai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nasal Drug Delivery

Recent Advances in Drug Delivery System for Bioactive Glycosides from Traditional Chinese Medicine

2018 ◽  
Vol 46 (08) ◽  
pp. 1791-1824 ◽  
Author(s):  
Lei Li ◽  
Yi Feng ◽  
Yanlong Hong ◽  
Xiao Lin ◽  
Lan Shen
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Design Strategies ◽  
Active Ingredients ◽  
Recent Advances ◽  
Delivery Vehicles

Traditional Chinese Medicine (TCM) has been used in China for thousands of years for the prevention and treatment of various diseases. The materials that exert a therapeutic effect are called the active ingredients. The bioactive glycosides are important active ingredients from TCM that can make significant contributions to treating diseases. Because of the possibilities of various clinical applications, the properties and administration of these bioactive glycosides deserve further investigation. Their promising treatment effects, however, are hindered by their poor solubility, poor stability and rapid elimination. Therefore, it is necessary that we improve the therapeutic efficacy of bioactive glycosides by overcoming these problems. Meanwhile, some practical design strategies and novel drug delivery vehicles based on drug delivery systems provide favorable support in clinical practice for these active ingredients. This review summarizes diverse pharmacological activities of bioactive glycosides and focuses on recent advances in delivery system for these active constitutes; in particular, some glycol glycosides can effectively cure intractable diseases through targeted drug delivery. This review elucidates some design strategies for drug delivery system that are mainly based on two methods (avoiding physical barriers by changing dosage forms and enhancing the ability to bind to receptors or proteins after administration) and indicate the current challenges during the combination of delivery vehicles and these glycosides in hopes of promoting the process of receiving ideal therapeutic efficacy of them in future studies.

Arsenite-loaded albumin nanoparticles for targeted synergistic chemo-photothermal therapy of HCC

2021 ◽  
Author(s):  
Ke Zhang ◽  
Dan Li ◽  
Bin Zhou ◽  
Jiani Liu ◽  
Xiangjie Luo ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Arsenic Trioxide ◽  
Acute Promyelocytic Leukemia ◽  
Active Ingredient ◽  
Photothermal Therapy ◽  
Therapeutic Agent ◽  
Promyelocytic Leukemia ◽  
Albumin Nanoparticles ◽  
The U.S

Arsenic trioxide (ATO, As2O3), an active ingredient of traditional Chinese medicine, has been approved by the U.S. Food and Drug Administration as an effective therapeutic agent for acute promyelocytic leukemia (APL).

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